Development and in vitro evaluation of κ-carrageenan based polymeric hybrid nanocomposite scaffolds for bone tissue engineering

The excellent biocompatible and osteogenesis characteristics of porous scaffolds play a vital role in bone regeneration. In this study, we have synthesized polymeric hybrid nanocomposites via free-radical polymerization from carrageenan/acrylic-acid/graphene/hydroxyapatite. Porous hybrid nanocomposi...

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Veröffentlicht in:RSC advances Jg. 10; H. 66; S. 40529 - 40542
Hauptverfasser: Aslam Khan, Muhammad Umar, Raza, Mohsin Ali, Mehboob, Hassan, Abdul Kadir, Mohammed Rafiq, Abd Razak, Saiful Izwan, Shah, Saqlain A., Iqbal, Muhammad Zahir, Amin, Rashid
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Royal Society of Chemistry 06.11.2020
The Royal Society of Chemistry
Schlagworte:
absorbance
Biocompatibility
Biodegradation
Biomedical materials
bone formation
bones
Carrageenan
Cell adhesion
cell culture
cell viability
Chemical composition
Chemistry
compression strength
Compressive strength
Contact angle
dyes
Fourier transform infrared spectroscopy
Fourier transforms
Free radical polymerization
freeze drying
Functional groups
Graphene
hydrophilicity
Hydroxyapatite
Mechanical properties
mice
Modulus of elasticity
Morphology
Nanocomposites
Optical density
polymerization
polymers
Pore size
Porosity
Regeneration (physiology)
Scaffolds
Scanning electron microscopy
Swelling
Tissue engineering
ISSN:2046-2069, 2046-2069
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Abstract The excellent biocompatible and osteogenesis characteristics of porous scaffolds play a vital role in bone regeneration. In this study, we have synthesized polymeric hybrid nanocomposites via free-radical polymerization from carrageenan/acrylic-acid/graphene/hydroxyapatite. Porous hybrid nanocomposite scaffolds were fabricated through a freeze-drying method to mimic the structural and chemical composition of natural bone. Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and water contact-angle studies were carried-out for functional groups, surface morphology and hydrophilicity of the materials, followed by biodegradation and swelling analysis. The cell viability, cell culture and proliferation were evaluated against mouse pre-osteoblast ( MC3T3-E1 ) cell lines using neutral red dye assay. The cell adherence and proliferation studies were determined by SEM. Physical characterization including optimum porosity and pore size (49.75% and 0.41 × 10 3 μm 2 ), mechanical properties (compression strength 8.87 MPa and elastic modulus 442.63 MPa), swelling (70.20% at 27 °C and 77.21% at 37 °C) and biodegradation (23.8%) were performed. The results indicated CG- g -AAc-3 with a high optical density and better cell viability. Hence, CG- g -AAc-3 was found to be more efficient for bone regeneration with potential applications in fractured bone regeneration.
AbstractList The excellent biocompatible and osteogenesis characteristics of porous scaffolds play a vital role in bone regeneration. In this study, we have synthesized polymeric hybrid nanocomposites free-radical polymerization from carrageenan/acrylic-acid/graphene/hydroxyapatite. Porous hybrid nanocomposite scaffolds were fabricated through a freeze-drying method to mimic the structural and chemical composition of natural bone. Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and water contact-angle studies were carried-out for functional groups, surface morphology and hydrophilicity of the materials, followed by biodegradation and swelling analysis. The cell viability, cell culture and proliferation were evaluated against mouse pre-osteoblast ( ) cell lines using neutral red dye assay. The cell adherence and proliferation studies were determined by SEM. Physical characterization including optimum porosity and pore size (49.75% and 0.41 × 10 μm ), mechanical properties (compression strength 8.87 MPa and elastic modulus 442.63 MPa), swelling (70.20% at 27 °C and 77.21% at 37 °C) and biodegradation (23.8%) were performed. The results indicated CG- -AAc-3 with a high optical density and better cell viability. Hence, CG- -AAc-3 was found to be more efficient for bone regeneration with potential applications in fractured bone regeneration.
The excellent biocompatible and osteogenesis characteristics of porous scaffolds play a vital role in bone regeneration. In this study, we have synthesized polymeric hybrid nanocomposites via free-radical polymerization from carrageenan/acrylic-acid/graphene/hydroxyapatite. Porous hybrid nanocomposite scaffolds were fabricated through a freeze-drying method to mimic the structural and chemical composition of natural bone. Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and water contact-angle studies were carried-out for functional groups, surface morphology and hydrophilicity of the materials, followed by biodegradation and swelling analysis. The cell viability, cell culture and proliferation were evaluated against mouse pre-osteoblast ( MC3T3-E1 ) cell lines using neutral red dye assay. The cell adherence and proliferation studies were determined by SEM. Physical characterization including optimum porosity and pore size (49.75% and 0.41 × 10 3 μm 2 ), mechanical properties (compression strength 8.87 MPa and elastic modulus 442.63 MPa), swelling (70.20% at 27 °C and 77.21% at 37 °C) and biodegradation (23.8%) were performed. The results indicated CG- g -AAc-3 with a high optical density and better cell viability. Hence, CG- g -AAc-3 was found to be more efficient for bone regeneration with potential applications in fractured bone regeneration.
The excellent biocompatible and osteogenesis characteristics of porous scaffolds play a vital role in bone regeneration. In this study, we have synthesized polymeric hybrid nanocomposites via free-radical polymerization from carrageenan/acrylic-acid/graphene/hydroxyapatite. Porous hybrid nanocomposite scaffolds were fabricated through a freeze-drying method to mimic the structural and chemical composition of natural bone. Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and water contact-angle studies were carried-out for functional groups, surface morphology and hydrophilicity of the materials, followed by biodegradation and swelling analysis. The cell viability, cell culture and proliferation were evaluated against mouse pre-osteoblast (MC3T3-E1) cell lines using neutral red dye assay. The cell adherence and proliferation studies were determined by SEM. Physical characterization including optimum porosity and pore size (49.75% and 0.41 × 103 μm2), mechanical properties (compression strength 8.87 MPa and elastic modulus 442.63 MPa), swelling (70.20% at 27 °C and 77.21% at 37 °C) and biodegradation (23.8%) were performed. The results indicated CG-g-AAc-3 with a high optical density and better cell viability. Hence, CG-g-AAc-3 was found to be more efficient for bone regeneration with potential applications in fractured bone regeneration.The excellent biocompatible and osteogenesis characteristics of porous scaffolds play a vital role in bone regeneration. In this study, we have synthesized polymeric hybrid nanocomposites via free-radical polymerization from carrageenan/acrylic-acid/graphene/hydroxyapatite. Porous hybrid nanocomposite scaffolds were fabricated through a freeze-drying method to mimic the structural and chemical composition of natural bone. Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and water contact-angle studies were carried-out for functional groups, surface morphology and hydrophilicity of the materials, followed by biodegradation and swelling analysis. The cell viability, cell culture and proliferation were evaluated against mouse pre-osteoblast (MC3T3-E1) cell lines using neutral red dye assay. The cell adherence and proliferation studies were determined by SEM. Physical characterization including optimum porosity and pore size (49.75% and 0.41 × 103 μm2), mechanical properties (compression strength 8.87 MPa and elastic modulus 442.63 MPa), swelling (70.20% at 27 °C and 77.21% at 37 °C) and biodegradation (23.8%) were performed. The results indicated CG-g-AAc-3 with a high optical density and better cell viability. Hence, CG-g-AAc-3 was found to be more efficient for bone regeneration with potential applications in fractured bone regeneration.
The excellent biocompatible and osteogenesis characteristics of porous scaffolds play a vital role in bone regeneration. In this study, we have synthesized polymeric hybrid nanocomposites via free-radical polymerization from carrageenan/acrylic-acid/graphene/hydroxyapatite. Porous hybrid nanocomposite scaffolds were fabricated through a freeze-drying method to mimic the structural and chemical composition of natural bone. Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and water contact-angle studies were carried-out for functional groups, surface morphology and hydrophilicity of the materials, followed by biodegradation and swelling analysis. The cell viability, cell culture and proliferation were evaluated against mouse pre-osteoblast (MC3T3-E1) cell lines using neutral red dye assay. The cell adherence and proliferation studies were determined by SEM. Physical characterization including optimum porosity and pore size (49.75% and 0.41 × 103 μm2), mechanical properties (compression strength 8.87 MPa and elastic modulus 442.63 MPa), swelling (70.20% at 27 °C and 77.21% at 37 °C) and biodegradation (23.8%) were performed. The results indicated CG-g-AAc-3 with a high optical density and better cell viability. Hence, CG-g-AAc-3 was found to be more efficient for bone regeneration with potential applications in fractured bone regeneration.
The excellent biocompatible and osteogenesis characteristics of porous scaffolds play a vital role in bone regeneration. In this study, we have synthesized polymeric hybrid nanocomposites via free-radical polymerization from carrageenan/acrylic-acid/graphene/hydroxyapatite. Porous hybrid nanocomposite scaffolds were fabricated through a freeze-drying method to mimic the structural and chemical composition of natural bone. Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and water contact-angle studies were carried-out for functional groups, surface morphology and hydrophilicity of the materials, followed by biodegradation and swelling analysis. The cell viability, cell culture and proliferation were evaluated against mouse pre-osteoblast (MC3T3-E1) cell lines using neutral red dye assay. The cell adherence and proliferation studies were determined by SEM. Physical characterization including optimum porosity and pore size (49.75% and 0.41 × 103 μm2), mechanical properties (compression strength 8.87 MPa and elastic modulus 442.63 MPa), swelling (70.20% at 27 °C and 77.21% at 37 °C) and biodegradation (23.8%) were performed. The results indicated CG-g-AAc-3 with a high optical density and better cell viability. Hence, CG-g-AAc-3 was found to be more efficient for bone regeneration with potential applications in fractured bone regeneration. The excellent biocompatible and osteogenesis characteristics of porous scaffolds play a vital role in bone regeneration.
The excellent biocompatible and osteogenesis characteristics of porous scaffolds play a vital role in bone regeneration. In this study, we have synthesized polymeric hybrid nanocomposites via free-radical polymerization from carrageenan/acrylic-acid/graphene/hydroxyapatite. Porous hybrid nanocomposite scaffolds were fabricated through a freeze-drying method to mimic the structural and chemical composition of natural bone. Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and water contact-angle studies were carried-out for functional groups, surface morphology and hydrophilicity of the materials, followed by biodegradation and swelling analysis. The cell viability, cell culture and proliferation were evaluated against mouse pre-osteoblast (MC3T3-E1) cell lines using neutral red dye assay. The cell adherence and proliferation studies were determined by SEM. Physical characterization including optimum porosity and pore size (49.75% and 0.41 × 10³ μm²), mechanical properties (compression strength 8.87 MPa and elastic modulus 442.63 MPa), swelling (70.20% at 27 °C and 77.21% at 37 °C) and biodegradation (23.8%) were performed. The results indicated CG-g-AAc-3 with a high optical density and better cell viability. Hence, CG-g-AAc-3 was found to be more efficient for bone regeneration with potential applications in fractured bone regeneration.
Author Iqbal, Muhammad Zahir
Abdul Kadir, Mohammed Rafiq
Abd Razak, Saiful Izwan
Amin, Rashid
Shah, Saqlain A.
Aslam Khan, Muhammad Umar
Raza, Mohsin Ali
Mehboob, Hassan
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  givenname: Muhammad Umar
  surname: Aslam Khan
  fullname: Aslam Khan, Muhammad Umar
  organization: Department of Polymer Engineering and Technology, University of the Punjab, 54590 Lahore, Pakistan, School of Biomedical Engineering and Health Sciences
– sequence: 2
  givenname: Mohsin Ali
  surname: Raza
  fullname: Raza, Mohsin Ali
  organization: Department of Metallurgy and Materials Engineering, CEET, University of the Punjab, Lahore, Pakistan
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  givenname: Hassan
  surname: Mehboob
  fullname: Mehboob, Hassan
  organization: Department of Engineering Management, College of Engineering, Prince Sultan University, Riyadh 11586, Saudi Arabia
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  givenname: Mohammed Rafiq
  surname: Abdul Kadir
  fullname: Abdul Kadir, Mohammed Rafiq
  organization: School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, 81300 Skudai, Malaysia
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  givenname: Saiful Izwan
  surname: Abd Razak
  fullname: Abd Razak, Saiful Izwan
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  givenname: Saqlain A.
  surname: Shah
  fullname: Shah, Saqlain A.
  organization: Materials Science Lab, Department of Physics, Forman Christian College (University), Lahore, Pakistan
– sequence: 7
  givenname: Muhammad Zahir
  surname: Iqbal
  fullname: Iqbal, Muhammad Zahir
  organization: Nanotechnology Research Laboratory, Faculty of Engineering Sciences, GIK Institute of Engineering Sciences and Technology, Pakistan
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  givenname: Rashid
  orcidid: 0000-0003-4627-7147
  surname: Amin
  fullname: Amin, Rashid
  organization: Department of Biology, College of Sciences, University of Hafr Al Batin, 39524 Hafar Al-batin, Saudi Arabia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35520852$$D View this record in MEDLINE/PubMed
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SSID ssj0000651261
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Snippet The excellent biocompatible and osteogenesis characteristics of porous scaffolds play a vital role in bone regeneration. In this study, we have synthesized...
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crossref
SourceType Open Access Repository
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StartPage 40529
SubjectTerms absorbance
Biocompatibility
Biodegradation
Biomedical materials
bone formation
bones
Carrageenan
Cell adhesion
cell culture
cell viability
Chemical composition
Chemistry
compression strength
Compressive strength
Contact angle
dyes
Fourier transform infrared spectroscopy
Fourier transforms
Free radical polymerization
freeze drying
Functional groups
Graphene
hydrophilicity
Hydroxyapatite
Mechanical properties
mice
Modulus of elasticity
Morphology
Nanocomposites
Optical density
polymerization
polymers
Pore size
Porosity
Regeneration (physiology)
Scaffolds
Scanning electron microscopy
Swelling
Tissue engineering
Title Development and in vitro evaluation of κ-carrageenan based polymeric hybrid nanocomposite scaffolds for bone tissue engineering
URI https://www.ncbi.nlm.nih.gov/pubmed/35520852
https://www.proquest.com/docview/2458733538
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https://pubmed.ncbi.nlm.nih.gov/PMC9057573
Volume 10
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