Aerobic Exercise Training Improves Renal Injury in Spontaneously Hypertensive Rats by Increasing Renalase Expression in Medulla

We aimed to examine the effects of aerobic exercise training on renal function in spontaneously hypertensive rats (SHR) and elucidate their possible mechanisms. Adult male SHR and age-matched Wistar-Kyoto rats (WKY) were divided into four groups: WKY sedentary group, SHR sedentary group, low-intensi...

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Published in:Frontiers in cardiovascular medicine Vol. 9; p. 922705
Main Authors: Luo, Minghao, Cao, Shuyuan, Lv, Dingyi, He, Longlin, He, Zhou, Li, Lingang, Li, Yongjian, Luo, Suxin, Chang, Qing
Format: Journal Article
Language:English
Published: Frontiers Media S.A 11.07.2022
Subjects:
Cardiovascular Medicine
exercise
HK-2
kidney
renalase
SHR
ISSN:2297-055X, 2297-055X
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Summary:We aimed to examine the effects of aerobic exercise training on renal function in spontaneously hypertensive rats (SHR) and elucidate their possible mechanisms. Adult male SHR and age-matched Wistar-Kyoto rats (WKY) were divided into four groups: WKY sedentary group, SHR sedentary group, low-intensity training group, and medium-intensity training group. Using molecular and biochemical approaches, we investigated the effects of 14-week training on renalase (RNLS) protein levels, renal function, and apoptosis and oxidative stress modulators in kidney tissues. In vitro , angiotensin II (Ang II)-induced human kidney proximal epithelial cells (HK-2) were treated with RNLS, and changes in apoptosis and oxidative stress levels were observed. Our results show that moderate training improved renal function decline in SHR. In addition, aerobic exercise therapy significantly increased levels of RNLS in the renal medulla of SHR. We observed in vitro that RNLS significantly inhibited the increase of Ang II-inducedapoptosis and oxidative stress levels in HK-2. In conclusion, aerobic exercise training effectively improved renal function in SHR by promoting RNLS expression in the renal medulla. These results explain the possible mechanism in which exercise improves renal injury in hypertensive patients and suggest RNLS as a novel therapy for kidney injury patients.
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Reviewed by: Gary Desir, Yale University, United States; Ai-Lun Yang, University of Taipei, Taiwan
Edited by: David T. Paik, Stanford Cardiovascular Institute, United States
These authors have contributed equally to this work and share first authorship
This article was submitted to Cardiovascular Genetics and Systems Medicine, a section of the journal Frontiers in Cardiovascular Medicine
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2022.922705