Exercise facilitates post-stroke recovery through mitigation of neuronal hyperexcitability via interleukin-10 signaling

Physical exercise is an effective therapy for improving stroke recovery. However, the exact underlying molecular mechanisms of exercise-enhanced neuronal repair remain unclear. As exercise affects the immune system in healthy individuals, and the immune system in turn influences recovery after strok...

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Vydané v:	Nature communications Ročník 16; číslo 1; s. 8928 - 16
Hlavní autori:	Schmidt-Pogoda, A., Ruck, T., Strecker, JK, Hoppen, M., Fazio, L., Vinnenberg, L., Maus, B., Wachsmuth, L., Cerina, M., Diederich, K., Lichtenberg, S., Abberger, H., Haertel, LAL, Schafflick, D., Meyer zu Hörste, G., Herrmann, AM, Hundehege, P., Narayanan, V., Nelke, C., Kruithoff, K., Bosbach, J., Vicari, E., Ramcke, T., Beuker, C., Hadaschik, E., Budde, T., Faber, C., Wiendl, H., Hansen, W., Meuth, SG, Minnerup, J.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 08.10.2025 Nature Publishing Group Nature Portfolio
Predmet:	13/1 13/106 13/31 13/51 14/19 14/34 14/35 14/63 38/77 59 59/57 64/110 692/617/375/380 692/617/375/534 Adhesives Animals Asymmetry Brain - pathology Brain - physiopathology Brain Ischemia - immunology Brain Ischemia - physiopathology Cytokines Disease Models, Animal Exercise Humanities and Social Sciences Immune system Immunoregulation Interleukin 10 Interleukin-10 - genetics Interleukin-10 - metabolism Interleukins Ischemia Ischemic Stroke - immunology Ischemic Stroke - physiopathology Lymphocytes Lymphocytes T Magnetic resonance imaging Male Mice Mice, Inbred C57BL Molecular modelling multidisciplinary Neural networks Neurons - metabolism Neurons - physiology Neuroplasticity Physical Conditioning, Animal - physiology Physical exercise Recovery Recovery of Function Regeneration Science Science (multidisciplinary) Signal Transduction Stroke Stroke - immunology Stroke - physiopathology Stroke Rehabilitation - methods Structure-function relationships T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism
ISSN:	2041-1723, 2041-1723
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Shrnutí:	Physical exercise is an effective therapy for improving stroke recovery. However, the exact underlying molecular mechanisms of exercise-enhanced neuronal repair remain unclear. As exercise affects the immune system in healthy individuals, and the immune system in turn influences recovery after stroke, we hypothesized that immune mechanisms play a role in exercise-induced neurological recovery. Using a model of ischemic stroke in adult male mice, we here show that the presence of regulatory T cells (Treg) within the ischemic brain is a prerequisite for exercise-enhanced functional and structural recovery. Treg prevent excessive and sustained hyperexcitability of periinfarct neurons via IL-10 signaling. This reduced hyperexcitability precedes alterations in neuronal connectivity, which underlie functional improvement. Together, we delineate the interaction of exercise-therapy, the immune system and functional recovery after ischemic stroke. Our findings can have translational relevance for further development of immune-targeted therapies. Exercise promotes recovery after stroke, but the underlying mechanisms are unclear. Here, the authors show that regulatory T cells enable exercise-induced repair by reducing neuronal hyperexcitability via interleukin-10, linking immunity to functional regeneration.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-025-62631-y