Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

T follicular helper (Tfh) cells are required to develop germinal center (GC) responses and drive immunoglobulin class switch, affinity maturation, and long-term B cell memory. In this study, we characterize a recently developed vaccine platform, nucleoside-modified, purified mRNA encapsulated in lip...

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Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 215; no. 6; p. 1571
Main Authors:	Pardi, Norbert, Hogan, Michael J, Naradikian, Martin S, Parkhouse, Kaela, Cain, Derek W, Jones, Letitia, Moody, M Anthony, Verkerke, Hans P, Myles, Arpita, Willis, Elinor, LaBranche, Celia C, Montefiori, David C, Lobby, Jenna L, Saunders, Kevin O, Liao, Hua-Xin, Korber, Bette T, Sutherland, Laura L, Scearce, Richard M, Hraber, Peter T, Tombácz, István, Muramatsu, Hiromi, Ni, Houping, Balikov, Daniel A, Li, Charles, Mui, Barbara L, Tam, Ying K, Krammer, Florian, Karikó, Katalin, Polacino, Patricia, Eisenlohr, Laurence C, Madden, Thomas D, Hope, Michael J, Lewis, Mark G, Lee, Kelly K, Hu, Shiu-Lok, Hensley, Scott E, Cancro, Michael P, Haynes, Barton F, Weissman, Drew
Format:	Journal Article
Language:	English
Published:	United States 04.06.2018
Subjects:	Adjuvants, Immunologic - pharmacology Animals Antibodies, Neutralizing - immunology Antibody Formation - immunology Antigens - metabolism B-Lymphocytes - immunology Germinal Center - cytology Lipids - chemistry Macaca mulatta Nanoparticles - chemistry Nucleosides - metabolism Protein Subunits - metabolism RNA, Messenger - metabolism T-Lymphocytes, Helper-Inducer - immunology Time Factors Vaccination Vaccines, Subunit - immunology
ISSN:	1540-9538, 1540-9538
Online Access:	Get more information
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