Replacement of the Genomic Scaffold Improves the Replication Efficiency of Synthetic Klebsiella Phages

In this study, the impact of the genomic scaffold on the properties of bacteriophages was investigated by swapping the genomic scaffolds surrounding the tailspike genes between two Przondovirus phages, KP192 and KP195, which infect Klebsiella pneumoniae with different capsular types. A yeast-based t...

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Veröffentlicht in:	International journal of molecular sciences Jg. 26; H. 14; S. 6824
Hauptverfasser:	Baykov, Ivan K., Kurchenko, Olga M., Mikhaylova, Ekaterina E., Miroshnikova, Anna V., Morozova, Vera V., Khlebnikova, Marianna I., Tikunov, Artem Yu, Kozlova, Yuliya N., Tikunova, Nina V.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 16.07.2025 MDPI
Schlagworte:	Amino acids Bacterial pneumonia Bacteriophages - genetics Bacteriophages - physiology Biology Cloning Efficiency Genes Genome, Viral Genomes Genomics Klebsiella pneumoniae - genetics Klebsiella pneumoniae - virology Phages Pneumonia Proteins Viral Tail Proteins - genetics Virus Replication - genetics United States Massachusetts Russia Klebsiella synthetic biology receptor-binding protein transformation-associated recombination cloning tailspike depolymerase bacteriophage genome assembly
ISSN:	1422-0067, 1661-6596, 1422-0067
Online-Zugang:	Volltext
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