Tumor-specific CD8 T cell characterization in HR+ breast cancer reveals an impaired antitumoral response in patients with lymph node metastasis

Most breast cancers express the estrogen receptor (ER), but the immune response of hormone receptor-positive (HR+) breast cancer remains poorly characterized. Here, dendritic cells loaded with tumor lysate are used to identify tumor-reactive CD8 T cells, which are detected in most HR+ breast cancer...

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Bibliographic Details
Published in:	Cell reports. Medicine Vol. 6; no. 8; p. 102252
Main Authors:	Pinho, Mariana Pereira, Antoun, Elie, Sandhar, Balraj, Shu, Ting, Gao, Fei, Yang, Xiaobao, Bates, Adam, Cerundolo, Lucia, Hamid, Megat H.B.A., Maldonado-Perez, David, Teague, Renuka, Warner, Eve, Winter, Lucinda, Alham, Nasullah Khalid, Verrill, Clare, Lord, Simon R., Rostron, Timothy, Clark, Sally-Ann, Waugh, Craig, Sopp, Paul, Conlon, Chris, Fernandes, Ricardo A., Harris, Adrian L., Peng, Yanchun, Adwani, Asha, Dong, Tao
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 19.08.2025 Elsevier
Subjects:	Advanced Basic Science antitumor CD8 T cells Breast Neoplasms - immunology Breast Neoplasms - pathology cancer testis antigen CD8-Positive T-Lymphocytes - immunology CDR3 CTA Dendritic Cells - immunology ER+ breast cancer Female Humans Lymph Nodes - pathology Lymphatic Metastasis - immunology Lymphocytes, Tumor-Infiltrating - immunology metastatic luminal breast cancer Middle Aged moDC Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Receptors, Estrogen - metabolism T cell receptor T cell repertoire tumor lysate tumor-specific T cells tumor lysate ER+ breast cancer CTA moDC T cell receptor T cell repertoire metastatic luminal breast cancer tumor-specific T cells antitumor CD8 T cells CDR3 cancer testis antigen
ISSN:	2666-3791, 2666-3791
Online Access:	Get full text
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