Comparative assessment of phytochemical profiles, antioxidant and antiproliferative activities of Sea buckthorn (Hippophaë rhamnoides L.) berries

•Evaluated the phytochemical composition in four Sea buckthorn subspecies.•Compared in vitro and cellular antioxidant activities of phytochemical extracts.•Analyzed antiproliferative activity of phytochemical extracts and components.•Correlated of main effective composition with bioactive activities...

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Vydáno v:	Food chemistry Ročník 221; s. 997 - 1003
Hlavní autoři:	Guo, Ruixue, Guo, Xinbo, Li, Tong, Fu, Xiong, Liu, Rui Hai
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Elsevier Ltd 15.04.2017
Témata:	Antioxidant activity antioxidants Antioxidants - analysis Antiproliferative activity Chromatography, High Pressure Liquid Flavonoids - analysis Fruit - chemistry Hippophae - chemistry Hippophae rhamnoides human cell lines isorhamnetin kaempferol liver neoplasms median effective concentration phenolic acids Phenolics Phenols - analysis Phytochemicals Phytochemicals - analysis phytopharmaceuticals Plant Extracts - chemistry quercetin Quercetin - analogs & derivatives Quercetin - analysis Sea buckthorn small fruits Phytochemicals Antiproliferative activity Sea buckthorn Phenolics Antioxidant activity
ISSN:	0308-8146, 1873-7072
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Abstract	•Evaluated the phytochemical composition in four Sea buckthorn subspecies.•Compared in vitro and cellular antioxidant activities of phytochemical extracts.•Analyzed antiproliferative activity of phytochemical extracts and components.•Correlated of main effective composition with bioactive activities in Sea buckthorn. Phytochemical profiles, antioxidant and antiproliferative activities of berry extracts were evaluated and compared in four subspecies of Sea buckthorn (Hippophaë rhamnoides L.). Among the subspecies, Hippophaë rhamnoides L. subsp. sinensis exhibited highest total phenolics content (38.7±1.3mgGA equiv./g DW) and corresponding total antioxidant activity. Whereas maximum cellular antioxidant and antiproliferative activities were determined in Hippophaë rhamnoides L. subsp. yunnanensis. Total antioxidant activity was significantly associated to total phenolics, isorhamnetin-3-rutinoside and isorhamnetin-3-glucoside. The cellular antioxidant activity and antiproliferative activity of phytochemicals were fairly correlated to phenolic acids and flavonoid aglycones. Lower median effective dose (EC50) of individual compounds against human liver cancer HepG2 cells proliferation studies confirmed the better correlation between antiproliferative activity of Sea buckthorn extracts and flavonoid aglycones, including isorhamnetin, quercetin and kaempferol.
AbstractList	Phytochemical profiles, antioxidant and antiproliferative activities of berry extracts were evaluated and compared in four subspecies of Sea buckthorn (Hippophaë rhamnoides L.). Among the subspecies, Hippophaë rhamnoides L. subsp. sinensis exhibited highest total phenolics content (38.7±1.3mgGA equiv./g DW) and corresponding total antioxidant activity. Whereas maximum cellular antioxidant and antiproliferative activities were determined in Hippophaë rhamnoides L. subsp. yunnanensis. Total antioxidant activity was significantly associated to total phenolics, isorhamnetin-3-rutinoside and isorhamnetin-3-glucoside. The cellular antioxidant activity and antiproliferative activity of phytochemicals were fairly correlated to phenolic acids and flavonoid aglycones. Lower median effective dose (EC50) of individual compounds against human liver cancer HepG2 cells proliferation studies confirmed the better correlation between antiproliferative activity of Sea buckthorn extracts and flavonoid aglycones, including isorhamnetin, quercetin and kaempferol. Phytochemical profiles, antioxidant and antiproliferative activities of berry extracts were evaluated and compared in four subspecies of Sea buckthorn (Hippophaë rhamnoides L.). Among the subspecies, Hippophaë rhamnoides L. subsp. sinensis exhibited highest total phenolics content (38.7±1.3mgGA equiv./g DW) and corresponding total antioxidant activity. Whereas maximum cellular antioxidant and antiproliferative activities were determined in Hippophaë rhamnoides L. subsp. yunnanensis. Total antioxidant activity was significantly associated to total phenolics, isorhamnetin-3-rutinoside and isorhamnetin-3-glucoside. The cellular antioxidant activity and antiproliferative activity of phytochemicals were fairly correlated to phenolic acids and flavonoid aglycones. Lower median effective dose (EC ) of individual compounds against human liver cancer HepG2 cells proliferation studies confirmed the better correlation between antiproliferative activity of Sea buckthorn extracts and flavonoid aglycones, including isorhamnetin, quercetin and kaempferol. •Evaluated the phytochemical composition in four Sea buckthorn subspecies.•Compared in vitro and cellular antioxidant activities of phytochemical extracts.•Analyzed antiproliferative activity of phytochemical extracts and components.•Correlated of main effective composition with bioactive activities in Sea buckthorn. Phytochemical profiles, antioxidant and antiproliferative activities of berry extracts were evaluated and compared in four subspecies of Sea buckthorn (Hippophaë rhamnoides L.). Among the subspecies, Hippophaë rhamnoides L. subsp. sinensis exhibited highest total phenolics content (38.7±1.3mgGA equiv./g DW) and corresponding total antioxidant activity. Whereas maximum cellular antioxidant and antiproliferative activities were determined in Hippophaë rhamnoides L. subsp. yunnanensis. Total antioxidant activity was significantly associated to total phenolics, isorhamnetin-3-rutinoside and isorhamnetin-3-glucoside. The cellular antioxidant activity and antiproliferative activity of phytochemicals were fairly correlated to phenolic acids and flavonoid aglycones. Lower median effective dose (EC50) of individual compounds against human liver cancer HepG2 cells proliferation studies confirmed the better correlation between antiproliferative activity of Sea buckthorn extracts and flavonoid aglycones, including isorhamnetin, quercetin and kaempferol.
Author	Guo, Ruixue Li, Tong Fu, Xiong Guo, Xinbo Liu, Rui Hai
Author_xml	– sequence: 1 givenname: Ruixue surname: Guo fullname: Guo, Ruixue organization: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China – sequence: 2 givenname: Xinbo surname: Guo fullname: Guo, Xinbo email: xbg720@gmail.com organization: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China – sequence: 3 givenname: Tong surname: Li fullname: Li, Tong organization: Department of Food Science, Cornell University, Ithaca, NY 14853, United States – sequence: 4 givenname: Xiong surname: Fu fullname: Fu, Xiong organization: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China – sequence: 5 givenname: Rui Hai surname: Liu fullname: Liu, Rui Hai email: rl23@cornell.edu organization: Department of Food Science, Cornell University, Ithaca, NY 14853, United States
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Keywords	Phytochemicals Antiproliferative activity Sea buckthorn Phenolics Antioxidant activity
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Snippet	•Evaluated the phytochemical composition in four Sea buckthorn subspecies.•Compared in vitro and cellular antioxidant activities of phytochemical... Phytochemical profiles, antioxidant and antiproliferative activities of berry extracts were evaluated and compared in four subspecies of Sea buckthorn...
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SubjectTerms	Antioxidant activity antioxidants Antioxidants - analysis Antiproliferative activity Chromatography, High Pressure Liquid Flavonoids - analysis Fruit - chemistry Hippophae - chemistry Hippophae rhamnoides human cell lines isorhamnetin kaempferol liver neoplasms median effective concentration phenolic acids Phenolics Phenols - analysis Phytochemicals Phytochemicals - analysis phytopharmaceuticals Plant Extracts - chemistry quercetin Quercetin - analogs & derivatives Quercetin - analysis Sea buckthorn small fruits
Title	Comparative assessment of phytochemical profiles, antioxidant and antiproliferative activities of Sea buckthorn (Hippophaë rhamnoides L.) berries
URI	https://dx.doi.org/10.1016/j.foodchem.2016.11.063 https://www.ncbi.nlm.nih.gov/pubmed/27979305 https://www.proquest.com/docview/1852684103 https://www.proquest.com/docview/2131884036
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