Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer

Cross-talk between human epidermal growth factor receptors and hormone receptor pathways may cause endocrine resistance in breast cancer. This trial evaluated the effect of adding lapatinib, a dual tyrosine kinase inhibitor blocking epidermal growth factor receptor and human epidermal growth factor...

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Bibliographic Details
Published in:	Journal of clinical oncology Vol. 27; no. 33; p. 5538
Main Authors:	Johnston, Stephen, Pippen, Jr, John, Pivot, Xavier, Lichinitser, Mikhail, Sadeghi, Saeed, Dieras, Veronique, Gomez, Henry Leonidas, Romieu, Gilles, Manikhas, Alexey, Kennedy, M John, Press, Michael F, Maltzman, Julie, Florance, Allison, O'Rourke, Lisa, Oliva, Cristina, Stein, Steven, Pegram, Mark
Format:	Journal Article
Language:	English
Published:	United States 20.11.2009
Subjects:	Adult Aged Aged, 80 and over Antineoplastic Agents, Hormonal - administration & dosage Antineoplastic Agents, Hormonal - adverse effects Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Carcinoma - drug therapy Carcinoma - metabolism Carcinoma - mortality Carcinoma - pathology Carcinoma - secondary Disease-Free Survival Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Female Humans Kaplan-Meier Estimate Maximum Tolerated Dose Middle Aged Neoplasm Invasiveness - pathology Neoplasm Staging Nitriles - administration & dosage Nitriles - adverse effects Postmenopause - drug effects Prognosis Proportional Hazards Models Quinazolines - administration & dosage Quinazolines - adverse effects Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Receptors, Progesterone - genetics Receptors, Progesterone - metabolism Risk Assessment Survival Analysis Treatment Outcome Triazoles - administration & dosage Triazoles - adverse effects
ISSN:	1527-7755, 1527-7755
Online Access:	Get more information
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