The Role of Long Noncoding RNA AL161431.1 in the Development and Progression of Pancreatic Cancer
Pancreatic cancer is known for its notorious fast progression and poor prognosis. Long noncoding RNA (lncRNA) AL161431.1 has been reported to be involved in the pathogenesis of different cancers. In this study, we explored the role of lncRNA AL161431.1 in the development and progression of pancreati...
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| Veröffentlicht in: | Frontiers in oncology Jg. 11; S. 666313 |
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30.07.2021
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| Abstract | Pancreatic cancer is known for its notorious fast progression and poor prognosis. Long noncoding RNA (lncRNA) AL161431.1 has been reported to be involved in the pathogenesis of different cancers. In this study, we explored the role of lncRNA AL161431.1 in the development and progression of pancreatic cancer by bioinformatic analysis,
in vitro
and
in vivo
experiments in pancreatic cancer BxPC-3 and SW1990 cells, as well as clinical samples. We found that lncRNA AL161431.1 was highly expressed in pancreatic cancer cells and tissues. Knock down of lncRNA AL161431.1 led to increased cancer cell death and cell cycle arrest. Xenograft growth of SW1990 cells with stable knockdown of lncRNA AL161431.1 in mice was significantly slower than that of SW1990 cells with scrambled control shRNA. Finally, we showed the involvement of lncRNA AL161431.1 in pancreatic cancer was related to its promotion of epithelial mesenchymal transition process. |
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| AbstractList | Pancreatic cancer is known for its notorious fast progression and poor prognosis. Long noncoding RNA (lncRNA) AL161431.1 has been reported to be involved in the pathogenesis of different cancers. In this study, we explored the role of lncRNA AL161431.1 in the development and progression of pancreatic cancer by bioinformatic analysis, in vitro and in vivo experiments in pancreatic cancer BxPC-3 and SW1990 cells, as well as clinical samples. We found that lncRNA AL161431.1 was highly expressed in pancreatic cancer cells and tissues. Knock down of lncRNA AL161431.1 led to increased cancer cell death and cell cycle arrest. Xenograft growth of SW1990 cells with stable knockdown of lncRNA AL161431.1 in mice was significantly slower than that of SW1990 cells with scrambled control shRNA. Finally, we showed the involvement of lncRNA AL161431.1 in pancreatic cancer was related to its promotion of epithelial mesenchymal transition process. Pancreatic cancer is known for its notorious fast progression and poor prognosis. Long noncoding RNA (lncRNA) AL161431.1 has been reported to be involved in the pathogenesis of different cancers. In this study, we explored the role of lncRNA AL161431.1 in the development and progression of pancreatic cancer by bioinformatic analysis, in vitro and in vivo experiments in pancreatic cancer BxPC-3 and SW1990 cells, as well as clinical samples. We found that lncRNA AL161431.1 was highly expressed in pancreatic cancer cells and tissues. Knock down of lncRNA AL161431.1 led to increased cancer cell death and cell cycle arrest. Xenograft growth of SW1990 cells with stable knockdown of lncRNA AL161431.1 in mice was significantly slower than that of SW1990 cells with scrambled control shRNA. Finally, we showed the involvement of lncRNA AL161431.1 in pancreatic cancer was related to its promotion of epithelial mesenchymal transition process. Pancreatic cancer is known for its notorious fast progression and poor prognosis. Long noncoding RNA (lncRNA) AL161431.1 has been reported to be involved in the pathogenesis of different cancers. In this study, we explored the role of lncRNA AL161431.1 in the development and progression of pancreatic cancer by bioinformatic analysis, in vitro and in vivo experiments in pancreatic cancer BxPC-3 and SW1990 cells, as well as clinical samples. We found that lncRNA AL161431.1 was highly expressed in pancreatic cancer cells and tissues. Knock down of lncRNA AL161431.1 led to increased cancer cell death and cell cycle arrest. Xenograft growth of SW1990 cells with stable knockdown of lncRNA AL161431.1 in mice was significantly slower than that of SW1990 cells with scrambled control shRNA. Finally, we showed the involvement of lncRNA AL161431.1 in pancreatic cancer was related to its promotion of epithelial mesenchymal transition process.Pancreatic cancer is known for its notorious fast progression and poor prognosis. Long noncoding RNA (lncRNA) AL161431.1 has been reported to be involved in the pathogenesis of different cancers. In this study, we explored the role of lncRNA AL161431.1 in the development and progression of pancreatic cancer by bioinformatic analysis, in vitro and in vivo experiments in pancreatic cancer BxPC-3 and SW1990 cells, as well as clinical samples. We found that lncRNA AL161431.1 was highly expressed in pancreatic cancer cells and tissues. Knock down of lncRNA AL161431.1 led to increased cancer cell death and cell cycle arrest. Xenograft growth of SW1990 cells with stable knockdown of lncRNA AL161431.1 in mice was significantly slower than that of SW1990 cells with scrambled control shRNA. Finally, we showed the involvement of lncRNA AL161431.1 in pancreatic cancer was related to its promotion of epithelial mesenchymal transition process. |
| Author | Xu, Yuanhong Liu, Zhe Fan, Wufeng Guo, Kejian Ma, Gang Song, Shaowei Li, Guichen |
| AuthorAffiliation | Department of Pancreatic-Biliary Surgery, First Hospital of China Medical University , Shenyang , China |
| AuthorAffiliation_xml | – name: Department of Pancreatic-Biliary Surgery, First Hospital of China Medical University , Shenyang , China |
| Author_xml | – sequence: 1 givenname: Gang surname: Ma fullname: Ma, Gang – sequence: 2 givenname: Guichen surname: Li fullname: Li, Guichen – sequence: 3 givenname: Wufeng surname: Fan fullname: Fan, Wufeng – sequence: 4 givenname: Yuanhong surname: Xu fullname: Xu, Yuanhong – sequence: 5 givenname: Shaowei surname: Song fullname: Song, Shaowei – sequence: 6 givenname: Kejian surname: Guo fullname: Guo, Kejian – sequence: 7 givenname: Zhe surname: Liu fullname: Liu, Zhe |
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| CitedBy_id | crossref_primary_10_1007_s13402_022_00678_5 crossref_primary_10_3389_fonc_2022_910678 crossref_primary_10_3390_cancers14235807 crossref_primary_10_2147_PGPM_S452625 crossref_primary_10_1038_s41598_024_82425_4 crossref_primary_10_3389_fmolb_2022_860323 crossref_primary_10_3389_fcimb_2021_806290 crossref_primary_10_1016_j_mcp_2023_101928 crossref_primary_10_1111_jcmm_70711 crossref_primary_10_1155_2023_9155944 crossref_primary_10_1007_s00432_023_05476_6 crossref_primary_10_3389_fonc_2023_1134456 crossref_primary_10_1155_2022_2756611 |
| Cites_doi | 10.1371/journal.pone.0096801 10.18632/aging.103244 10.1038/s41419-018-1104-x 10.1016/j.arcmed.2013.01.004 10.1007/s00432-020-03224-8 10.1093/nar/gky1055 10.1155/2019/2587109 10.1186/1476-4598-10-141 10.3389/fcell.2019.00107 10.1155/2018/6857042 10.1038/nature20149 10.26355/eurrev_202003_20495 10.3389/fonc.2020.539805 10.4161/cam.36224 10.1155/2017/9207616 10.18632/oncotarget.10545 10.3390/cells8101118 10.1038/nrm3470 10.1146/annurev.bi.63.070194.002021 10.21037/atm-21-2376 10.3389/fonc.2020.00309 10.1093/nar/gkx247 10.1093/nar/gkz1237 10.3389/fonc.2019.01526 10.1111/j.1365-2559.1987.tb02609.x 10.1186/s12885-018-4610-4 |
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| Title | The Role of Long Noncoding RNA AL161431.1 in the Development and Progression of Pancreatic Cancer |
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