Compositional and Functional Adaptations of Intestinal Microbiota and Related Metabolites in CKD Patients Receiving Dietary Protein Restriction

The relationship between change of gut microbiota and host serum metabolomics associated with low protein diet (LPD) has been unraveled incompletely in CKD patients. Fecal 16S rRNA gene sequencing and serum metabolomics profiling were performed. We reported significant changes in the β-diversity of...

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Bibliographic Details
Published in:	Nutrients Vol. 12; no. 9; p. 2799
Main Authors:	Wu, I-Wen, Lee, Chin-Chan, Hsu, Heng-Jung, Sun, Chiao-Yin, Chen, Yuen-Chan, Yang, Kai-Jie, Yang, Chi-Wei, Chung, Wen-Hun, Lai, Hsin-Chih, Chang, Lun-Ching, Su, Shih-Chi
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 12.09.2020 MDPI
Subjects:	Adaptation, Physiological Aged Bacteroidaceae bile acids Bile Acids and Salts - metabolism blood serum butyrates Diet Diet, Protein-Restricted - methods dietary protein Dietitians Discriminant analysis Fatty acids Feces - microbiology Female Gastrointestinal Microbiome - physiology genes Glomerular Filtration Rate glutathione Humans intestinal microorganisms Lachnospiraceae low protein diet Male metabolism Metabolites Metabolome - physiology Metabolomics Microbiota Middle Aged pelargonic acid Phylogenetics Probiotics Proteins Renal Insufficiency, Chronic - diet therapy Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - microbiology RNA, Ribosomal, 16S Software sulfates Vegetarianism United States > US low protein diet uremic solute chronic kidney disease gut microbiome short-chain fatty acids bile acids
ISSN:	2072-6643, 2072-6643
Online Access:	Get full text
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