coiTAD: Detection of Topologically Associating Domains Based on Clustering of Circular Influence Features from Hi-C Data

Background/Objectives: Topologically associating domains (TADs) are key structural units of the genome, playing a crucial role in gene regulation. TAD boundaries are enriched with specific biological markers and have been linked to genetic diseases, making consistent TAD detection essential. However...

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Veröffentlicht in:	Genes Jg. 15; H. 10; S. 1293
Hauptverfasser:	Houchens, Drew, Chowdhury, H. M. A. Mohit, Oluwadare, Oluwatosin
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 01.10.2024 MDPI
Schlagworte:	Algorithms Biomarkers Chromatin Chromatin - genetics Chromatin Assembly and Disassembly Cluster Analysis Clustering Comparative analysis Computational Biology - methods Gene regulation Genetic aspects Genetic disorders Genomes Genomic analysis Humans Identification Identification and classification Nucleotide sequence Physiological aspects Proteins Structure United States features clustering topologically associating domain TAD caller principal component analysis
ISSN:	2073-4425, 2073-4425
Online-Zugang:	Volltext
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