Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

T follicular helper (Tfh) cells are required to develop germinal center (GC) responses and drive immunoglobulin class switch, affinity maturation, and long-term B cell memory. In this study, we characterize a recently developed vaccine platform, nucleoside-modified, purified mRNA encapsulated in lip...

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Vydané v:	The Journal of experimental medicine Ročník 215; číslo 6; s. 1571
Hlavní autori:	Pardi, Norbert, Hogan, Michael J, Naradikian, Martin S, Parkhouse, Kaela, Cain, Derek W, Jones, Letitia, Moody, M Anthony, Verkerke, Hans P, Myles, Arpita, Willis, Elinor, LaBranche, Celia C, Montefiori, David C, Lobby, Jenna L, Saunders, Kevin O, Liao, Hua-Xin, Korber, Bette T, Sutherland, Laura L, Scearce, Richard M, Hraber, Peter T, Tombácz, István, Muramatsu, Hiromi, Ni, Houping, Balikov, Daniel A, Li, Charles, Mui, Barbara L, Tam, Ying K, Krammer, Florian, Karikó, Katalin, Polacino, Patricia, Eisenlohr, Laurence C, Madden, Thomas D, Hope, Michael J, Lewis, Mark G, Lee, Kelly K, Hu, Shiu-Lok, Hensley, Scott E, Cancro, Michael P, Haynes, Barton F, Weissman, Drew
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 04.06.2018
Predmet:	Adjuvants, Immunologic - pharmacology Animals Antibodies, Neutralizing - immunology Antibody Formation - immunology Antigens - metabolism B-Lymphocytes - immunology Germinal Center - cytology Lipids - chemistry Macaca mulatta Nanoparticles - chemistry Nucleosides - metabolism Protein Subunits - metabolism RNA, Messenger - metabolism T-Lymphocytes, Helper-Inducer - immunology Time Factors Vaccination Vaccines, Subunit - immunology
ISSN:	1540-9538, 1540-9538
On-line prístup:	Zistit podrobnosti o prístupe
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