A Population Genomics Analysis of the Native Irish Galway Sheep Breed
The Galway sheep population is the only native Irish sheep breed and this livestock genetic resource is currently categorised as 'at-risk'. In the present study, comparative population genomics analyses of Galway sheep and other sheep populations of European origin were used to investigate...
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| Veröffentlicht in: | Frontiers in genetics Jg. 10; S. 927 |
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08.10.2019
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| Abstract | The Galway sheep population is the only native Irish sheep breed and this livestock genetic resource is currently categorised as 'at-risk'. In the present study, comparative population genomics analyses of Galway sheep and other sheep populations of European origin were used to investigate the microevolution and recent genetic history of the breed. These analyses support the hypothesis that British Leicester sheep were used in the formation of the Galway. When compared to conventional and endangered breeds, the Galway breed was intermediate in effective population size, genomic inbreeding and runs of homozygosity. This indicates that, although the Galway breed is declining, it is still relatively genetically diverse and that conservation and management plans informed by genomic information may aid its recovery. The Galway breed also exhibited distinct genomic signatures of artificial or natural selection when compared to other breeds, which highlighted candidate genes that may be involved in production and health traits.The Galway sheep population is the only native Irish sheep breed and this livestock genetic resource is currently categorised as 'at-risk'. In the present study, comparative population genomics analyses of Galway sheep and other sheep populations of European origin were used to investigate the microevolution and recent genetic history of the breed. These analyses support the hypothesis that British Leicester sheep were used in the formation of the Galway. When compared to conventional and endangered breeds, the Galway breed was intermediate in effective population size, genomic inbreeding and runs of homozygosity. This indicates that, although the Galway breed is declining, it is still relatively genetically diverse and that conservation and management plans informed by genomic information may aid its recovery. The Galway breed also exhibited distinct genomic signatures of artificial or natural selection when compared to other breeds, which highlighted candidate genes that may be involved in production and health traits. |
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| AbstractList | The Galway sheep population is the only native Irish sheep breed and this livestock genetic resource is currently categorised as 'at-risk'. In the present study, comparative population genomics analyses of Galway sheep and other sheep populations of European origin were used to investigate the microevolution and recent genetic history of the breed. These analyses support the hypothesis that British Leicester sheep were used in the formation of the Galway. When compared to conventional and endangered breeds, the Galway breed was intermediate in effective population size, genomic inbreeding and runs of homozygosity. This indicates that, although the Galway breed is declining, it is still relatively genetically diverse and that conservation and management plans informed by genomic information may aid its recovery. The Galway breed also exhibited distinct genomic signatures of artificial or natural selection when compared to other breeds, which highlighted candidate genes that may be involved in production and health traits.The Galway sheep population is the only native Irish sheep breed and this livestock genetic resource is currently categorised as 'at-risk'. In the present study, comparative population genomics analyses of Galway sheep and other sheep populations of European origin were used to investigate the microevolution and recent genetic history of the breed. These analyses support the hypothesis that British Leicester sheep were used in the formation of the Galway. When compared to conventional and endangered breeds, the Galway breed was intermediate in effective population size, genomic inbreeding and runs of homozygosity. This indicates that, although the Galway breed is declining, it is still relatively genetically diverse and that conservation and management plans informed by genomic information may aid its recovery. The Galway breed also exhibited distinct genomic signatures of artificial or natural selection when compared to other breeds, which highlighted candidate genes that may be involved in production and health traits. The Galway sheep population is the only native Irish sheep breed and this livestock genetic resource is currently categorised as ‘at-risk’. In the present study, comparative population genomics analyses of Galway sheep and other sheep populations of European origin were used to investigate the microevolution and recent genetic history of the breed. These analyses support the hypothesis that British Leicester sheep were used in the formation of the Galway. When compared to conventional and endangered breeds, the Galway breed was intermediate in effective population size, genomic inbreeding and runs of homozygosity. This indicates that, although the Galway breed is declining, it is still relatively genetically diverse and that conservation and management plans informed by genomic information may aid its recovery. The Galway breed also exhibited distinct genomic signatures of artificial or natural selection when compared to other breeds, which highlighted candidate genes that may be involved in production and health traits. |
| Author | MacHugh, David E. Park, Stephen D. E. Correia, Carolina N. Mullen, Michael P. Howard, Dawn J. Dover, Michael J. Scraggs, Erik Randhawa, Imtiaz A. S. McHugo, Gillian P. Richardson, Ian W. Magee, David A. Hanrahan, James P. Browett, Sam |
| AuthorAffiliation | 3 Animal and Grassland Research and Innovation Centre , Athenry , Ireland 2 Sydney School of Veterinary Science, University of Sydney , Camden, NSW , Australia 4 IdentiGEN Ltd., Blackrock Business Park , Dublin , Ireland 1 Animal Genomics Laboratory, UCD School of Agriculture and Food Science, University College Dublin , Dublin , Ireland 5 UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin , Dublin , Ireland |
| AuthorAffiliation_xml | – name: 4 IdentiGEN Ltd., Blackrock Business Park , Dublin , Ireland – name: 1 Animal Genomics Laboratory, UCD School of Agriculture and Food Science, University College Dublin , Dublin , Ireland – name: 5 UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin , Dublin , Ireland – name: 2 Sydney School of Veterinary Science, University of Sydney , Camden, NSW , Australia – name: 3 Animal and Grassland Research and Innovation Centre , Athenry , Ireland |
| Author_xml | – sequence: 1 givenname: Gillian P. surname: McHugo fullname: McHugo, Gillian P. – sequence: 2 givenname: Sam surname: Browett fullname: Browett, Sam – sequence: 3 givenname: Imtiaz A. S. surname: Randhawa fullname: Randhawa, Imtiaz A. S. – sequence: 4 givenname: Dawn J. surname: Howard fullname: Howard, Dawn J. – sequence: 5 givenname: Michael P. surname: Mullen fullname: Mullen, Michael P. – sequence: 6 givenname: Ian W. surname: Richardson fullname: Richardson, Ian W. – sequence: 7 givenname: Stephen D. E. surname: Park fullname: Park, Stephen D. E. – sequence: 8 givenname: David A. surname: Magee fullname: Magee, David A. – sequence: 9 givenname: Erik surname: Scraggs fullname: Scraggs, Erik – sequence: 10 givenname: Michael J. surname: Dover fullname: Dover, Michael J. – sequence: 11 givenname: Carolina N. surname: Correia fullname: Correia, Carolina N. – sequence: 12 givenname: James P. surname: Hanrahan fullname: Hanrahan, James P. – sequence: 13 givenname: David E. surname: MacHugh fullname: MacHugh, David E. |
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| Copyright | Copyright © 2019 McHugo, Browett, Randhawa, Howard, Mullen, Richardson, Park, Magee, Scraggs, Dover, Correia, Hanrahan and MacHugh. Copyright © 2019 McHugo, Browett, Randhawa, Howard, Mullen, Richardson, Park, Magee, Scraggs, Dover, Correia, Hanrahan and MacHugh 2019 McHugo, Browett, Randhawa, Howard, Mullen, Richardson, Park, Magee, Scraggs, Dover, Correia, Hanrahan and MacHugh |
| Copyright_xml | – notice: Copyright © 2019 McHugo, Browett, Randhawa, Howard, Mullen, Richardson, Park, Magee, Scraggs, Dover, Correia, Hanrahan and MacHugh. – notice: Copyright © 2019 McHugo, Browett, Randhawa, Howard, Mullen, Richardson, Park, Magee, Scraggs, Dover, Correia, Hanrahan and MacHugh 2019 McHugo, Browett, Randhawa, Howard, Mullen, Richardson, Park, Magee, Scraggs, Dover, Correia, Hanrahan and MacHugh |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Marco Tolone, University of Palermo, Italy; Emiliano Lasagna, University of Perugia, Italy This article was submitted to Livestock Genomics, a section of the journal Frontiers in Genetics Present address: Sam Browett, Ecosystems and Environment Research Centre, School of Environment and Life Sciences, University of Salford, Manchester, United Kingdom; Imtiaz A. S. Randhawa, School of Veterinary Science, University of Queensland, Gatton, QLD, Australia; Dawn J. Howard, Michael P. Mullen, Department of Life and Physical Sciences, Athlone Institute of Technology, Athlone, Co. Westmeath, Ireland; James P. Hanrahan, UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin, Ireland Edited by: Francesca Bertolini, Technical University of Denmark, Denmark |
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| Snippet | The Galway sheep population is the only native Irish sheep breed and this livestock genetic resource is currently categorised as 'at-risk'. In the present... The Galway sheep population is the only native Irish sheep breed and this livestock genetic resource is currently categorised as ‘at-risk’. In the present... |
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| SubjectTerms | at-risk breed conservation genomics genetic diversity Genetics inbreeding livestock selection signature |
| Title | A Population Genomics Analysis of the Native Irish Galway Sheep Breed |
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