Gold Nanoclusters for NIR‐II Fluorescence Imaging of Bones

Fluorescence imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) holds great promise for deep tissue visualization. Development of novel clinical translatable NIR‐II probes is crucial for realizing the medical applications of NIR‐II fluorescence imaging. Herein, the glutathione‐capped...

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Vydané v:Small (Weinheim an der Bergstrasse, Germany) Ročník 16; číslo 43; s. e2003851 - n/a
Hlavní autori: Li, Deling, Liu, Qiang, Qi, Qingrong, Shi, Hui, Hsu, En‐Chi, Chen, Weiyu, Yuan, Wenli, Wu, Yifan, Lin, Sien, Zeng, Yitian, Xiao, Zunyu, Xu, Lingyun, Zhang, Yanrong, Stoyanova, Tanya, Jia, Wang, Cheng, Zhen
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Germany Wiley Subscription Services, Inc 01.10.2020
Predmet:
Abnormalities
Bioaccumulation
bone targeting
Bones
Fluorescence
Glutathione
Gold
gold nanoclusters
Hydroxyapatite
Imaging
Infrared windows
Nanoclusters
Nanotechnology
NIR‐II imaging
Pedicle screws
renal excretable nanoparticles
Spleen
Surgical implants
Vertebrae
renal excretable nanoparticles
NIR-II imaging
bone targeting
gold nanoclusters
ISSN:1613-6810, 1613-6829, 1613-6829
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Shrnutí:Fluorescence imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) holds great promise for deep tissue visualization. Development of novel clinical translatable NIR‐II probes is crucial for realizing the medical applications of NIR‐II fluorescence imaging. Herein, the glutathione‐capped gold nanoclusters (AuNCs, specifically Au25(SG)18) demonstrate highly efficient binding capability to hydroxyapatite in vitro for the first time. Further in vivo NIR‐II fluorescence imaging of AuNCs indicate that they accumulate in bone tissues with high contrast and signal‐background ratio. AuNCs are also mainly and quickly excreted from body through renal system, showing excellent ribs and thoracic vertebra imaging because of no background signal in liver and spleen. The deep tissue penetration capability and high resolution of AuNCs in NIR‐II imaging render their great potential for fluorescence‐guided surgery like spinal pedicle screw implantation. Overall, AuNCs are highly promising and clinical translatable NIR‐II imaging probe for visualizing bone and bone related abnormalities. The glutathione‐capped gold nanoclusters, Au25(SG)18, demonstrate highly efficient binding capability to hydroxyapatite for the first time. They can be utilized for bone imaging with NIR‐II fluorescence with high contrast and can be excreted through renal system. The deep tissue penetration capability and high resolution render their great potential for clinical translation.
Bibliografia:ObjectType-Article-1
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ISSN:1613-6810
1613-6829
1613-6829
DOI:10.1002/smll.202003851