A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and ‘At-Risk’ Individuals

A systematic review and meta-analysis was undertaken to examine and quantify the effects of B vitamin supplementation on mood in both healthy and ‘at-risk’ populations. A systematic search identified all available randomised controlled trials (RCTs) of daily supplementation with ≥3 B group vitamins...

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Vydáno v:	Nutrients Ročník 11; číslo 9; s. 2232
Hlavní autoři:	Young, Lauren M, Pipingas, Andrew, White, David J, Gauci, Sarah, Scholey, Andrew
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland MDPI AG 16.09.2019 MDPI
Témata:	Adolescent Adult Affect - drug effects Aged Aged, 80 and over Alzheimer's disease Anxiety Anxiety - diagnosis Anxiety - drug therapy Anxiety - epidemiology Anxiety - psychology at-risk population Biomarkers Brain research Clinical trials Depression - diagnosis Depression - drug therapy Depression - epidemiology Depression - psychology Diet Dietary Supplements - adverse effects DNA methylation Female Homocysteine Humans Intervention Male Mental depression Mental disorders Mental health Meta-analysis Middle Aged Neurotransmitters Nutrients Nutrition research Nutritional Status Older people Physiology placebos Prevention Psychopharmacology randomized clinical trials Randomized Controlled Trials as Topic Review risk Risk Assessment Risk Factors Stress Stress, Psychological - diagnosis Stress, Psychological - drug therapy Stress, Psychological - epidemiology Stress, Psychological - psychology Systematic review Treatment Outcome Vitamin B vitamin B complex Vitamin B Complex - adverse effects Vitamin B Complex - therapeutic use Vitamin B Deficiency - diagnosis Vitamin B Deficiency - drug therapy Vitamin B Deficiency - epidemiology Vitamin B Deficiency - psychology vitamin supplements Young Adult anxiety stress mood mental health review B-vitamins meta-analysis depression
ISSN:	2072-6643, 2072-6643
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Shrnutí:	A systematic review and meta-analysis was undertaken to examine and quantify the effects of B vitamin supplementation on mood in both healthy and ‘at-risk’ populations. A systematic search identified all available randomised controlled trials (RCTs) of daily supplementation with ≥3 B group vitamins with an intervention period of at least four weeks. Random effects models for a standardized mean difference were used to test for overall effect. Heterogeneity was tested using the I2 statistic. Eighteen articles (16 trials, 2015 participants) were included, of which 12 were eligible for meta-analysis. Eleven of the 18 articles reported a positive effect for B vitamins over a placebo for overall mood or a facet of mood. Of the eight studies in ‘at-risk’ cohorts, five found a significant benefit to mood. Regarding individual facets of mood, B vitamin supplementation benefited stress (n = 958, SMD = 0.23, 95% CI = 0.02, 0.45, p = 0.03). A benefit to depressive symptoms did not reach significance (n = 568, SMD = 0.15, 95% CI = −0.01, 0.32, p = 0.07), and there was no effect on anxiety (n = 562, SMD = 0.03, 95% CI = −0.13, 0.20, p = 0.71). The review provides evidence for the benefit of B vitamin supplementation in healthy and at-risk populations for stress, but not for depressive symptoms or anxiety. B vitamin supplementation may particularly benefit populations who are at risk due to (1) poor nutrient status or (2) poor mood status.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-3 ObjectType-Evidence Based Healthcare-1 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	2072-6643 2072-6643
DOI:	10.3390/nu11092232