Nitric Oxide Inhibits Hetero-adhesion of Cancer Cells to Endothelial Cells: Restraining Circulating Tumor Cells from Initiating Metastatic Cascade

Adhesion of circulating tumor cells (CTCs) to vascular endothelial bed becomes a crucial starting point in metastatic cascade. We hypothesized that nitric oxide (NO) may prevent cancer metastasis from happening by its direct vasodilation and inhibition of cell adhesion molecules (CAMs). Here we show...

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Bibliographic Details
Published in:	Scientific reports Vol. 4; no. 1; p. 4344
Main Authors:	Lu, Yusheng, Yu, Ting, Liang, Haiyan, Wang, Jichuang, Xie, Jingjing, Shao, Jingwei, Gao, Yu, Yu, Suhong, Chen, Shuming, Wang, Lie, Jia, Lee
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 11.03.2014 Nature Publishing Group
Subjects:	13/106 13/21 13/31 13/95 14/1 14/34 14/63 631/154/436 631/337 631/67/2195 631/80/79 82/29 82/80 Adhesion Cancer Captopril - analogs & derivatives Captopril - chemistry Captopril - pharmacology Cell adhesion & migration Cell Adhesion - drug effects Cell adhesion molecules Cell cycle Cell Cycle - drug effects Cell Line, Tumor Cell Survival - drug effects Colorectal carcinoma Cytokines Cytokines - pharmacology Cytotoxicity Endothelial cells Endothelium Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Enzyme Inhibitors - pharmacology Gene Expression - drug effects Guanylate cyclase Guanylate Cyclase - antagonists & inhibitors Guanylate Cyclase - metabolism Hemoglobin Hemoglobins - pharmacology Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - drug effects Humanities and Social Sciences Humans Membrane potential Metastases Metastasis Mitochondria multidisciplinary Neoplasm Metastasis - prevention & control Neoplastic Cells, Circulating - drug effects Neoplastic Cells, Circulating - pathology Nitric oxide Nitric Oxide - antagonists & inhibitors Nitric Oxide - chemistry Nitric Oxide - pharmacology Nitric Oxide Donors - chemistry Nitric Oxide Donors - pharmacology Science Tumor cells Umbilical vein Vascular cell adhesion molecule 1 Vascular Cell Adhesion Molecule-1 - genetics Vascular Cell Adhesion Molecule-1 - metabolism Vasodilation Vasodilation - drug effects
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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