Acute supra-therapeutic oral terbutaline administration has no ergogenic effect in non-asthmatic athletes

This study aimed to investigate the effects on a possible improvement in aerobic and anaerobic performance of oral terbutaline (TER) at a supra-therapeutic dose in 7 healthy competitive male athletes. On day 1, ventilatory threshold, maximum oxygen uptake and corresponding power output were measured...

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Vydáno v:	European journal of applied physiology Ročník 113; číslo 2; s. 411 - 418
Hlavní autoři:	Sanchez, Anthony M. J., Borrani, Fabio, Le Fur, Marie Amélie, Le Mieux, Anais, Lecoultre, Virgile, Py, Guillaume, Gernigon, Christophe, Collomp, Katia, Candau, Robin
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer-Verlag 01.02.2013 Springer Nature B.V Springer Verlag
Témata:	Administration, Oral Adrenergic beta-2 Receptor Agonists - administration & dosage Adult Asthma Asthma - drug therapy Asthma - physiopathology Athletic Performance - physiology Biomedical and Life Sciences Biomedicine Bronchodilator Agents - administration & dosage Double-Blind Method Drug dosages Exercise Human Physiology Humans Life Sciences Male Occupational Medicine/Industrial Medicine Original Article Performance-Enhancing Substances - administration & dosage Physical Endurance - drug effects Physical Endurance - physiology Physical fitness Sports Medicine Terbutaline - administration & dosage Treatment Outcome France β Agonist Anaerobic performance Healthy athletes Doping Force–velocity relationship Endurance performance ENDURANCE CLENBUTEROL Force-velocity relationship PERFORMANCE beta-Agonist EXERCISE SKELETAL-MUSCLE HYPERTROPHY IMPACT POWER OUTPUT TERM SALBUTAMOL INGESTION WINGATE TEST
ISSN:	1439-6319, 1439-6327, 1439-6327
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Shrnutí:	This study aimed to investigate the effects on a possible improvement in aerobic and anaerobic performance of oral terbutaline (TER) at a supra-therapeutic dose in 7 healthy competitive male athletes. On day 1, ventilatory threshold, maximum oxygen uptake and corresponding power output were measured and used to determine the exercise load on days 2 and 3. On days 2 and 3, 8 mg of TER or placebo were orally administered in a double-blind process to athletes who rested for 3 h, and then performed a battery of tests including a force–velocity exercise test, running sprint and a maximal endurance cycling test at Δ50 % (50 % between VT and ). Lactatemia, anaerobic parameters and endurance performance ( and time until exhaustion) were raised during the corresponding tests. We found that TER administration did not improve any of the parameters of aerobic performance ( p > 0.05). In addition, no change in kinetic parameters was found with TER compared to placebo ( p > 0.05). Moreover, no enhancement of the force–velocity relationship was observed during sprint exercises after TER intake ( p > 0.05) and, on the contrary, maximal strength decreased significantly after TER intake ( p < 0.05) but maximal power remained unchanged ( p > 0.05). In conclusion, oral acute administration of TER at a supra-therapeutic dose seems to be without any relevant ergogenic effect on anaerobic and aerobic performances in healthy athletes. However, all participants experienced adverse side effects such as tremors.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	1439-6319 1439-6327 1439-6327
DOI:	10.1007/s00421-012-2447-0