Telomere maintenance and DNA damage responses during lung carcinogenesis

Telomere shortening is an early event in bronchial carcinogenesis, preceding P53/Rb pathway inactivation and telomerase reactivation, and leading to DNA damage responses (DDR). As their inactivation in cancer increases genetic instability, our objective was to identify the chronology of telomere mac...

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Bibliographic Details
Published in:	Clinical cancer research Vol. 16; no. 11; p. 2979
Main Authors:	Lantuejoul, Sylvie, Raynaud, Christophe, Salameire, Dimitri, Gazzeri, Sylvie, Moro-Sibilot, Denis, Soria, Jean-Charles, Brambilla, Christian, Brambilla, Elizabeth
Format:	Journal Article
Language:	English
Published:	United States 01.06.2010
Subjects:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma, Bronchiolo-Alveolar - genetics Adenocarcinoma, Bronchiolo-Alveolar - metabolism Ataxia Telangiectasia Mutated Proteins Carcinoma, Squamous Cell - genetics Cell Cycle Proteins - metabolism Checkpoint Kinase 2 Disease Progression DNA Damage DNA-Binding Proteins - metabolism Histones - metabolism Hyperplasia - pathology Immunohistochemistry Lung - metabolism Lung - pathology Lung Neoplasms - genetics Lung Neoplasms - metabolism Precancerous Conditions - genetics Precancerous Conditions - metabolism Protein-Serine-Threonine Kinases - metabolism Telomere - ultrastructure Telomeric Repeat Binding Protein 1 - metabolism Telomeric Repeat Binding Protein 2 - metabolism Tumor Suppressor Proteins - metabolism
ISSN:	1078-0432, 1557-3265, 1557-3265
Online Access:	Get more information
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