Variable NK cell receptors exemplified by human KIR3DL1/S1
Variegated expression of variable NK cell receptors for polymorphic MHC class I broadens the range of an individual's NK cell response and the capacity for populations and species to survive disease epidemics and population bottlenecks. On evolutionary time scales, this component of immunity is...
Saved in:
| Published in: | The Journal of immunology (1950) Vol. 187; no. 1; p. 11 |
|---|---|
| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
01.07.2011
|
| Subjects: | |
| ISSN: | 1550-6606, 1550-6606 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Variegated expression of variable NK cell receptors for polymorphic MHC class I broadens the range of an individual's NK cell response and the capacity for populations and species to survive disease epidemics and population bottlenecks. On evolutionary time scales, this component of immunity is exceptionally dynamic, unstable, and short-lived, being dependent on coevolution of ligands and receptors subject to varying, competing selection pressures. Consequently these systems of variable NK cell receptors are largely species specific and have recruited different classes of glycoprotein, even within the primate order of mammals. Such disparity helps to explain substantial differences in NK cell biology between humans and animal models, for which the population genetics is largely ignored. KIR3DL1/S1, which recognizes the Bw4 epitope of HLA-A and -B and is the most extensively studied of the variable NK cell receptors, exemplifies how variation in all possible parameters of function is recruited to diversify the human NK cell response. |
|---|---|
| AbstractList | Variegated expression of variable NK cell receptors for polymorphic MHC class I broadens the range of an individual's NK cell response and the capacity for populations and species to survive disease epidemics and population bottlenecks. On evolutionary time scales, this component of immunity is exceptionally dynamic, unstable, and short-lived, being dependent on coevolution of ligands and receptors subject to varying, competing selection pressures. Consequently these systems of variable NK cell receptors are largely species specific and have recruited different classes of glycoprotein, even within the primate order of mammals. Such disparity helps to explain substantial differences in NK cell biology between humans and animal models, for which the population genetics is largely ignored. KIR3DL1/S1, which recognizes the Bw4 epitope of HLA-A and -B and is the most extensively studied of the variable NK cell receptors, exemplifies how variation in all possible parameters of function is recruited to diversify the human NK cell response.Variegated expression of variable NK cell receptors for polymorphic MHC class I broadens the range of an individual's NK cell response and the capacity for populations and species to survive disease epidemics and population bottlenecks. On evolutionary time scales, this component of immunity is exceptionally dynamic, unstable, and short-lived, being dependent on coevolution of ligands and receptors subject to varying, competing selection pressures. Consequently these systems of variable NK cell receptors are largely species specific and have recruited different classes of glycoprotein, even within the primate order of mammals. Such disparity helps to explain substantial differences in NK cell biology between humans and animal models, for which the population genetics is largely ignored. KIR3DL1/S1, which recognizes the Bw4 epitope of HLA-A and -B and is the most extensively studied of the variable NK cell receptors, exemplifies how variation in all possible parameters of function is recruited to diversify the human NK cell response. Variegated expression of variable NK cell receptors for polymorphic MHC class I broadens the range of an individual's NK cell response and the capacity for populations and species to survive disease epidemics and population bottlenecks. On evolutionary time scales, this component of immunity is exceptionally dynamic, unstable, and short-lived, being dependent on coevolution of ligands and receptors subject to varying, competing selection pressures. Consequently these systems of variable NK cell receptors are largely species specific and have recruited different classes of glycoprotein, even within the primate order of mammals. Such disparity helps to explain substantial differences in NK cell biology between humans and animal models, for which the population genetics is largely ignored. KIR3DL1/S1, which recognizes the Bw4 epitope of HLA-A and -B and is the most extensively studied of the variable NK cell receptors, exemplifies how variation in all possible parameters of function is recruited to diversify the human NK cell response. |
| Author | Norman, Paul J Abi-Rached, Laurent Parham, Peter Guethlein, Lisbeth A |
| Author_xml | – sequence: 1 givenname: Peter surname: Parham fullname: Parham, Peter organization: Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA – sequence: 2 givenname: Paul J surname: Norman fullname: Norman, Paul J – sequence: 3 givenname: Laurent surname: Abi-Rached fullname: Abi-Rached, Laurent – sequence: 4 givenname: Lisbeth A surname: Guethlein fullname: Guethlein, Lisbeth A |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21690332$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNj0tLw0AUhQep2IfuXcnsXKW980zGndRXaVDwtQ2TyQ2mZJKYacD-eytWcHXO4uPjnCkZNW2DhJwzmEuQZrGpvB-atp6DAS4EPyITphREWoMe_etjMg1hAwAauDwhY860gT0_IVfvtq9sXiN9XFOHdU17dNht2z5Q_ELf1VVZYUHzHf0YvG3oevUsblK2eGGn5Li0dcCzQ87I293t6_IhSp_uV8vrNHJSJNuoLJgBG2OORiuHDArICyXBGaOSXCel5o5xrbRxzEoRQ8G5iXnuCiGkdpLPyOWvt-vbzwHDNvNV-JlqG2yHkCWxEEwlKt6TFwdyyD0WWddX3va77O8u_wYljVeH |
| CitedBy_id | crossref_primary_10_1016_j_jtct_2024_02_014 crossref_primary_10_1155_2013_283805 crossref_primary_10_1371_journal_pone_0099543 crossref_primary_10_1016_j_clim_2016_11_010 crossref_primary_10_1200_JCO_2015_64_9558 crossref_primary_10_1097_QAD_0000000000001735 crossref_primary_10_3390_v11100959 crossref_primary_10_1016_j_bbmt_2011_10_033 crossref_primary_10_1097_COH_0b013e3283522b56 crossref_primary_10_1053_j_gastro_2018_07_019 crossref_primary_10_3389_fimmu_2017_01496 crossref_primary_10_1038_gene_2013_55 crossref_primary_10_3390_cancers13153767 crossref_primary_10_1038_ni_3513 crossref_primary_10_1007_s00262_016_1806_9 crossref_primary_10_3389_fimmu_2021_798235 crossref_primary_10_1186_1479_5876_11_262 crossref_primary_10_1097_MOT_0000000000000103 crossref_primary_10_1111_imr_12329 crossref_primary_10_1007_s00251_013_0724_7 crossref_primary_10_1016_j_it_2017_12_001 crossref_primary_10_3389_fimmu_2019_00024 crossref_primary_10_1111_tan_15251 crossref_primary_10_1016_j_vetimm_2012_09_022 crossref_primary_10_1016_j_placenta_2011_11_020 crossref_primary_10_1016_j_coi_2017_11_003 crossref_primary_10_1016_j_autrev_2012_10_007 crossref_primary_10_1016_j_humimm_2018_10_003 crossref_primary_10_3389_fimmu_2017_00547 crossref_primary_10_1111_cbdd_13658 crossref_primary_10_1155_2015_427217 crossref_primary_10_1016_j_cell_2024_10_005 crossref_primary_10_1371_journal_pone_0225151 crossref_primary_10_3389_fimmu_2017_00581 crossref_primary_10_4049_jimmunol_1201360 crossref_primary_10_1038_s41598_022_21062_1 crossref_primary_10_1158_1078_0432_CCR_18_3041 crossref_primary_10_1371_journal_pcbi_1009059 crossref_primary_10_1371_journal_pone_0064736 crossref_primary_10_1016_j_humimm_2022_07_006 crossref_primary_10_1038_s41409_018_0218_1 crossref_primary_10_1371_journal_pgen_1003938 crossref_primary_10_3389_fimmu_2014_00184 crossref_primary_10_1200_JCO_2016_70_7059 crossref_primary_10_3389_fimmu_2015_00134 crossref_primary_10_4049_jimmunol_1500243 crossref_primary_10_1016_j_humimm_2017_10_008 crossref_primary_10_1371_journal_pone_0163297 crossref_primary_10_1002_eji_201243007 crossref_primary_10_4049_jimmunol_1801178 crossref_primary_10_1111_tan_14782 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.4049/jimmunol.0902332 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1550-6606 |
| ExternalDocumentID | 21690332 |
| Genre | Comparative Study Review Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIAID NIH HHS grantid: R01 AI017892 – fundername: NIAID NIH HHS grantid: AI024258 – fundername: NIAID NIH HHS grantid: AI017892 – fundername: NIAID NIH HHS grantid: R01 AI031168 – fundername: NIAID NIH HHS grantid: AI022039 – fundername: NIAID NIH HHS grantid: AI031168 |
| GroupedDBID | --- -~X .55 0R~ 18M 1KJ 2WC 34G 39C 3O- 53G 5GY 5RE 5VS 5WD 79B 85S AARDX ABCQX ABDFA ABEJV ABGNP ABJNI ABOCM ABPPZ ABXVV ACGFO ACGFS ACIWK ACNCT ACPRK ADBBV ADIPN ADNWM AENEX AETEA AFFNX AFHIN AFOSN AFRAH AGORE AHMMS AHWXS AIZAD ALMA_UNASSIGNED_HOLDINGS ARBBW BAWUL BCRHZ BTFSW CGR CUY CVF D0L DIK DU5 E3Z EBS ECM EIF EJD F5P GX1 H13 IH2 K-O KQ8 L7B NPM OCZFY OK1 OWPYF P0W P2P PQQKQ R.V RHI ROX RZQ SJN TR2 TWZ W8F WH7 WOQ X7M XJT XSW XTH YHG 7X8 KOP |
| ID | FETCH-LOGICAL-c438t-fd190a7ebe965ce10d0bd540c9958b68f62c126569c1a4370d22972bcd3346c42 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 53 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000291799300005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1550-6606 |
| IngestDate | Wed Oct 01 13:33:48 EDT 2025 Mon Jul 21 05:43:55 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c438t-fd190a7ebe965ce10d0bd540c9958b68f62c126569c1a4370d22972bcd3346c42 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://www.jimmunol.org/content/jimmunol/187/1/11.full.pdf |
| PMID | 21690332 |
| PQID | 873315857 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_873315857 pubmed_primary_21690332 |
| PublicationCentury | 2000 |
| PublicationDate | 2011-Jul-01 20110701 |
| PublicationDateYYYYMMDD | 2011-07-01 |
| PublicationDate_xml | – month: 07 year: 2011 text: 2011-Jul-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | The Journal of immunology (1950) |
| PublicationTitleAlternate | J Immunol |
| PublicationYear | 2011 |
| SSID | ssj0006024 |
| Score | 2.2757187 |
| SecondaryResourceType | review_article |
| Snippet | Variegated expression of variable NK cell receptors for polymorphic MHC class I broadens the range of an individual's NK cell response and the capacity for... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 11 |
| SubjectTerms | Alleles Animals Disease Models, Animal Evolution, Molecular Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class I - metabolism HLA-B Antigens - genetics HLA-B Antigens - immunology HLA-B Antigens - metabolism Humans Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Peptide Fragments - immunology Peptide Fragments - metabolism Phylogeny Receptors, KIR3DL1 - genetics Receptors, KIR3DL1 - immunology Receptors, KIR3DL1 - metabolism Receptors, KIR3DS1 - genetics Receptors, KIR3DS1 - immunology Receptors, KIR3DS1 - metabolism |
| Title | Variable NK cell receptors exemplified by human KIR3DL1/S1 |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/21690332 https://www.proquest.com/docview/873315857 |
| Volume | 187 |
| WOSCitedRecordID | wos000291799300005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3JTsMwEB0BBcSFfSmbfOBqmtiuk3BBCKhAbaOKTb1V8RKpCCWFFkT_nnGSwglx4JJTIlnj8fhl5s08gBNljfJSv0kjKxMqrJFUIcqmPnqTVcYakxZzZjtBHIf9ftSruDnjilY5i4lFoDa5djnyRujEBRHbBuejV-pEo1xxtVLQmIcaRyTjnDro_wwLl16paYsgnEoE6mWVUiAmbjwPXfdF_nLqaIncaY_8hi-Le6a19s8VrsNqBTDJRekRGzBns01YKiUnp5uw3K2K6Vtw9oT_ya5zisRt4hL4BKOfHTn5HWI_raOapwhQiZqSQsmPtG_v-FXHb9z72_DYun64vKGVlALVgocTmhq8-JMAdyySTW19z3jKIFjTUdQMlQxTybTPENtF2k8EDzzDWBQwpQ3nQmrBdmAhyzO7B4QLFSh8L_GkEVzKRKSe6-ZNhWEJxtY6kJl5BuiqbvlJZvP38eDbQHXYLU08GJUjNQbMVetwH_b__vgAVsq8rqPMHkItxWNqj2BRf0yG47fjwgXwGfe6X92ouag |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Variable+NK+cell+receptors+exemplified+by+human+KIR3DL1%2FS1&rft.jtitle=The+Journal+of+immunology+%281950%29&rft.au=Parham%2C+Peter&rft.au=Norman%2C+Paul+J&rft.au=Abi-Rached%2C+Laurent&rft.au=Guethlein%2C+Lisbeth+A&rft.date=2011-07-01&rft.eissn=1550-6606&rft.volume=187&rft.issue=1&rft.spage=11&rft_id=info:doi/10.4049%2Fjimmunol.0902332&rft_id=info%3Apmid%2F21690332&rft_id=info%3Apmid%2F21690332&rft.externalDocID=21690332 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1550-6606&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1550-6606&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1550-6606&client=summon |