Compositional and Functional Adaptations of Intestinal Microbiota and Related Metabolites in CKD Patients Receiving Dietary Protein Restriction

The relationship between change of gut microbiota and host serum metabolomics associated with low protein diet (LPD) has been unraveled incompletely in CKD patients. Fecal 16S rRNA gene sequencing and serum metabolomics profiling were performed. We reported significant changes in the β-diversity of...

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Published in:Nutrients Vol. 12; no. 9; p. 2799
Main Authors: Wu, I-Wen, Lee, Chin-Chan, Hsu, Heng-Jung, Sun, Chiao-Yin, Chen, Yuen-Chan, Yang, Kai-Jie, Yang, Chi-Wei, Chung, Wen-Hun, Lai, Hsin-Chih, Chang, Lun-Ching, Su, Shih-Chi
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 12.09.2020
MDPI
Subjects:
Adaptation, Physiological
Aged
Bacteroidaceae
bile acids
Bile Acids and Salts - metabolism
blood serum
butyrates
Diet
Diet, Protein-Restricted - methods
dietary protein
Dietitians
Discriminant analysis
Fatty acids
Feces - microbiology
Female
Gastrointestinal Microbiome - physiology
genes
Glomerular Filtration Rate
glutathione
Humans
intestinal microorganisms
Lachnospiraceae
low protein diet
Male
metabolism
Metabolites
Metabolome - physiology
Metabolomics
Microbiota
Middle Aged
pelargonic acid
Phylogenetics
Probiotics
Proteins
Renal Insufficiency, Chronic - diet therapy
Renal Insufficiency, Chronic - metabolism
Renal Insufficiency, Chronic - microbiology
RNA, Ribosomal, 16S
Software
sulfates
Vegetarianism
United States > US
low protein diet
uremic solute
chronic kidney disease
gut microbiome
short-chain fatty acids
bile acids
ISSN:2072-6643, 2072-6643
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Abstract The relationship between change of gut microbiota and host serum metabolomics associated with low protein diet (LPD) has been unraveled incompletely in CKD patients. Fecal 16S rRNA gene sequencing and serum metabolomics profiling were performed. We reported significant changes in the β-diversity of gut microbiota in CKD patients having LPD (CKD-LPD, n = 16). We identified 19 genera and 12 species with significant differences in their relative abundance among CKD-LPD patients compared to patients receiving normal protein diet (CKD-NPD, n = 27) or non-CKD controls (n = 34), respectively. CKD-LPD had a significant decrease in the abundance of many butyrate-producing bacteria (family Lachnospiraceae and Bacteroidaceae) associated with enrichment of functional module of butanoate metabolism, leading to concomitant reduction in serum levels of SCFA (acetic, heptanoic and nonanoic acid). A secondary bile acid, glyco λ-muricholic acid, was significantly increased in CKD-LPD patients. Serum levels of indoxyl sulfate and p-cresyl sulfate did not differ among groups. The relationship between abundances of microbes and metabolites remained significant in subset of resampling subjects of comparable characteristics. Enrichment of bacterial gene markers related to D-alanine, ketone bodies and glutathione metabolism was noted in CKD-LPD patients. Our analyses reveal signatures and functions of gut microbiota to adapt dietary protein restriction in renal patients.
AbstractList The relationship between change of gut microbiota and host serum metabolomics associated with low protein diet (LPD) has been unraveled incompletely in CKD patients. Fecal 16S rRNA gene sequencing and serum metabolomics profiling were performed. We reported significant changes in the β-diversity of gut microbiota in CKD patients having LPD (CKD-LPD, n = 16). We identified 19 genera and 12 species with significant differences in their relative abundance among CKD-LPD patients compared to patients receiving normal protein diet (CKD-NPD, n = 27) or non-CKD controls (n = 34), respectively. CKD-LPD had a significant decrease in the abundance of many butyrate-producing bacteria (family Lachnospiraceae and Bacteroidaceae) associated with enrichment of functional module of butanoate metabolism, leading to concomitant reduction in serum levels of SCFA (acetic, heptanoic and nonanoic acid). A secondary bile acid, glyco λ-muricholic acid, was significantly increased in CKD-LPD patients. Serum levels of indoxyl sulfate and p-cresyl sulfate did not differ among groups. The relationship between abundances of microbes and metabolites remained significant in subset of resampling subjects of comparable characteristics. Enrichment of bacterial gene markers related to D-alanine, ketone bodies and glutathione metabolism was noted in CKD-LPD patients. Our analyses reveal signatures and functions of gut microbiota to adapt dietary protein restriction in renal patients.
The relationship between change of gut microbiota and host serum metabolomics associated with low protein diet (LPD) has been unraveled incompletely in CKD patients. Fecal 16S rRNA gene sequencing and serum metabolomics profiling were performed. We reported significant changes in the β-diversity of gut microbiota in CKD patients having LPD (CKD-LPD, = 16). We identified 19 genera and 12 species with significant differences in their relative abundance among CKD-LPD patients compared to patients receiving normal protein diet (CKD-NPD, = 27) or non-CKD controls ( = 34), respectively. CKD-LPD had a significant decrease in the abundance of many butyrate-producing bacteria (family and ) associated with enrichment of functional module of butanoate metabolism, leading to concomitant reduction in serum levels of SCFA (acetic, heptanoic and nonanoic acid). A secondary bile acid, glyco λ-muricholic acid, was significantly increased in CKD-LPD patients. Serum levels of indoxyl sulfate and p-cresyl sulfate did not differ among groups. The relationship between abundances of microbes and metabolites remained significant in subset of resampling subjects of comparable characteristics. Enrichment of bacterial gene markers related to D-alanine, ketone bodies and glutathione metabolism was noted in CKD-LPD patients. Our analyses reveal signatures and functions of gut microbiota to adapt dietary protein restriction in renal patients.
The relationship between change of gut microbiota and host serum metabolomics associated with low protein diet (LPD) has been unraveled incompletely in CKD patients. Fecal 16S rRNA gene sequencing and serum metabolomics profiling were performed. We reported significant changes in the β-diversity of gut microbiota in CKD patients having LPD (CKD-LPD, n = 16). We identified 19 genera and 12 species with significant differences in their relative abundance among CKD-LPD patients compared to patients receiving normal protein diet (CKD-NPD, n = 27) or non-CKD controls (n = 34), respectively. CKD-LPD had a significant decrease in the abundance of many butyrate-producing bacteria (family Lachnospiraceae and Bacteroidaceae) associated with enrichment of functional module of butanoate metabolism, leading to concomitant reduction in serum levels of SCFA (acetic, heptanoic and nonanoic acid). A secondary bile acid, glyco λ-muricholic acid, was significantly increased in CKD-LPD patients. Serum levels of indoxyl sulfate and p-cresyl sulfate did not differ among groups. The relationship between abundances of microbes and metabolites remained significant in subset of resampling subjects of comparable characteristics. Enrichment of bacterial gene markers related to D-alanine, ketone bodies and glutathione metabolism was noted in CKD-LPD patients. Our analyses reveal signatures and functions of gut microbiota to adapt dietary protein restriction in renal patients.The relationship between change of gut microbiota and host serum metabolomics associated with low protein diet (LPD) has been unraveled incompletely in CKD patients. Fecal 16S rRNA gene sequencing and serum metabolomics profiling were performed. We reported significant changes in the β-diversity of gut microbiota in CKD patients having LPD (CKD-LPD, n = 16). We identified 19 genera and 12 species with significant differences in their relative abundance among CKD-LPD patients compared to patients receiving normal protein diet (CKD-NPD, n = 27) or non-CKD controls (n = 34), respectively. CKD-LPD had a significant decrease in the abundance of many butyrate-producing bacteria (family Lachnospiraceae and Bacteroidaceae) associated with enrichment of functional module of butanoate metabolism, leading to concomitant reduction in serum levels of SCFA (acetic, heptanoic and nonanoic acid). A secondary bile acid, glyco λ-muricholic acid, was significantly increased in CKD-LPD patients. Serum levels of indoxyl sulfate and p-cresyl sulfate did not differ among groups. The relationship between abundances of microbes and metabolites remained significant in subset of resampling subjects of comparable characteristics. Enrichment of bacterial gene markers related to D-alanine, ketone bodies and glutathione metabolism was noted in CKD-LPD patients. Our analyses reveal signatures and functions of gut microbiota to adapt dietary protein restriction in renal patients.
Author Yang, Chi-Wei
Su, Shih-Chi
Hsu, Heng-Jung
Lai, Hsin-Chih
Chang, Lun-Ching
Sun, Chiao-Yin
Wu, I-Wen
Lee, Chin-Chan
Chen, Yuen-Chan
Yang, Kai-Jie
Chung, Wen-Hun
AuthorAffiliation 5 Department of Medical Biotechnology and Laboratory Science and Microbiota Research Center, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan; hclai@mail.cgu.edu.tw
4 Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung 20401, Taiwan; chung1@cgmh.org.tw
7 Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou 33305, Taiwan
6 Department of Mathematical Sciences, Florida Atlantic University, Boca Raton, FL 33431, USA
1 Department of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan; fliawu@yahoo.com (I.-W.W.); leefang@cgmh.org.tw (C.-C.L.); r5267@cgmh.org.tw (H.-J.H.); fish3970@gmail.com (C.-Y.S.); eva90156@cgmh.org.tw (K.-J.Y.)
3 Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkuo 33305, Taiwan
2 College of Medicine, Chang Gung University, Taoyuan 33305, Taiwan; cyc2356@cgmh.org.tw (Y.-C.C.); cwyang00@gmail.com (C.-W.Y.)
AuthorAffiliation_xml – name: 1 Department of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan; fliawu@yahoo.com (I.-W.W.); leefang@cgmh.org.tw (C.-C.L.); r5267@cgmh.org.tw (H.-J.H.); fish3970@gmail.com (C.-Y.S.); eva90156@cgmh.org.tw (K.-J.Y.)
– name: 2 College of Medicine, Chang Gung University, Taoyuan 33305, Taiwan; cyc2356@cgmh.org.tw (Y.-C.C.); cwyang00@gmail.com (C.-W.Y.)
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– name: 6 Department of Mathematical Sciences, Florida Atlantic University, Boca Raton, FL 33431, USA
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/32932711$$D View this record in MEDLINE/PubMed
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Cites_doi 10.3390/nu11050957
10.1080/19490976.2019.1674124
10.1016/j.lfs.2015.12.050
10.7150/ijbs.37421
10.1038/ki.2015.255
10.1007/s10157-018-1591-1
10.3390/nu11123006
10.1159/000360010
10.1056/NEJM199403313301301
10.3390/jcm8091424
10.1681/ASN.2015040369
10.1038/nmeth.2604
10.1126/science.aau5812
10.1016/j.cmet.2013.01.003
10.1056/NEJMra1700312
10.7150/thno.41725
10.1016/j.cmet.2016.05.005
10.1093/ndt/gfx029
10.1038/ncomms3384
10.1007/s11154-019-09518-8
10.1093/nar/gkr1044
10.1016/j.kint.2016.06.033
10.1042/CS20190171
10.1053/j.jrn.2017.11.007
10.7717/peerj.7145
10.1093/nar/gks1219
10.1016/j.jfda.2018.10.008
10.1128/AEM.03006-05
10.1080/01621459.1952.10483441
10.1038/s41467-018-05901-2
10.1007/s00018-019-03155-9
10.1007/s11255-014-0901-0
10.1023/A:1010933404324
10.1126/science.1208344
10.1016/j.kint.2020.01.028
10.1038/ki.2012.345
10.1038/nbt.2676
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Issue 9
Keywords low protein diet
uremic solute
chronic kidney disease
gut microbiome
short-chain fatty acids
bile acids
Language English
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References Quast (ref_15) 2013; 41
Lin (ref_12) 2019; 27
Koppe (ref_36) 2015; 88
ref_10
Milovanova (ref_4) 2018; 22
Wu (ref_13) 2020; 16
ref_16
Feng (ref_22) 2019; 76
Wahlstrom (ref_32) 2016; 24
Wang (ref_27) 2019; 133
Li (ref_33) 2013; 4
Garneata (ref_1) 2016; 27
Markowitz (ref_18) 2012; 40
Winston (ref_31) 2019; 11
Tinahones (ref_38) 2019; 20
Vaziri (ref_23) 2013; 83
Sun (ref_25) 2018; 9
Wong (ref_28) 2014; 39
Li (ref_30) 2019; 7
Langille (ref_17) 2013; 31
Sayin (ref_34) 2013; 17
Yamada (ref_6) 2016; 146
Chu (ref_29) 2015; 47
Nazzal (ref_35) 2017; 32
Gryp (ref_37) 2020; 97
ref_24
Klahr (ref_3) 1994; 330
Wu (ref_11) 2020; 10
Black (ref_9) 2018; 28
ref_2
Wu (ref_8) 2011; 334
Pluznick (ref_26) 2016; 90
Fouque (ref_5) 2017; 377
Kruskal (ref_20) 1952; 47
Gentile (ref_7) 2018; 362
DeSantis (ref_19) 2006; 72
Breiman (ref_21) 2001; 45
Edgar (ref_14) 2013; 10
References_xml – ident: ref_2
  doi: 10.3390/nu11050957
– volume: 11
  start-page: 158
  year: 2019
  ident: ref_31
  article-title: Diversification of host bile acids by members of the gut microbiota
  publication-title: Gut Microbes
  doi: 10.1080/19490976.2019.1674124
– volume: 146
  start-page: 117
  year: 2016
  ident: ref_6
  article-title: Very low protein diet enhances inflammation, malnutrition, and vascular calcification in uremic rats
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2015.12.050
– volume: 16
  start-page: 420
  year: 2020
  ident: ref_13
  article-title: Gut microbiota as diagnostic tools for mirroring disease progression and circulating nephrotoxin levels in chronic kidney disease: Discovery and validation study
  publication-title: Int. J. Biol. Sci.
  doi: 10.7150/ijbs.37421
– volume: 88
  start-page: 958
  year: 2015
  ident: ref_36
  article-title: Probiotics and chronic kidney disease
  publication-title: Kidney Int.
  doi: 10.1038/ki.2015.255
– volume: 22
  start-page: 1351
  year: 2018
  ident: ref_4
  article-title: Effect of essential amino acid кetoanalogues and protein restriction diet on morphogenetic proteins (FGF-23 and Кlotho) in 3b-4 stages chronic кidney disease patients: A randomized pilot study
  publication-title: Clin. Exp. Nephrol.
  doi: 10.1007/s10157-018-1591-1
– ident: ref_24
  doi: 10.3390/nu11123006
– volume: 39
  start-page: 230
  year: 2014
  ident: ref_28
  article-title: Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in esrd
  publication-title: Am. J. Nephrol.
  doi: 10.1159/000360010
– volume: 330
  start-page: 877
  year: 1994
  ident: ref_3
  article-title: The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease. Modification of diet in renal disease study group
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM199403313301301
– ident: ref_16
– ident: ref_10
  doi: 10.3390/jcm8091424
– volume: 27
  start-page: 2164
  year: 2016
  ident: ref_1
  article-title: Ketoanalogue-supplemented vegetarian very low-protein diet and ckd progression
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2015040369
– volume: 10
  start-page: 996
  year: 2013
  ident: ref_14
  article-title: Uparse: Highly accurate otu sequences from microbial amplicon reads
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2604
– volume: 362
  start-page: 776
  year: 2018
  ident: ref_7
  article-title: The gut microbiota at the intersection of diet and human health
  publication-title: Science
  doi: 10.1126/science.aau5812
– volume: 17
  start-page: 225
  year: 2013
  ident: ref_34
  article-title: Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring fxr antagonist
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2013.01.003
– volume: 377
  start-page: 1765
  year: 2017
  ident: ref_5
  article-title: Nutritional management of chronic kidney disease
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMra1700312
– volume: 10
  start-page: 5398
  year: 2020
  ident: ref_11
  article-title: Integrative metagenomic and metabolomic analyses reveal severity-specific signatures of gut microbiota in chronic kidney disease
  publication-title: Theranostics
  doi: 10.7150/thno.41725
– volume: 24
  start-page: 41
  year: 2016
  ident: ref_32
  article-title: Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2016.05.005
– volume: 32
  start-page: 1809
  year: 2017
  ident: ref_35
  article-title: Microbiome perturbation by oral vancomycin reduces plasma concentration of two gut-derived uremic solutes, indoxyl sulfate and p-cresyl sulfate, in end-stage renal disease
  publication-title: Nephrol. Dial. Transplant.
  doi: 10.1093/ndt/gfx029
– volume: 4
  start-page: 2384
  year: 2013
  ident: ref_33
  article-title: Microbiome remodelling leads to inhibition of intestinal farnesoid x receptor signalling and decreased obesity
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms3384
– volume: 20
  start-page: 415
  year: 2019
  ident: ref_38
  article-title: Keto microbiota: A powerful contributor to host disease recovery
  publication-title: Rev. Endocr. Metab. Disord.
  doi: 10.1007/s11154-019-09518-8
– volume: 40
  start-page: D115
  year: 2012
  ident: ref_18
  article-title: Img: The integrated microbial genomes database and comparative analysis system
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkr1044
– volume: 90
  start-page: 1191
  year: 2016
  ident: ref_26
  article-title: Gut microbiota in renal physiology: Focus on short-chain fatty acids and their receptors
  publication-title: Kidney Int.
  doi: 10.1016/j.kint.2016.06.033
– volume: 133
  start-page: 1857
  year: 2019
  ident: ref_27
  article-title: Quantitative reduction in short-chain fatty acids, especially butyrate, contributes to the progression of chronic kidney disease
  publication-title: Clin. Sci.
  doi: 10.1042/CS20190171
– volume: 28
  start-page: 208
  year: 2018
  ident: ref_9
  article-title: Does low-protein diet influence the uremic toxin serum levels from the gut microbiota in nondialysis chronic kidney disease patients?
  publication-title: J. Ren. Nutr.
  doi: 10.1053/j.jrn.2017.11.007
– volume: 7
  start-page: e7145
  year: 2019
  ident: ref_30
  article-title: Targeted metabolomics study of serum bile acid profile in patients with end-stage renal disease undergoing hemodialysis
  publication-title: PeerJ
  doi: 10.7717/peerj.7145
– volume: 41
  start-page: D590
  year: 2013
  ident: ref_15
  article-title: The silva ribosomal rna gene database project: Improved data processing and web-based tools
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gks1219
– volume: 27
  start-page: 502
  year: 2019
  ident: ref_12
  article-title: Measuring serum total and free indoxyl sulfate and p-cresyl sulfate in chronic kidney disease using uplc-ms/ms
  publication-title: J. Food Drug Anal.
  doi: 10.1016/j.jfda.2018.10.008
– volume: 72
  start-page: 5069
  year: 2006
  ident: ref_19
  article-title: Greengenes, a chimera-checked 16s rrna gene database and workbench compatible with arb
  publication-title: Appl. Environ. Microbiol.
  doi: 10.1128/AEM.03006-05
– volume: 47
  start-page: 583
  year: 1952
  ident: ref_20
  article-title: Use of ranks in one-criterion variance analysis
  publication-title: J. Am. Stat. Assoc.
  doi: 10.1080/01621459.1952.10483441
– volume: 9
  start-page: 3555
  year: 2018
  ident: ref_25
  article-title: Microbiota-derived short-chain fatty acids promote th1 cell il-10 production to maintain intestinal homeostasis
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-05901-2
– volume: 76
  start-page: 4961
  year: 2019
  ident: ref_22
  article-title: Microbiome-metabolomics reveals gut microbiota associated with glycine-conjugated metabolites and polyamine metabolism in chronic kidney disease
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-019-03155-9
– volume: 47
  start-page: 345
  year: 2015
  ident: ref_29
  article-title: Mechanism underlying an elevated serum bile acid level in chronic renal failure patients
  publication-title: Int. Urol. Nephrol.
  doi: 10.1007/s11255-014-0901-0
– volume: 45
  start-page: 5
  year: 2001
  ident: ref_21
  article-title: Random forests
  publication-title: Mach. Learn.
  doi: 10.1023/A:1010933404324
– volume: 334
  start-page: 105
  year: 2011
  ident: ref_8
  article-title: Linking long-term dietary patterns with gut microbial enterotypes
  publication-title: Science
  doi: 10.1126/science.1208344
– volume: 97
  start-page: 1230
  year: 2020
  ident: ref_37
  article-title: Gut microbiota generation of protein-bound uremic toxins and related metabolites is not altered at different stages of chronic kidney disease
  publication-title: Kidney Int.
  doi: 10.1016/j.kint.2020.01.028
– volume: 83
  start-page: 308
  year: 2013
  ident: ref_23
  article-title: Chronic kidney disease alters intestinal microbial flora
  publication-title: Kidney Int.
  doi: 10.1038/ki.2012.345
– volume: 31
  start-page: 814
  year: 2013
  ident: ref_17
  article-title: Predictive functional profiling of microbial communities using 16s rrna marker gene sequences
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2676
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Snippet The relationship between change of gut microbiota and host serum metabolomics associated with low protein diet (LPD) has been unraveled incompletely in CKD...
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StartPage 2799
SubjectTerms Adaptation, Physiological
Aged
Bacteroidaceae
bile acids
Bile Acids and Salts - metabolism
blood serum
butyrates
Diet
Diet, Protein-Restricted - methods
dietary protein
Dietitians
Discriminant analysis
Fatty acids
Feces - microbiology
Female
Gastrointestinal Microbiome - physiology
genes
Glomerular Filtration Rate
glutathione
Humans
intestinal microorganisms
Lachnospiraceae
low protein diet
Male
metabolism
Metabolites
Metabolome - physiology
Metabolomics
Microbiota
Middle Aged
pelargonic acid
Phylogenetics
Probiotics
Proteins
Renal Insufficiency, Chronic - diet therapy
Renal Insufficiency, Chronic - metabolism
Renal Insufficiency, Chronic - microbiology
RNA, Ribosomal, 16S
Software
sulfates
Vegetarianism
Title Compositional and Functional Adaptations of Intestinal Microbiota and Related Metabolites in CKD Patients Receiving Dietary Protein Restriction
URI https://www.ncbi.nlm.nih.gov/pubmed/32932711
https://www.proquest.com/docview/2443222753
https://www.proquest.com/docview/2443522665
https://www.proquest.com/docview/2524242852
https://pubmed.ncbi.nlm.nih.gov/PMC7551076
Volume 12
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