Utilization of quercetin and quercetin glycosides from onion (Allium cepa L.) solid waste as an antioxidant, urease and xanthine oxidase inhibitors

[Display omitted] •Onion solid waste (OSW) used as cheap and valuable source for production of value-added products.•HPLC revealed significant amount of quercetin and quercetin glycosides in OSW.•OSW extracts inhibited the urease and xanthine oxidase activity in vitro.•OSW showed potent antioxidant...

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Veröffentlicht in:Food chemistry Jg. 235; S. 119 - 126
Hauptverfasser: Nile, Shivraj Hariram, Nile, Arti Shivraj, Keum, Young Soo, Sharma, Kavita
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Ltd 15.11.2017
Schlagworte:
Allium cepa
allopurinol
antioxidant activity
Antioxidants
chloroform
enzyme inhibition
ethanol
ethyl acetate
Glycosides
hexane
high performance liquid chromatography
HPLC
inhibitory concentration 50
methanol
Onion
onions
Onions - chemistry
Plant Extracts
quercetin
Quercetin - analysis
Solid Waste
solid wastes
thiourea
Urease
Urease - analysis
Urease - antagonists & inhibitors
Xanthine oxidase
Xanthine Oxidase - analysis
Xanthine Oxidase - antagonists & inhibitors
Onion
Urease
Antioxidants
Quercetin (PubChem CID: 5280343)
Solid waste
Quercetin 3, 4′-O-diglucoside (PubChem CID: 5320835)
Xanthine oxidase
Allopurinol (PubChem CID: 2094)
Ferric chloride (PubChem CID: 24380)
Gallic acid (PubChem CID: 370)
Quercetin 4′-O-glucoside (PubChem CID: 54758556)
Thiourea (PubChem CID: 2723790)
Trichloroacetic acid (PubChem CID: 6421)
HPLC
Isorhamnetin-3-glucoside (PubChem CID: 5318645)
Xanthine (PubChem CID: 1188)
ISSN:0308-8146, 1873-7072, 1873-7072
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Zusammenfassung:[Display omitted] •Onion solid waste (OSW) used as cheap and valuable source for production of value-added products.•HPLC revealed significant amount of quercetin and quercetin glycosides in OSW.•OSW extracts inhibited the urease and xanthine oxidase activity in vitro.•OSW showed potent antioxidant activity with in vitro scavenging assays. This study aimed to determine the flavonol glycosides from onion solid waste (OSW) using HPLC analysis, with antioxidant and enzyme inhibitory activities. We found considerable amount of quercetin-4′-O-monoglucoside (QMG: 254.85), quercetin-3,4′-O-diglucoside (QDG: 162.34), quercetin (Q: 60.44), and isorhamnetin-3-glucoside (IMG: 23.92) (mg/100g) dry weight (DW) of OSW. For OSW, the methanol and ethanol showed the strongest antioxidant activities, followed by ethyl acetate, chloroform, and n-hexane extracts. Among the flavonols, Q and QDG possessed higher antioxidant activities. OSW and flavonol glycosides displayed significant enzyme inhibitory activity, with IC50 values ranging from 12.5±0.11 to 32.5±0.28 for OSW, 8.2±0.07 to 16.8±0.02 for flavonol glycosides, and 4.2±0.05μg/mL for thiourea (positive control) towards urease; while 15.2±0.8 to 35.8±0.2 (μg/mL) for OSW, 10.5±0.06 to 20.8±0.05 (μg/mL) for flavonol glycosides, and 6.5±0.05μg/mL for allopurinol (positive control) towards xanthine oxidase, respectively. The OSW and flavonol glycosides may thus be considered as potential antioxidant and antigout agents.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0308-8146
1873-7072
1873-7072
DOI:10.1016/j.foodchem.2017.05.043