IGF-1 regulates cancer cell immune evasion in prostate cancer

Insulin-like growth factor-1 (IGF-1) is associated with prostate cancer (PCa) development and lethality and exhibits immunosuppressive properties in other models. We investigated IGF-1’s tumor-intrinsic immune effects in PCa to understand mechanisms underlying its poor immunotherapy response. Transc...

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Bibliographic Details
Published in:	Scientific reports Vol. 15; no. 1; pp. 38422 - 10
Main Authors:	Nandakumar, Ashwin M., Barberis, Alessandro, Kim, Jinseon, Lang, Cameron R., Mills, Jack V., Rieunier, Guillaume, Doultsinos, Dimitrios, Taylor, Avigail, Jainarayanan, Ashwin, Phyu, Su M., Campo, Leticia, Easton, Alistair, Parkes, Eileen E., James, Timothy, Hamdy, Freddie C., Verrill, Clare, Mills, Ian G., Macaulay, Valentine M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 03.11.2025 Nature Publishing Group Nature Portfolio
Subjects:	631/67 631/67/580 AKT protein Aminopeptidase Androgens Animals Antigen Presentation Antigen processing Autophagy B7-H1 Antigen - genetics B7-H1 Antigen - metabolism Cell cycle Cell Line, Tumor Cell recognition Cytokines Down-regulation Endoplasmic reticulum Gene Expression Regulation, Neoplastic Genes Humanities and Social Sciences Humans Immune checkpoint Immune Evasion Immune response Immunofluorescence Immunotherapy Insulin-like growth factor I Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - immunology Insulin-Like Growth Factor I - metabolism Insulin-like growth factor-binding protein 5 Insulin-like growth factors Lethality Lupus Male Metastasis Mice multidisciplinary Myc protein PD-L1 protein Peptides Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - immunology Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proteins Science Science (multidisciplinary) Signal processing Signal Transduction Tumor Escape β2 Microglobulin
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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