Antioxidant and anti-inflammatory activities of quercetin and its derivatives

•Antioxidant and anti-inflammatory activities of quercetin derivatives were studied.•Quercetin metabolites present in systemic circulation have potent biopotential.•Derivatization quercetin resulted in decrease of antioxidant activity.•Derivatization of quercetin does not significantly defines anti-...

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Bibliographic Details
Published in:Journal of functional foods Vol. 40; pp. 68 - 75
Main Authors: Lesjak, Marija, Beara, Ivana, Simin, Nataša, Pintać, Diandra, Majkić, Tatjana, Bekvalac, Kristina, Orčić, Dejan, Mimica-Dukić, Neda
Format: Journal Article
Language:English
Published: Elsevier Ltd 01.01.2018
Subjects:
Anti-inflammatory activity
anti-inflammatory agents
Antioxidant activity
antioxidants
aspirin
butylated hydroxytoluene
derivatization
food intake
isorhamnetin
metabolites
onions
Quercetin
Quercetin derivatives
Quercetin glycosides
AA
PGE2
q-5methyl
DPPH
LP
q-glucuronide
12-HETE
COX-1
DMSO
Antioxidant activity
Quercetin glycosides
BHT
SD
TXB2
iso-glucoside
q-diglucoside
Quercetin
Anti-inflammatory activity
12-LOX
FRAP
12-HHT
Quercetin derivatives
ISSN:1756-4646, 2214-9414
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Summary:•Antioxidant and anti-inflammatory activities of quercetin derivatives were studied.•Quercetin metabolites present in systemic circulation have potent biopotential.•Derivatization quercetin resulted in decrease of antioxidant activity.•Derivatization of quercetin does not significantly defines anti-inflammatory potential.•Metabolites should be included in defining biopotential of quercetin-rich diet. Quercetin is hardly bioavailable and largely transformed to different metabolites. Although little is known about their biological activities, these metabolites are crucial for explanation of health benefits associated with quercetin dietary intake. In this study, the antioxidant and anti-inflammatory activities of six quercetin derivatives (quercetin-3-O-glucuronide, tamarixetin, isorhamnetin, isorhamnetin-3-O-glucoside, quercetin-3,4′-di-O-glucoside, quercetin-3,5,7,3′,4′-pentamethylether) were compared with the activity of common onion extract as the main source of dietary quercetin and standards (butylated hydroxytoluene and aspirin). The quercetin derivatives demonstrated notable bioactivities, similar to standards and onion. Derivatization of quercetin hydroxyl groups resulted in decrease of antioxidant potency. However, the number of quercetin free hydroxyl groups was not in direct correlation with its potential to inhibit inflammatory mediators production. To conclude, quercetin derivatives present in systemic circulation after consumption of quercetin may act as potent antioxidant and anti-inflammatory agents and can contribute to overall biological activity of quercetin-rich diet.
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ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2017.10.047