Decreased Subcutaneous Adipose Tissue Correlates With Higher Portal Hypertension and Poor Survival in Patients With Cirrhosis: A Retrospective Binary-Center Study

INTRODUCTION:The aim of this study was to investigate the impact of hepatic venous portal gradient (HVPG) on body composition (BC) values and the prognostic value of BC value in cirrhotic patients.METHODS:A total of 173 cirrhotic patients with HVPG and computed tomography scan were screened retrospe...

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Vydáno v:Clinical and translational gastroenterology Ročník 16; číslo 5; s. e00836
Hlavní autoři: Yang, Siwei, Ren, Xiuwan, Guo, Xiaoqing, Yu, Jianan, Niu, Lizhen, Niu, Yao, Zhang, Linpeng, Jin, Long
Médium: Journal Article
Jazyk:angličtina
Vydáno: Philadelphia, PA Wolters Kluwer 01.05.2025
Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
Témata:
Adult
Aged
Ascites
Biopsy
Body Composition
Body fat
Catheters
Chronic illnesses
Correlation analysis
Endoscopy
Female
Humans
Hypertension
Hypertension, Portal - diagnosis
Hypertension, Portal - epidemiology
Hypertension, Portal - etiology
Intra-Abdominal Fat - diagnostic imaging
Liver
Liver cirrhosis
Liver Cirrhosis - complications
Liver Cirrhosis - mortality
Liver Cirrhosis - physiopathology
Liver diseases
Male
Medical imaging
Middle Aged
Muscle, Skeletal - diagnostic imaging
Musculoskeletal system
Normal distribution
Patients
Prognosis
Retrospective Studies
Risk Factors
Sarcopenia
Subcutaneous Fat - diagnostic imaging
Subcutaneous Fat - pathology
Survival Rate
Tomography, X-Ray Computed
Veins & arteries
body composition
portal hypertension
correlation
prognosis
liver cirrhosis
ISSN:2155-384X, 2155-384X
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Shrnutí:INTRODUCTION:The aim of this study was to investigate the impact of hepatic venous portal gradient (HVPG) on body composition (BC) values and the prognostic value of BC value in cirrhotic patients.METHODS:A total of 173 cirrhotic patients with HVPG and computed tomography scan were screened retrospectively from a binary-center database. Seven BC values, including skeletal muscle index, subcutaneous adipose tissue index (SATI), deep SATI (dSATI), superficial SATI (sSATI), visceral adipose tissue index, and ratio of visceral adipose tissue index and SATI along with skeletal muscle radiodensity, were analyzed. The correlation analyses and multiple linear regression were used to assess the impact of HVPG on BC values. The cumulative survival rate was assessed, and risk factors of survival were identified by competing risk analysis using Fine-Gray model.RESULTS:Among 173 patients with a mean age of 53.7 ± 10.5 years, there were 111 male patients (64.2%) and 62 female patients (35.8%). In male patients, SATI, dSATI, and sSATI inversely correlated with HVPG, respectively (SATI: rho = −0.227; dSATI: rho = −0.229; sSATI: rho = −0.219; all P < 0.05), especially in patients aged 60 years or younger or with compensated cirrhosis; male patients with clinically significant portal hypertension had a lower SATI, dSATI, sSATI, and skeletal muscle radiodensity than those without clinically significant portal hypertension. After adjusted multiple linear models, male sex, Child-Pugh class B or C, and elevated HVPG contributed to decreased SATI. Multiple competing survival analysis showed a lower SATI (male: <38 cm2/m2; female: <23 cm2/m2), and Child-Pugh B or C predict mortality.DISCUSSION:Decreased SATI, dSATI, and sSATI were more closely associated with increased HVPG. A lower SATI and Child-Pugh B or C predicted mortality.
Bibliografie:Correspondence: Linpeng Zhang, MD. E-mail: motank.zhang@outlook.com. Long Jin, MD. E-mail: jinlong@ccmu.edu.cn.SUPPLEMENTARY MATERIAL accompanies this paper at http://links.lww.com/CTG/B288, http://links.lww.com/CTG/B289*Siwei Yang, Xiuwan Ren, and Xiaoqing Guo contributed equally to this article.†Long Jin and Linpeng Zhang contributed equally to this article as co-corresponding authors.
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ISSN:2155-384X
2155-384X
DOI:10.14309/ctg.0000000000000836