Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches

Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer....

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Veröffentlicht in:Frontiers in oncology Jg. 12; S. 891652
Hauptverfasser: Emran, Talha Bin, Shahriar, Asif, Mahmud, Aar Rafi, Rahman, Tanjilur, Abir, Mehedy Hasan, Siddiquee, Mohd. Faijanur - Rob, Ahmed, Hossain, Rahman, Nova, Nainu, Firzan, Wahyudin, Elly, Mitra, Saikat, Dhama, Kuldeep, Habiballah, Mahmoud M., Haque, Shafiul, Islam, Ariful, Hassan, Mohammad Mahmudul
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Frontiers Media S.A 23.06.2022
Schlagworte:
cancer
immuno-prevention
intracellular and extracellular ATP
microRNA
multidrug resistance
Oncology
ISSN:2234-943X, 2234-943X
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Abstract Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer. This review describes the known MDR mechanisms in cancer cells and discusses ongoing laboratory approaches and novel therapeutic strategies that aim to inhibit, circumvent, or reverse MDR development in various cancer types. In this review, we discuss both intrinsic and acquired drug resistance, in addition to highlighting hypoxia- and autophagy-mediated drug resistance mechanisms. Several factors, including individual genetic differences, such as mutations, altered epigenetics, enhanced drug efflux, cell death inhibition, and various other molecular and cellular mechanisms, are responsible for the development of resistance against anticancer agents. Drug resistance can also depend on cellular autophagic and hypoxic status. The expression of drug-resistant genes and the regulatory mechanisms that determine drug resistance are also discussed. Methods to circumvent MDR, including immunoprevention, the use of microparticles and nanomedicine might result in better strategies for fighting cancer.
AbstractList Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer. This review describes the known MDR mechanisms in cancer cells and discusses ongoing laboratory approaches and novel therapeutic strategies that aim to inhibit, circumvent, or reverse MDR development in various cancer types. In this review, we discuss both intrinsic and acquired drug resistance, in addition to highlighting hypoxia- and autophagy-mediated drug resistance mechanisms. Several factors, including individual genetic differences, such as mutations, altered epigenetics, enhanced drug efflux, cell death inhibition, and various other molecular and cellular mechanisms, are responsible for the development of resistance against anticancer agents. Drug resistance can also depend on cellular autophagic and hypoxic status. The expression of drug-resistant genes and the regulatory mechanisms that determine drug resistance are also discussed. Methods to circumvent MDR, including immunoprevention, the use of microparticles and nanomedicine might result in better strategies for fighting cancer.
Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer. This review describes the known MDR mechanisms in cancer cells and discusses ongoing laboratory approaches and novel therapeutic strategies that aim to inhibit, circumvent, or reverse MDR development in various cancer types. In this review, we discuss both intrinsic and acquired drug resistance, in addition to highlighting hypoxia- and autophagy-mediated drug resistance mechanisms. Several factors, including individual genetic differences, such as mutations, altered epigenetics, enhanced drug efflux, cell death inhibition, and various other molecular and cellular mechanisms, are responsible for the development of resistance against anticancer agents. Drug resistance can also depend on cellular autophagic and hypoxic status. The expression of drug-resistant genes and the regulatory mechanisms that determine drug resistance are also discussed. Methods to circumvent MDR, including immunoprevention, the use of microparticles and nanomedicine might result in better strategies for fighting cancer.Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer. This review describes the known MDR mechanisms in cancer cells and discusses ongoing laboratory approaches and novel therapeutic strategies that aim to inhibit, circumvent, or reverse MDR development in various cancer types. In this review, we discuss both intrinsic and acquired drug resistance, in addition to highlighting hypoxia- and autophagy-mediated drug resistance mechanisms. Several factors, including individual genetic differences, such as mutations, altered epigenetics, enhanced drug efflux, cell death inhibition, and various other molecular and cellular mechanisms, are responsible for the development of resistance against anticancer agents. Drug resistance can also depend on cellular autophagic and hypoxic status. The expression of drug-resistant genes and the regulatory mechanisms that determine drug resistance are also discussed. Methods to circumvent MDR, including immunoprevention, the use of microparticles and nanomedicine might result in better strategies for fighting cancer.
Author Nainu, Firzan
Hassan, Mohammad Mahmudul
Wahyudin, Elly
Dhama, Kuldeep
Rahman, Tanjilur
Rahman, Nova
Mahmud, Aar Rafi
Emran, Talha Bin
Abir, Mehedy Hasan
Ahmed, Hossain
Mitra, Saikat
Shahriar, Asif
Haque, Shafiul
Siddiquee, Mohd. Faijanur - Rob
Islam, Ariful
Habiballah, Mahmoud M.
AuthorAffiliation 9 Department of Biochemistry and Molecular Biology, Jahangirnagar University , Dhaka , Bangladesh
10 Department of Pharmacy, Faculty of Pharmacy, Hasanuddin University , Makassar , Indonesia
3 Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley , McAllen, TX , United States
7 Department of Biochemistry and Molecular Biology, University of Dhaka , Dhaka , Bangladesh
14 SMIRES for Consultation in Specialized Medical Laboratories, Jazan University , Jazan , Saudi Arabia
12 Division of Pathology, ICAR-Indian Veterinary Research Institute , Bareilly , India
15 Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University , Jazan , Saudi Arabia
19 Department of Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University , Chattogram , Bangladesh
11 Department of Pharmacy, Faculty of Pharmacy, University of Dhaka , Dhaka , Bangladesh
18 Queensland
AuthorAffiliation_xml – name: 5 Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, University of Chittagong , Chittagong , Bangladesh
– name: 12 Division of Pathology, ICAR-Indian Veterinary Research Institute , Bareilly , India
– name: 10 Department of Pharmacy, Faculty of Pharmacy, Hasanuddin University , Makassar , Indonesia
– name: 15 Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University , Jazan , Saudi Arabia
– name: 9 Department of Biochemistry and Molecular Biology, Jahangirnagar University , Dhaka , Bangladesh
– name: 4 Department of Biochemistry and Molecular Biology, Mawlana Bhashani Science and Technology University , Tangail , Bangladesh
– name: 6 Faculty of Food Science and Technology, Chattogram Veterinary and Animal Sciences University , Chattogram , Bangladesh
– name: 14 SMIRES for Consultation in Specialized Medical Laboratories, Jazan University , Jazan , Saudi Arabia
– name: 2 Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University , Dhaka , Bangladesh
– name: 18 Queensland Alliance for One Health Sciences, School of Veterinary Science, The University of Queensland , Gatton, QLD , Australia
– name: 7 Department of Biochemistry and Molecular Biology, University of Dhaka , Dhaka , Bangladesh
– name: 17 EcoHealth Alliance , New York, NY , United States
– name: 19 Department of Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University , Chattogram , Bangladesh
– name: 1 Department of Pharmacy, BGC Trust University Bangladesh , Chittagong , Bangladesh
– name: 11 Department of Pharmacy, Faculty of Pharmacy, University of Dhaka , Dhaka , Bangladesh
– name: 13 Medical Laboratory Technology Department, Jazan University , Jazan , Saudi Arabia
– name: 8 Department of Biotechnology and Genetic Engineering, University of Development Alternative , Dhaka , Bangladesh
– name: 3 Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley , McAllen, TX , United States
– name: 16 Bursa Uludağ University Faculty of Medicine , Bursa , Turkey
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  givenname: Talha Bin
  surname: Emran
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  fullname: Mitra, Saikat
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– sequence: 13
  givenname: Mahmoud M.
  surname: Habiballah
  fullname: Habiballah, Mahmoud M.
– sequence: 14
  givenname: Shafiul
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  fullname: Haque, Shafiul
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  givenname: Ariful
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  givenname: Mohammad Mahmudul
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Copyright © 2022 Emran, Shahriar, Mahmud, Rahman, Abir, Siddiquee, Ahmed, Rahman, Nainu, Wahyudin, Mitra, Dhama, Habiballah, Haque, Islam and Hassan 2022 Emran, Shahriar, Mahmud, Rahman, Abir, Siddiquee, Ahmed, Rahman, Nainu, Wahyudin, Mitra, Dhama, Habiballah, Haque, Islam and Hassan
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This article was submitted to Pharmacology of Anti-Cancer Drugs, a section of the journal Frontiers in Oncology
Reviewed by: Hodaka Fujii, Hirosaki University, Japan; Ki Hyun Nam, Pohang University of Science and Technology, South Korea; Ana Podolski-Renic, Institute for Biological Research “Siniša Stanković” – National Institute of Republic of Serbia, Serbia
Edited by: Milica Pešić, University of Belgrade, Serbia
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Snippet Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective...
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SubjectTerms cancer
immuno-prevention
intracellular and extracellular ATP
microRNA
multidrug resistance
Oncology
Title Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches
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