Comparative assessment of phytochemical profiles, antioxidant and antiproliferative activities of Sea buckthorn (Hippophaë rhamnoides L.) berries

•Evaluated the phytochemical composition in four Sea buckthorn subspecies.•Compared in vitro and cellular antioxidant activities of phytochemical extracts.•Analyzed antiproliferative activity of phytochemical extracts and components.•Correlated of main effective composition with bioactive activities...

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Vydáno v:Food chemistry Ročník 221; s. 997 - 1003
Hlavní autoři: Guo, Ruixue, Guo, Xinbo, Li, Tong, Fu, Xiong, Liu, Rui Hai
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 15.04.2017
Témata:
Antioxidant activity
antioxidants
Antioxidants - analysis
Antiproliferative activity
Chromatography, High Pressure Liquid
Flavonoids - analysis
Fruit - chemistry
Hippophae - chemistry
Hippophae rhamnoides
human cell lines
isorhamnetin
kaempferol
liver neoplasms
median effective concentration
phenolic acids
Phenolics
Phenols - analysis
Phytochemicals
Phytochemicals - analysis
phytopharmaceuticals
Plant Extracts - chemistry
quercetin
Quercetin - analogs & derivatives
Quercetin - analysis
Sea buckthorn
small fruits
Phytochemicals
Antiproliferative activity
Sea buckthorn
Phenolics
Antioxidant activity
ISSN:0308-8146, 1873-7072
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Shrnutí:•Evaluated the phytochemical composition in four Sea buckthorn subspecies.•Compared in vitro and cellular antioxidant activities of phytochemical extracts.•Analyzed antiproliferative activity of phytochemical extracts and components.•Correlated of main effective composition with bioactive activities in Sea buckthorn. Phytochemical profiles, antioxidant and antiproliferative activities of berry extracts were evaluated and compared in four subspecies of Sea buckthorn (Hippophaë rhamnoides L.). Among the subspecies, Hippophaë rhamnoides L. subsp. sinensis exhibited highest total phenolics content (38.7±1.3mgGA equiv./g DW) and corresponding total antioxidant activity. Whereas maximum cellular antioxidant and antiproliferative activities were determined in Hippophaë rhamnoides L. subsp. yunnanensis. Total antioxidant activity was significantly associated to total phenolics, isorhamnetin-3-rutinoside and isorhamnetin-3-glucoside. The cellular antioxidant activity and antiproliferative activity of phytochemicals were fairly correlated to phenolic acids and flavonoid aglycones. Lower median effective dose (EC50) of individual compounds against human liver cancer HepG2 cells proliferation studies confirmed the better correlation between antiproliferative activity of Sea buckthorn extracts and flavonoid aglycones, including isorhamnetin, quercetin and kaempferol.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2016.11.063