Tracking cancer‐related fatigue during chemotherapy: Insights from a comparative cohort study of early breast cancer patients

Cancer‐related fatigue (CRF) is a multifactorial symptom commonly experienced by breast cancer patients treated with chemotherapy (CT) that impairs quality of life and may influence cancer recurrence by reducing treatment compliance. This cohort study examined the kinetics of CRF throughout CT in br...

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Vydané v:	International journal of cancer Ročník 157; číslo 8; s. 1625 - 1636
Hlavní autori:	Mallard, Joris, Hucteau, Elyse, Schott, Roland, Pivot, Xavier, Pagano, Allan F., Hureau, Thomas J.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Hoboken, USA John Wiley & Sons, Inc 15.10.2025 Wiley Subscription Services, Inc Wiley
Predmet:	Adult Aged Breast cancer Breast Neoplasms - complications Breast Neoplasms - drug therapy Breast Neoplasms - physiopathology Cancer Chemotherapy Cohort analysis Cohort Studies Endocrinology and metabolism Exercise Exercise - physiology exercise capacity Exercise Tolerance Fatigue Fatigue - chemically induced Fatigue - etiology Fatigue - physiopathology Female Human health and pathology Humans Knee Life Sciences Middle Aged Muscle Fatigue - drug effects muscle force muscle mass neuromuscular fatigue Physical activity Physical fitness Physical training Quality of Life RESEARCH ARTICLE six‐minute walk test Walking muscle mass exercise capacity muscle force six‐minute walk test neuromuscular fatigue Global Physical Activity Questionnaire ICANS 6-minute walking test CRF cancer-related fatigue Global Physical Activity Questionnaire chemotherapy six-minute walk test 6-MWT Receiver Operating Characteristic Functional Assessment of Chronic Illness Therapy-Fatigue ROC Institut de Cancérologie Strasbourg Europe MET chemotherapy FACIT-F 6-minute walking test Functional Assessment of Chronic Illness Therapy-Fatigue GPAQ cancer-related fatigue CT metabolic equivalents CT CRF GPAQ MET FACIT-F metabolic equivalents ROC
ISSN:	0020-7136, 1097-0215, 1097-0215
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Shrnutí:	Cancer‐related fatigue (CRF) is a multifactorial symptom commonly experienced by breast cancer patients treated with chemotherapy (CT) that impairs quality of life and may influence cancer recurrence by reducing treatment compliance. This cohort study examined the kinetics of CRF throughout CT in breast cancer patients and determined its relationship with exercise‐related variables. One hundred breast cancer patients were included. Three time points were investigated: pre‐CT, 8 weeks, and post‐CT. Patients were categorized as fatigued or non‐fatigued according to their FACIT‐F score. Exercise capacity (assessed using the 6‐minute walking test), muscle mass and force, neuromuscular fatigue, and physical activity level were measured. Among the seven patterns of CRF trajectories identified, three represented 78% of the fatigued patients. Fatigued patients exhibited reduced exercise capacity compared to non‐fatigued patients during CT (p = 0.001). This was associated with greater knee extensor (p < 0.001) and handgrip (p = 0.009) neuromuscular fatigue and lower physical activity level (p < 0.001) in fatigued patients. The model combining knee extensors neuromuscular fatigue (p = 0.007) and force (p = 0.081), 6‐minute walking test distance (p < 0.001) and physical activity level (p = 0.029) explained 39% of the variance in the FACIT‐F score evolution from pre‐ to post‐CT. The dissociation between fatigued versus non‐fatigued patients highlighted that CRF was associated with altered exercise capacity and neuromuscular fatigue. Exercise‐related variables seem to play an important role in CRF evolution during CT, suggesting that exercise training should be initiated at the start of CT. What's New? Cancer‐related fatigue is a multifactorial symptom commonly experienced by breast cancer patients treated with chemotherapy. Here, the authors investigated the temporal associations between cancer‐related fatigue and exercise capacity to better tailor exercise interventions during chemotherapy. The cohort study identified seven cancer‐related fatigue trajectories, with three of them experienced by 78% of patients. Cancer‐related fatigue was associated with reduced exercise capacity, neuromuscular fatigue, and lower physical activity level. One model based on four exercise‐related parameters explained 39% of the variance in cancer‐related fatigue evolution, emphasizing the need for early exercise interventions prioritizing both exercise capacity and neuromuscular force.
Bibliografia:	Joris Mallard and Elyse Hucteau have contributed equally to this study. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0020-7136 1097-0215 1097-0215
DOI:	10.1002/ijc.35508