Human immunodeficiency virus reverse transcriptase. A kinetic analysis of RNA-dependent and DNA-dependent DNA polymerization

A minimal kinetic mechanism for HIV reverse transcriptase (RT)-catalyzed RNA-dependent and DNA-dependent DNA polymerization was determined by pre-steady-state kinetic methods to be: [formula: see text] where E, TP, dNTP, and PPi are RT, template-primer, 2'-deoxynucleoside 5'-triphosphate,...

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Bibliographic Details

Published in:	The Journal of biological chemistry Vol. 268; no. 12; p. 8743
Main Author:	Reardon, J E
Format:	Journal Article
Language:	English
Published:	United States 25.04.1993
Subjects:	Base Sequence Diphosphates - metabolism DNA, Viral - biosynthesis DNA, Viral - chemistry HIV Reverse Transcriptase HIV-1 - enzymology Kinetics Molecular Sequence Data Nucleotides - metabolism Polymers RNA, Viral - metabolism RNA-Directed DNA Polymerase - metabolism
ISSN:	0021-9258
Online Access:	Get more information
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