WBSMDA: Within and Between Score for MiRNA-Disease Association prediction

Increasing evidences have indicated that microRNAs (miRNAs) are functionally associated with the development and progression of various complex human diseases. However, the roles of miRNAs in multiple biological processes or various diseases and their underlying molecular mechanisms still have not b...

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Veröffentlicht in:	Scientific reports Jg. 6; H. 1; S. 21106
Hauptverfasser:	Chen, Xing, Yan, Chenggang Clarence, Zhang, Xu, You, Zhu-Hong, Deng, Lixi, Liu, Ying, Zhang, Yongdong, Dai, Qionghai
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 16.02.2016 Nature Publishing Group
Schlagworte:	631/114/2397 631/337/384/331 631/553/2695 Algorithms Colon Colorectal cancer Computational Biology - methods Computer applications Disease Genetic Association Studies - methods Genetic Predisposition to Disease Humanities and Social Sciences Humans Lymphoma MicroRNAs - genetics miRNA Molecular modelling multidisciplinary Neoplasms - genetics Prostate Prostate cancer Reproducibility of Results ROC Curve Science Tumors
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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Abstract	Increasing evidences have indicated that microRNAs (miRNAs) are functionally associated with the development and progression of various complex human diseases. However, the roles of miRNAs in multiple biological processes or various diseases and their underlying molecular mechanisms still have not been fully understood yet. Predicting potential miRNA-disease associations by integrating various heterogeneous biological datasets is of great significance to the biomedical research. Computational methods could obtain potential miRNA-disease associations in a short time, which significantly reduce the experimental time and cost. Considering the limitations in previous computational methods, we developed the model of Within and Between Score for MiRNA-Disease Association prediction (WBSMDA) to predict potential miRNAs associated with various complex diseases. WBSMDA could be applied to the diseases without any known related miRNAs. The AUC of 0.8031 based on Leave-one-out cross validation has demonstrated its reliable performance. WBSMDA was further applied to Colon Neoplasms, Prostate Neoplasms and Lymphoma for the identification of their potential related miRNAs. As a result, 90%, 84% and 80% of predicted miRNA-disease pairs in the top 50 prediction list for these three diseases have been confirmed by recent experimental literatures, respectively. It is anticipated that WBSMDA would be a useful resource for potential miRNA-disease association identification.
AbstractList	Increasing evidences have indicated that microRNAs (miRNAs) are functionally associated with the development and progression of various complex human diseases. However, the roles of miRNAs in multiple biological processes or various diseases and their underlying molecular mechanisms still have not been fully understood yet. Predicting potential miRNA-disease associations by integrating various heterogeneous biological datasets is of great significance to the biomedical research. Computational methods could obtain potential miRNA-disease associations in a short time, which significantly reduce the experimental time and cost. Considering the limitations in previous computational methods, we developed the model of Within and Between Score for MiRNA-Disease Association prediction (WBSMDA) to predict potential miRNAs associated with various complex diseases. WBSMDA could be applied to the diseases without any known related miRNAs. The AUC of 0.8031 based on Leave-one-out cross validation has demonstrated its reliable performance. WBSMDA was further applied to Colon Neoplasms, Prostate Neoplasms, and Lymphoma for the identification of their potential related miRNAs. As a result, 90%, 84%, and 80% of predicted miRNA-disease pairs in the top 50 prediction list for these three diseases have been confirmed by recent experimental literatures, respectively. It is anticipated that WBSMDA would be a useful resource for potential miRNA-disease association identification. Increasing evidences have indicated that microRNAs (miRNAs) are functionally associated with the development and progression of various complex human diseases. However, the roles of miRNAs in multiple biological processes or various diseases and their underlying molecular mechanisms still have not been fully understood yet. Predicting potential miRNA-disease associations by integrating various heterogeneous biological datasets is of great significance to the biomedical research. Computational methods could obtain potential miRNA-disease associations in a short time, which significantly reduce the experimental time and cost. Considering the limitations in previous computational methods, we developed the model of Within and Between Score for MiRNA-Disease Association prediction (WBSMDA) to predict potential miRNAs associated with various complex diseases. WBSMDA could be applied to the diseases without any known related miRNAs. The AUC of 0.8031 based on Leave-one-out cross validation has demonstrated its reliable performance. WBSMDA was further applied to Colon Neoplasms, Prostate Neoplasms, and Lymphoma for the identification of their potential related miRNAs. As a result, 90%, 84%, and 80% of predicted miRNA-disease pairs in the top 50 prediction list for these three diseases have been confirmed by recent experimental literatures, respectively. It is anticipated that WBSMDA would be a useful resource for potential miRNA-disease association identification.Increasing evidences have indicated that microRNAs (miRNAs) are functionally associated with the development and progression of various complex human diseases. However, the roles of miRNAs in multiple biological processes or various diseases and their underlying molecular mechanisms still have not been fully understood yet. Predicting potential miRNA-disease associations by integrating various heterogeneous biological datasets is of great significance to the biomedical research. Computational methods could obtain potential miRNA-disease associations in a short time, which significantly reduce the experimental time and cost. Considering the limitations in previous computational methods, we developed the model of Within and Between Score for MiRNA-Disease Association prediction (WBSMDA) to predict potential miRNAs associated with various complex diseases. WBSMDA could be applied to the diseases without any known related miRNAs. The AUC of 0.8031 based on Leave-one-out cross validation has demonstrated its reliable performance. WBSMDA was further applied to Colon Neoplasms, Prostate Neoplasms, and Lymphoma for the identification of their potential related miRNAs. As a result, 90%, 84%, and 80% of predicted miRNA-disease pairs in the top 50 prediction list for these three diseases have been confirmed by recent experimental literatures, respectively. It is anticipated that WBSMDA would be a useful resource for potential miRNA-disease association identification.
ArticleNumber	21106
Author	Yan, Chenggang Clarence Liu, Ying You, Zhu-Hong Chen, Xing Zhang, Xu Zhang, Yongdong Deng, Lixi Dai, Qionghai
Author_xml	– sequence: 1 givenname: Xing surname: Chen fullname: Chen, Xing organization: National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Academy of Mathematics and Systems Science, Chinese Academy of Sciences – sequence: 2 givenname: Chenggang Clarence surname: Yan fullname: Yan, Chenggang Clarence organization: Institute of Information and Control, Hangzhou Dianzi University, Department of Automation, Tsinghua University – sequence: 3 givenname: Xu surname: Zhang fullname: Zhang, Xu organization: School of Mechanical, Electrical & Information Engineering, Shandong University – sequence: 4 givenname: Zhu-Hong surname: You fullname: You, Zhu-Hong organization: School of Computer Science and Technology, China University of Mining and Technology – sequence: 5 givenname: Lixi surname: Deng fullname: Deng, Lixi organization: Institute of Computing Technology, Chinese Academy of Sciences, University of Chinese Academy of Sciences – sequence: 6 givenname: Ying surname: Liu fullname: Liu, Ying organization: School of Economics and Management, Beihang University – sequence: 7 givenname: Yongdong surname: Zhang fullname: Zhang, Yongdong organization: Key Lab of Intelligent Information Processing of Chinese Academy of Sciences, Institute of Computing Technology, Chinese Academy of Sciences – sequence: 8 givenname: Qionghai surname: Dai fullname: Dai, Qionghai organization: Department of Automation, Tsinghua University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26880032$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1038/nature02871 10.1126/science.1121566 10.1038/nature06487 10.1038/srep13877 10.1089/omi.2009.0143 10.1016/j.cell.2009.01.002 10.1101/gad.1974211 10.1186/1471-2407-9-374 10.1038/nbt1203 10.1593/neo.08980 10.1126/science.1149460 10.1186/1752-0509-7-101 10.1016/S0092-8674(01)00616-X 10.1038/onc.2013.77 10.1016/j.ajhg.2008.02.013 10.1038/nrc1840 10.1016/j.lungcan.2011.12.018 10.1111/febs.12236 10.1093/nar/gkq1027 10.1016/j.bbrc.2008.09.086 10.1093/nar/gkm480 10.1371/journal.pone.0096670 10.1038/srep13186 10.1161/CIRCRESAHA.107.163147 10.3322/caac.20107 10.1158/1535-7163.MCT-11-0055 10.1016/S0092-8674(04)00045-5 10.1186/1752-0509-4-S1-S2 10.1186/1471-2156-6-45 10.1371/journal.pone.0003420 10.1093/bioinformatics/btt677 10.1038/srep11338 10.1158/0008-5472.CAN-07-0533 10.1158/0008-5472.CAN-09-1448 10.1371/journal.pone.0043425 10.1016/j.tig.2004.09.010 10.1093/nar/gkj112 10.1016/j.febslet.2014.09.045 10.1038/srep05501 10.1039/c2mb25180a 10.1016/j.crvi.2005.12.006 10.1016/j.cell.2009.03.047 10.1073/pnas.0510565103 10.1038/nature02873 10.1016/j.gde.2005.08.005 10.1186/1471-2164-11-S4-S5 10.1038/msb4100089 10.1111/iju.12700 10.1038/srep16840 10.1002/gcc.20917 10.1182/blood-2011-09-381905 10.1186/1471-2105-14-S12-S1 10.1093/bioinformatics/btt426 10.1093/bioinformatics/btq241 10.1039/C4MB00353E 10.1093/nar/gkt1023 10.1093/nar/gki200 10.1002/gcc.20596 10.1371/journal.pone.0046173 10.1093/nar/gkn714 10.1038/ng895 10.1039/c2mb00002d 10.1504/IJDMB.2013.056078 10.1074/jbc.M702806200 10.1182/blood-2011-06-361972 10.1002/pros.20786 10.1371/journal.pone.0092921 10.1038/nrc1997 10.1371/journal.pone.0070204 10.1126/science.1113329 10.1093/carcin/bgp094 10.3322/caac.21166
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors contributed equally to this work.
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References	Ambros (CR1) 2004; 431 Calin, Croce (CR29) 2006; 6 Kozomara, Griffiths-Jones (CR8) 2011; 39 Yang (CR53) 2010; 11 Bartel (CR2) 2004; 116 Jiang, Wang, Jin, Li, Wang (CR31) 2013; 8 Goto, Kurozumi, Enokida, Ichikawa, Seki (CR66) 2015; 22 Chen, Liu, Yan (CR37) 2012; 8 Xu (CR50) 2014; 10 Griffiths‐Jones (CR16) 2010; 12 Mørk, Pletscher-Frankild, Caro, Gorodkin, Jensen (CR49) 2013; 30 Sun (CR70) 2014; 33 Png (CR21) 2011; 25 Chen, Liu, Cui, Yan (CR38) 2012; 7 Xuan (CR43) 2013; 8 Fujita (CR73) 2008; 377 Bartel (CR14) 2009; 136 Xu (CR47) 2011; 10 Guo (CR58) 2008; 47 Gibcus (CR61) 2009; 11 Mu, Deng, Fan (CR67) 2015; 6 Shi, Liu, Yu, Li (CR75) 2015; 2015 Miska (CR11) 2005; 15 Ribas (CR25) 2009; 69 Chen (CR34) 2015; 5 Wang, Wang, Lu, Song, Cui (CR74) 2010; 26 Esquela-Kerscher, Slack (CR17) 2006; 6 Cui, Yu, Purisima, Wang (CR15) 2006; 2 Perez-Iratxeta, Wjst, Bork, Andrade (CR40) 2005; 6 Tsang, Kwok (CR59) 2009; 30 Ogata-Kawata (CR54) 2014; 9 Wang (CR26) 2012; 7 Wang (CR27) 2014; 588 Li (CR51) 2014; 42 Cheng, Byrom, Shelton, Ford (CR9) 2005; 33 Leich (CR64) 2011; 118 Xu, Guo, Hay (CR12) 2004; 20 Latronico, Catalucci, Condorelli (CR18) 2007; 101 Chen, Yan (CR35) 2014; 4 Tavazoie (CR22) 2008; 451 Siegel, Naishadham, Jemal (CR68) 2013; 63 Yu (CR20) 2007; 35 Chen (CR39) 2015; 5 Xie (CR62) 2012; 119 Jopling, Yi, Lancaster, Lemon, Sarnow (CR5) 2005; 309 Vasudevan, Tong, Steitz (CR6) 2007; 318 Coiffier (CR63) 2006; 329 Ambros (CR4) 2001; 107 Griffiths-Jones, Grocock, Van Dongen, Bateman, Enright (CR7) 2006; 34 Chen, Liu, Yan (CR45) 2012; 8 Meister, Tuschl (CR3) 2004; 431 Hirota (CR28) 2012; 77 Porkka (CR71) 2007; 67 Volinia (CR24) 2006; 103 Prueitt (CR72) 2008; 68 Uhl, Krimer, Schliekelman, Tompkins, Suter (CR65) 2011; 50 Chen (CR33) 2015; 5 Karp, Ambros (CR10) 2005; 310 Chen, Yan, Liao (CR46) 2010; 14 Drusco (CR56) 2014; 9 Perez-Iratxeta, Bork, Andrade (CR41) 2002; 31 Arndt (CR60) 2009; 9 Köhler, Bauer, Horn, Robinson (CR44) 2008; 82 Valastyan (CR23) 2009; 137 Lu (CR19) 2008; 3 Jiang (CR52) 2009; 37 Chen (CR32) 2015; 5 Aerts (CR42) 2006; 24 Jiang (CR30) 2010; 4 Shi, Sepp-Lorenzino, Prisco, Linsley, Baserga (CR57) 2007; 282 Alshalalfa, Alhajj (CR13) 2013; 14 Hart (CR69) 2013; 280 Shi (CR48) 2013; 7 Chen, Yan (CR36) 2013; 29 Jemal (CR55) 2011; 61 GA Calin (BFsrep21106_CR29) 2006; 6 KJ Png (BFsrep21106_CR21) 2011; 25 JH Gibcus (BFsrep21106_CR61) 2009; 11 X Chen (BFsrep21106_CR33) 2015; 5 DP Bartel (BFsrep21106_CR2) 2004; 116 KP Porkka (BFsrep21106_CR71) 2007; 67 V Ambros (BFsrep21106_CR1) 2004; 431 Y Goto (BFsrep21106_CR66) 2015; 22 S Griffiths‐Jones (BFsrep21106_CR16) 2010; 12 P Mu (BFsrep21106_CR67) 2015; 6 MV Latronico (BFsrep21106_CR18) 2007; 101 Y Li (BFsrep21106_CR51) 2014; 42 C Perez-Iratxeta (BFsrep21106_CR40) 2005; 6 P Xuan (BFsrep21106_CR43) 2013; 8 X Chen (BFsrep21106_CR39) 2015; 5 X Chen (BFsrep21106_CR38) 2012; 7 C Perez-Iratxeta (BFsrep21106_CR41) 2002; 31 S Mørk (BFsrep21106_CR49) 2013; 30 EA Miska (BFsrep21106_CR11) 2005; 15 S Volinia (BFsrep21106_CR24) 2006; 103 B Shi (BFsrep21106_CR57) 2007; 282 X Chen (BFsrep21106_CR32) 2015; 5 E Uhl (BFsrep21106_CR65) 2011; 50 R Wang (BFsrep21106_CR26) 2012; 7 WP Tsang (BFsrep21106_CR59) 2009; 30 S Valastyan (BFsrep21106_CR23) 2009; 137 J Ribas (BFsrep21106_CR25) 2009; 69 X Chen (BFsrep21106_CR36) 2013; 29 X Chen (BFsrep21106_CR37) 2012; 8 B Coiffier (BFsrep21106_CR63) 2006; 329 Q Jiang (BFsrep21106_CR30) 2010; 4 R Wang (BFsrep21106_CR27) 2014; 588 Q Jiang (BFsrep21106_CR31) 2013; 8 Z Yang (BFsrep21106_CR53) 2010; 11 CL Jopling (BFsrep21106_CR5) 2005; 309 X Karp (BFsrep21106_CR10) 2005; 310 M Lu (BFsrep21106_CR19) 2008; 3 H Shi (BFsrep21106_CR48) 2013; 7 X Chen (BFsrep21106_CR46) 2010; 14 R Siegel (BFsrep21106_CR68) 2013; 63 M Hart (BFsrep21106_CR69) 2013; 280 A Jemal (BFsrep21106_CR55) 2011; 61 M Alshalalfa (BFsrep21106_CR13) 2013; 14 T Hirota (BFsrep21106_CR28) 2012; 77 A Drusco (BFsrep21106_CR56) 2014; 9 GM Arndt (BFsrep21106_CR60) 2009; 9 S Vasudevan (BFsrep21106_CR6) 2007; 318 D Sun (BFsrep21106_CR70) 2014; 33 S Aerts (BFsrep21106_CR42) 2006; 24 X Chen (BFsrep21106_CR34) 2015; 5 S Köhler (BFsrep21106_CR44) 2008; 82 SF Tavazoie (BFsrep21106_CR22) 2008; 451 Q Cui (BFsrep21106_CR15) 2006; 2 H Ogata-Kawata (BFsrep21106_CR54) 2014; 9 D Wang (BFsrep21106_CR74) 2010; 26 A Esquela-Kerscher (BFsrep21106_CR17) 2006; 6 X Chen (BFsrep21106_CR35) 2014; 4 C Xu (BFsrep21106_CR50) 2014; 10 G Meister (BFsrep21106_CR3) 2004; 431 L Xie (BFsrep21106_CR62) 2012; 119 DP Bartel (BFsrep21106_CR14) 2009; 136 X Chen (BFsrep21106_CR45) 2012; 8 RL Prueitt (BFsrep21106_CR72) 2008; 68 AM Cheng (BFsrep21106_CR9) 2005; 33 Z Yu (BFsrep21106_CR20) 2007; 35 J Xu (BFsrep21106_CR47) 2011; 10 Y Fujita (BFsrep21106_CR73) 2008; 377 S Griffiths-Jones (BFsrep21106_CR7) 2006; 34 C Guo (BFsrep21106_CR58) 2008; 47 V Ambros (BFsrep21106_CR4) 2001; 107 E Leich (BFsrep21106_CR64) 2011; 118 P Xu (BFsrep21106_CR12) 2004; 20 A Kozomara (BFsrep21106_CR8) 2011; 39 Q Jiang (BFsrep21106_CR52) 2009; 37 J-Y Shi (BFsrep21106_CR75) 2015; 2015 16381832 - Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4 12006977 - Nat Genet. 2002 Jul;31(3):316-9 17827156 - J Biol Chem. 2007 Nov 9;282(45):32582-90 18063818 - Circ Res. 2007 Dec 7;101(12):1225-36 20439255 - Bioinformatics. 2010 Jul 1;26(13):1644-50 24975600 - Sci Rep. 2014;4:5501 18663744 - Genes Chromosomes Cancer. 2008 Nov;47(11):939-46 26278472 - Sci Rep. 2015;5:13186 21037258 - Nucleic Acids Res. 2011 Jan;39(Database issue):D152-7 21910161 - Genes Chromosomes Cancer. 2011 Nov;50(11):950-67 24267745 - BMC Bioinformatics. 2013;14 Suppl 12:S1 17584784 - Nucleic Acids Res. 2007;35(13):4535-41 24705249 - PLoS One. 2014;9(4):e92921 20522252 - BMC Syst Biol. 2010;4 Suppl 1:S2 16099643 - Curr Opin Genet Dev. 2005 Oct;15(5):563-8 22306127 - Lung Cancer. 2012 Jul;77(1):16-23 16141076 - Science. 2005 Sep 2;309(5740):1577-81 23480797 - FEBS J. 2013 May;280(9):2105-16 17060945 - Nat Rev Cancer. 2006 Nov;6(11):857-66 23335087 - CA Cancer J Clin. 2013 Jan;63(1):11-30 15372042 - Nature. 2004 Sep 16;431(7006):350-5 15522457 - Trends Genet. 2004 Dec;20(12):617-24 26347258 - Sci Rep. 2015;5:13877 23950912 - PLoS One. 2013;8(8):e70204 16557279 - Nat Rev Cancer. 2006 Apr;6(4):259-69 21143814 - BMC Genomics. 2010;11 Suppl 4:S5 16969338 - Mol Syst Biol. 2006;2:46 24194601 - Nucleic Acids Res. 2014 Jan;42(Database issue):D1070-4 18834855 - Biochem Biophys Res Commun. 2008 Dec 5;377(1):114-9 26543857 - Biomed Res Int. 2015;2015:350983 16680138 - Nat Biotechnol. 2006 May;24(5):537-44 21768329 - Mol Cancer Ther. 2011 Oct;10(10):1857-66 11779458 - Cell. 2001 Dec 28;107(7):823-6 24273243 - Bioinformatics. 2014 Feb 1;30(3):392-7 22937049 - PLoS One. 2012;7(8):e43425 24921248 - PLoS One. 2014;9(6):e96670 16461460 - Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61 16644494 - C R Biol. 2006 Apr;329(4):241-54 18459106 - Prostate. 2008 Aug 1;68(11):1152-64 14744438 - Cell. 2004 Jan 23;116(2):281-97 21289068 - Genes Dev. 2011 Feb 1;25(3):226-31 26061969 - Sci Rep. 2015;5:11338 15741182 - Nucleic Acids Res. 2005;33(4):1290-7 21296855 - CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90 22875290 - Mol Biosyst. 2012 Oct;8(10):2792-8 19738047 - Cancer Res. 2009 Sep 15;69(18):7165-9 24417022 - Int J Data Min Bioinform. 2013;8(3):282-93 18371930 - Am J Hum Genet. 2008 Apr;82(4):949-58 20726795 - OMICS. 2010 Aug;14(4):337-56 26577439 - Sci Rep. 2015;5:16840 25448984 - FEBS Lett. 2014 Nov 28;588(23):4438-47 23503464 - Oncogene. 2014 Mar 13;33(11):1448-57 18185580 - Nature. 2008 Jan 10;451(7175):147-52 25099736 - Mol Biosyst. 2014 Nov;10(11):2800-9 21960592 - Blood. 2011 Nov 17;118(20):5550-8 18927107 - Nucleic Acids Res. 2009 Jan;37(Database issue):D98-104 24103777 - BMC Syst Biol. 2013;7:101 19167326 - Cell. 2009 Jan 23;136(2):215-33 22538619 - Mol Biosyst. 2012 Jul 6;8(7):1970-8 19177201 - Neoplasia. 2009 Feb;11(2):167-76 18923704 - PLoS One. 2008;3(10):e3420 19524507 - Cell. 2009 Jun 12;137(6):1032-46 18048652 - Science. 2007 Dec 21;318(5858):1931-4 16115313 - BMC Genet. 2005;6:45 23071542 - PLoS One. 2012;7(10):e46173 19372139 - Carcinogenesis. 2009 Jun;30(6):953-9 17616669 - Cancer Res. 2007 Jul 1;67(13):6130-5 15372041 - Nature. 2004 Sep 16;431(7006):343-9 22343918 - Blood. 2012 Apr 12;119(15):3503-11 24002109 - Bioinformatics. 2013 Oct 15;29(20):2617-24 19843336 - BMC Cancer. 2009;9:374 25599923 - Int J Urol. 2015 Mar;22(3):242-52 16311325 - Science. 2005 Nov 25;310(5752):1288-9
References_xml	– volume: 4 start-page: S2 year: 2010 ident: CR30 article-title: Prioritization of disease microRNAs through a human phenome-microRNAome network publication-title: BMC Syst Biol – volume: 30 start-page: 392 year: 2013 end-page: 397 ident: CR49 article-title: Protein-driven inference of miRNA–disease associations publication-title: Bioinformatics – volume: 68 start-page: 1152 year: 2008 end-page: 1164 ident: CR72 article-title: Expression of microRNAs and protein-coding genes associated with perineural invasion in prostate cancer publication-title: Prostate – volume: 8 start-page: e70204 year: 2013 ident: CR43 article-title: Prediction of microRNAs Associated with Human Diseases Based on Weighted k Most Similar Neighbors publication-title: PLoS One – volume: 82 start-page: 949 year: 2008 ident: CR44 article-title: Walking the interactome for prioritization of candidate disease genes publication-title: Am J Hum Genet – volume: 35 start-page: 4535 year: 2007 end-page: 4541 ident: CR20 article-title: Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers publication-title: Nucleic Acids Res – volume: 5 start-page: 11338 year: 2015 ident: CR34 article-title: Constructing lncRNA functional similarity network based on lncRNA-disease associations and disease semantic similarity publication-title: Sci Rep – volume: 63 start-page: 11 year: 2013 end-page: 30 ident: CR68 article-title: Cancer statistics, 2013 publication-title: CA Cancer J Clin. – volume: 12 start-page: 1 year: 2010 end-page: 10 ident: CR16 article-title: miRBase: microRNA sequences and annotation publication-title: Curr Protoc Bioinformatics. – volume: 8 start-page: 2792 year: 2012 end-page: 2798 ident: CR37 article-title: RWRMDA: predicting novel human microRNA–disease associations publication-title: Mol Biosyst – volume: 103 start-page: 2257 year: 2006 end-page: 2261 ident: CR24 article-title: A microRNA expression signature of human solid tumors defines cancer gene targets publication-title: Proc Natl Acad Sci USA. – volume: 431 start-page: 350 year: 2004 end-page: 355 ident: CR1 article-title: The functions of animal microRNAs publication-title: Nature doi: 10.1038/nature02871 – volume: 6 start-page: 2 year: 2015 ident: CR67 article-title: MicroRNAs in Prostate Cancer: Small RNAs with Big Roles publication-title: J Clin Cell Immunol – volume: 431 start-page: 343 year: 2004 end-page: 349 ident: CR3 article-title: Mechanisms of gene silencing by double-stranded RNA publication-title: Nature – volume: 11 start-page: S5 year: 2010 ident: CR53 article-title: dbDEMC: a database of differentially expressed miRNAs in human cancers publication-title: BMC Genomics. – volume: 451 start-page: 147 year: 2008 end-page: 152 ident: CR22 article-title: Endogenous human microRNAs that suppress breast cancer metastasis publication-title: Nature – volume: 318 start-page: 1931 year: 2007 end-page: 1934 ident: CR6 article-title: Switching from repression to activation: microRNAs can up-regulate translation publication-title: Science – volume: 10 start-page: 2800 year: 2014 end-page: 2809 ident: CR50 article-title: Prioritizing candidate disease miRNAs by integrating phenotype associations of multiple diseases with matched miRNA and mRNA expression profiles publication-title: Mol BioSyst. – volume: 42 start-page: D1070 year: 2014 end-page: D1074 ident: CR51 article-title: HMDD v2.0: a database for experimentally supported human microRNA and disease associations publication-title: Nucleic Acids Res – volume: 7 start-page: 101 year: 2013 ident: CR48 article-title: Walking the interactome to identify human miRNA-disease associations through the functional link between miRNA targets and disease genes publication-title: BMC Syst Biol – volume: 2 start-page: 46 year: 2006 ident: CR15 article-title: Principles of microRNA regulation of a human cellular signaling network publication-title: Mol Syst Biol – volume: 31 start-page: 316 year: 2002 end-page: 319 ident: CR41 article-title: Association of genes to genetically inherited diseases using data mining publication-title: Nature Gene – volume: 9 start-page: e96670 year: 2014 ident: CR56 article-title: MicroRNA profiles discriminate among colon cancer metastasis publication-title: PLoS One. – volume: 6 start-page: 857 year: 2006 end-page: 866 ident: CR29 article-title: MicroRNA signatures in human cancers publication-title: Nat Rev Cancer – volume: 61 start-page: 69 year: 2011 end-page: 90 ident: CR55 article-title: Global cancer statistics publication-title: CA Cancer J Clin. – volume: 22 start-page: 242 year: 2015 end-page: 252 ident: CR66 article-title: Functional significance of aberrantly expressed microRNAs in prostate cancer publication-title: Int J Urol – volume: 136 start-page: 215 year: 2009 end-page: 233 ident: CR14 article-title: MicroRNAs: target recognition and regulatory functions publication-title: Cell – volume: 101 start-page: 1225 year: 2007 end-page: 1236 ident: CR18 article-title: Emerging role of microRNAs in cardiovascular biology publication-title: Circ Res – volume: 29 start-page: 2617 year: 2013 end-page: 2624 ident: CR36 article-title: Novel human lncRNA–disease association inference based on lncRNA expression profiles publication-title: Bioinformatics – volume: 2015 start-page: 350983 year: 2015 ident: CR75 article-title: Predicting Drug-Target Interactions via Within-Score and Between-Score publication-title: Biomed Res Int – volume: 5 start-page: 13186 year: 2015 ident: CR32 article-title: Predicting lncRNA-disease associations and constructing lncRNA functional similarity network based on the information of miRNA publication-title: Sci Rep – volume: 5 start-page: 16840 year: 2015 ident: CR39 article-title: KATZLDA: KATZ measure for the lncRNA-disease association prediction publication-title: Sci Rep – volume: 50 start-page: 950 year: 2011 end-page: 967 ident: CR65 article-title: Identification of altered MicroRNA expression in canine lymphoid cell lines and cases of B‐and T‐Cell lymphomas publication-title: GENE CHROMOSOME CANC – volume: 6 start-page: 259 year: 2006 end-page: 269 ident: CR17 article-title: Oncomirs—microRNAs with a role in cancer publication-title: Nat Rev Cancer – volume: 15 start-page: 563 year: 2005 end-page: 568 ident: CR11 article-title: How microRNAs control cell division, differentiation and death publication-title: Curr Opin Genet Dev – volume: 30 start-page: 953 year: 2009 end-page: 959 ident: CR59 article-title: The miR-18a* microRNA functions as a potential tumor suppressor by targeting on K-Ras publication-title: Carcinogenesis – volume: 377 start-page: 114 year: 2008 end-page: 119 ident: CR73 article-title: Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells publication-title: Biochem Biophys Res Commun. – volume: 5 start-page: 13877 year: 2015 ident: CR33 article-title: RBMMMDA: predicting multiple types of disease-microRNA associations publication-title: Sci Rep – volume: 282 start-page: 32582 year: 2007 end-page: 32590 ident: CR57 article-title: Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells publication-title: J Biol Chem. – volume: 47 start-page: 939 year: 2008 end-page: 946 ident: CR58 article-title: The noncoding RNA, miR‐126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3‐kinase signaling and is frequently lost in colon cancers publication-title: GENE CHROMOSOME CANC – volume: 67 start-page: 6130 year: 2007 end-page: 6135 ident: CR71 article-title: MicroRNA expression profiling in prostate cancer publication-title: Cancer Res – volume: 4 start-page: 5501 year: 2014 ident: CR35 article-title: Semi-supervised learning for potential human microRNA-disease associations inference publication-title: Sci Rep – volume: 137 start-page: 1032 year: 2009 end-page: 1046 ident: CR23 article-title: A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis publication-title: Cell – volume: 6 start-page: 45 year: 2005 ident: CR40 article-title: G2D: a tool for mining genes associated with disease publication-title: BMC Gene – volume: 3 start-page: e3420 year: 2008 ident: CR19 article-title: An analysis of human microRNA and disease associations publication-title: PLoS One – volume: 37 start-page: D98 year: 2009 end-page: D104 ident: CR52 article-title: miR2Disease: a manually curated database for microRNA deregulation in human disease publication-title: Nucleic Acids Res – volume: 24 start-page: 537 year: 2006 end-page: 544 ident: CR42 article-title: Gene prioritization through genomic data fusion publication-title: Nat Biotechnol – volume: 7 start-page: e46173 year: 2012 ident: CR26 article-title: MiR-101 is involved in human breast carcinogenesis by targeting Stathmin1 publication-title: PLoS One. – volume: 10 start-page: 1857 year: 2011 end-page: 1866 ident: CR47 article-title: Prioritizing candidate disease miRNAs by topological features in the miRNA target–dysregulated network: Case study of prostate cancer publication-title: Mol Cancer Ther – volume: 26 start-page: 1644 year: 2010 end-page: 1650 ident: CR74 article-title: Inferring the human microRNA functional similarity and functional network based on microRNA-associated diseases publication-title: Bioinformatics – volume: 310 start-page: 1288 year: 2005 end-page: 1289 ident: CR10 article-title: Encountering microRNAs in cell fate signaling publication-title: Science – volume: 34 start-page: D140 year: 2006 end-page: D144 ident: CR7 article-title: J. miRBase: microRNA sequences, targets and gene nomenclature publication-title: Nucleic Acids Res – volume: 11 start-page: 167 year: 2009 end-page: 176 ident: CR61 article-title: Hodgkin lymphoma cell lines are characterized by a specific miRNA expression profile publication-title: Neoplasia – volume: 77 start-page: 16 year: 2012 end-page: 23 ident: CR28 article-title: Dihydropyrimidine dehydrogenase (DPD) expression is negatively regulated by certain microRNAs in human lung tissues publication-title: Lung Cancer – volume: 107 start-page: 823 year: 2001 end-page: 826 ident: CR4 article-title: microRNAs: tiny regulators with great potential publication-title: Cell – volume: 39 start-page: D152 year: 2011 end-page: D157 ident: CR8 article-title: miRBase: integrating microRNA annotation and deep-sequencing data publication-title: Nucleic Acids Res – volume: 588 start-page: 4438 year: 2014 end-page: 4447 ident: CR27 article-title: MiR-185 is involved in human breast carcinogenesis by targeting Vegfa publication-title: FEBS letters – volume: 8 start-page: 282 year: 2013 end-page: 293 ident: CR31 article-title: Predicting human microRNA-disease associations based on support vector machine publication-title: Int J Data Min Bioinform – volume: 118 start-page: 5550 year: 2011 end-page: 5558 ident: CR64 article-title: MicroRNA profiles of t (14; 18)–negative follicular lymphoma support a late germinal center B-cell phenotype publication-title: Blood – volume: 7 start-page: e43425 year: 2012 ident: CR38 article-title: Prediction of Disease-Related Interactions between MicroRNAs and Environmental Factors Based on a Semi-Supervised Classifier publication-title: PloS One – volume: 119 start-page: 3503 year: 2012 end-page: 3511 ident: CR62 article-title: FOXO1 is a tumor suppressor in classical Hodgkin lymphoma publication-title: Blood – volume: 329 start-page: 241 year: 2006 end-page: 254 ident: CR63 article-title: Monoclonal antibody as therapy for malignant lymphomas publication-title: C R Biol. – volume: 33 start-page: 1448 year: 2014 end-page: 1457 ident: CR70 article-title: Regulation of several androgen-induced genes through the repression of the miR-99a/let-7c/miR-125b-2 miRNA cluster in prostate cancer cells publication-title: Oncogene – volume: 9 start-page: e92921 year: 2014 ident: CR54 article-title: Circulating exosomal microRNAs as biomarkers of colon cancer publication-title: PLoS One – volume: 14 start-page: S1 year: 2013 ident: CR13 article-title: Using context-specific effect of miRNAs to identify functional associations between miRNAs and gene signatures publication-title: BMC bioinformatics – volume: 69 start-page: 7165 year: 2009 end-page: 7169 ident: CR25 article-title: miR-21: an androgen receptor–regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth publication-title: Cancer Res – volume: 25 start-page: 226 year: 2011 end-page: 231 ident: CR21 article-title: MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer publication-title: Genes Dev – volume: 309 start-page: 1577 year: 2005 end-page: 1581 ident: CR5 article-title: Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA publication-title: Science – volume: 20 start-page: 617 year: 2004 end-page: 624 ident: CR12 article-title: MicroRNAs and the regulation of cell death publication-title: Trends Genet – volume: 9 start-page: 374 year: 2009 ident: CR60 article-title: Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer publication-title: BMC cancer – volume: 116 start-page: 281 year: 2004 end-page: 297 ident: CR2 article-title: MicroRNAs: genomics, biogenesis, mechanism and function publication-title: Cell – volume: 33 start-page: 1290 year: 2005 end-page: 1297 ident: CR9 article-title: Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis publication-title: Nucleic Acids Res – volume: 8 start-page: 1970 year: 2012 end-page: 1978 ident: CR45 article-title: Drug–target interaction prediction by random walk on the heterogeneous network publication-title: Mol Biosyst – volume: 14 start-page: 337 year: 2010 end-page: 356 ident: CR46 article-title: A novel candidate disease genes prioritization method based on module partition and rank fusion publication-title: OMICS – volume: 280 start-page: 2105 year: 2013 end-page: 2116 ident: CR69 article-title: The proto‐oncogene ERG is a target of microRNA miR‐145 in prostate cancer publication-title: FEBS J. – volume: 310 start-page: 1288 year: 2005 ident: BFsrep21106_CR10 publication-title: Science doi: 10.1126/science.1121566 – volume: 451 start-page: 147 year: 2008 ident: BFsrep21106_CR22 publication-title: Nature doi: 10.1038/nature06487 – volume: 5 start-page: 13877 year: 2015 ident: BFsrep21106_CR33 publication-title: Sci Rep doi: 10.1038/srep13877 – volume: 14 start-page: 337 year: 2010 ident: BFsrep21106_CR46 publication-title: OMICS doi: 10.1089/omi.2009.0143 – volume: 136 start-page: 215 year: 2009 ident: BFsrep21106_CR14 publication-title: Cell doi: 10.1016/j.cell.2009.01.002 – volume: 25 start-page: 226 year: 2011 ident: BFsrep21106_CR21 publication-title: Genes Dev doi: 10.1101/gad.1974211 – volume: 9 start-page: 374 year: 2009 ident: BFsrep21106_CR60 publication-title: BMC cancer doi: 10.1186/1471-2407-9-374 – volume: 24 start-page: 537 year: 2006 ident: BFsrep21106_CR42 publication-title: Nat Biotechnol doi: 10.1038/nbt1203 – volume: 11 start-page: 167 year: 2009 ident: BFsrep21106_CR61 publication-title: Neoplasia doi: 10.1593/neo.08980 – volume: 431 start-page: 350 year: 2004 ident: BFsrep21106_CR1 publication-title: Nature doi: 10.1038/nature02871 – volume: 318 start-page: 1931 year: 2007 ident: BFsrep21106_CR6 publication-title: Science doi: 10.1126/science.1149460 – volume: 7 start-page: 101 year: 2013 ident: BFsrep21106_CR48 publication-title: BMC Syst Biol doi: 10.1186/1752-0509-7-101 – volume: 107 start-page: 823 year: 2001 ident: BFsrep21106_CR4 publication-title: Cell doi: 10.1016/S0092-8674(01)00616-X – volume: 33 start-page: 1448 year: 2014 ident: BFsrep21106_CR70 publication-title: Oncogene doi: 10.1038/onc.2013.77 – volume: 82 start-page: 949 year: 2008 ident: BFsrep21106_CR44 publication-title: Am J Hum Genet doi: 10.1016/j.ajhg.2008.02.013 – volume: 6 start-page: 259 year: 2006 ident: BFsrep21106_CR17 publication-title: Nat Rev Cancer doi: 10.1038/nrc1840 – volume: 2015 start-page: 350983 year: 2015 ident: BFsrep21106_CR75 publication-title: Biomed Res Int – volume: 77 start-page: 16 year: 2012 ident: BFsrep21106_CR28 publication-title: Lung Cancer doi: 10.1016/j.lungcan.2011.12.018 – volume: 280 start-page: 2105 year: 2013 ident: BFsrep21106_CR69 publication-title: FEBS J. doi: 10.1111/febs.12236 – volume: 39 start-page: D152 year: 2011 ident: BFsrep21106_CR8 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkq1027 – volume: 377 start-page: 114 year: 2008 ident: BFsrep21106_CR73 publication-title: Biochem Biophys Res Commun. doi: 10.1016/j.bbrc.2008.09.086 – volume: 35 start-page: 4535 year: 2007 ident: BFsrep21106_CR20 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkm480 – volume: 9 start-page: e96670 year: 2014 ident: BFsrep21106_CR56 publication-title: PLoS One. doi: 10.1371/journal.pone.0096670 – volume: 5 start-page: 13186 year: 2015 ident: BFsrep21106_CR32 publication-title: Sci Rep doi: 10.1038/srep13186 – volume: 101 start-page: 1225 year: 2007 ident: BFsrep21106_CR18 publication-title: Circ Res doi: 10.1161/CIRCRESAHA.107.163147 – volume: 61 start-page: 69 year: 2011 ident: BFsrep21106_CR55 publication-title: CA Cancer J Clin. doi: 10.3322/caac.20107 – volume: 10 start-page: 1857 year: 2011 ident: BFsrep21106_CR47 publication-title: Mol Cancer Ther doi: 10.1158/1535-7163.MCT-11-0055 – volume: 116 start-page: 281 year: 2004 ident: BFsrep21106_CR2 publication-title: Cell doi: 10.1016/S0092-8674(04)00045-5 – volume: 4 start-page: S2 year: 2010 ident: BFsrep21106_CR30 publication-title: BMC Syst Biol doi: 10.1186/1752-0509-4-S1-S2 – volume: 6 start-page: 45 year: 2005 ident: BFsrep21106_CR40 publication-title: BMC Gene doi: 10.1186/1471-2156-6-45 – volume: 3 start-page: e3420 year: 2008 ident: BFsrep21106_CR19 publication-title: PLoS One doi: 10.1371/journal.pone.0003420 – volume: 30 start-page: 392 year: 2013 ident: BFsrep21106_CR49 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt677 – volume: 5 start-page: 11338 year: 2015 ident: BFsrep21106_CR34 publication-title: Sci Rep doi: 10.1038/srep11338 – volume: 67 start-page: 6130 year: 2007 ident: BFsrep21106_CR71 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-0533 – volume: 69 start-page: 7165 year: 2009 ident: BFsrep21106_CR25 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-09-1448 – volume: 7 start-page: e43425 year: 2012 ident: BFsrep21106_CR38 publication-title: PloS One doi: 10.1371/journal.pone.0043425 – volume: 20 start-page: 617 year: 2004 ident: BFsrep21106_CR12 publication-title: Trends Genet doi: 10.1016/j.tig.2004.09.010 – volume: 34 start-page: D140 year: 2006 ident: BFsrep21106_CR7 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkj112 – volume: 588 start-page: 4438 year: 2014 ident: BFsrep21106_CR27 publication-title: FEBS letters doi: 10.1016/j.febslet.2014.09.045 – volume: 4 start-page: 5501 year: 2014 ident: BFsrep21106_CR35 publication-title: Sci Rep doi: 10.1038/srep05501 – volume: 8 start-page: 2792 year: 2012 ident: BFsrep21106_CR37 publication-title: Mol Biosyst doi: 10.1039/c2mb25180a – volume: 329 start-page: 241 year: 2006 ident: BFsrep21106_CR63 publication-title: C R Biol. doi: 10.1016/j.crvi.2005.12.006 – volume: 137 start-page: 1032 year: 2009 ident: BFsrep21106_CR23 publication-title: Cell doi: 10.1016/j.cell.2009.03.047 – volume: 103 start-page: 2257 year: 2006 ident: BFsrep21106_CR24 publication-title: Proc Natl Acad Sci USA. doi: 10.1073/pnas.0510565103 – volume: 431 start-page: 343 year: 2004 ident: BFsrep21106_CR3 publication-title: Nature doi: 10.1038/nature02873 – volume: 15 start-page: 563 year: 2005 ident: BFsrep21106_CR11 publication-title: Curr Opin Genet Dev doi: 10.1016/j.gde.2005.08.005 – volume: 11 start-page: S5 year: 2010 ident: BFsrep21106_CR53 publication-title: BMC Genomics. doi: 10.1186/1471-2164-11-S4-S5 – volume: 2 start-page: 46 year: 2006 ident: BFsrep21106_CR15 publication-title: Mol Syst Biol doi: 10.1038/msb4100089 – volume: 22 start-page: 242 year: 2015 ident: BFsrep21106_CR66 publication-title: Int J Urol doi: 10.1111/iju.12700 – volume: 5 start-page: 16840 year: 2015 ident: BFsrep21106_CR39 publication-title: Sci Rep doi: 10.1038/srep16840 – volume: 50 start-page: 950 year: 2011 ident: BFsrep21106_CR65 publication-title: GENE CHROMOSOME CANC doi: 10.1002/gcc.20917 – volume: 119 start-page: 3503 year: 2012 ident: BFsrep21106_CR62 publication-title: Blood doi: 10.1182/blood-2011-09-381905 – volume: 14 start-page: S1 year: 2013 ident: BFsrep21106_CR13 publication-title: BMC bioinformatics doi: 10.1186/1471-2105-14-S12-S1 – volume: 29 start-page: 2617 year: 2013 ident: BFsrep21106_CR36 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt426 – volume: 26 start-page: 1644 year: 2010 ident: BFsrep21106_CR74 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq241 – volume: 10 start-page: 2800 year: 2014 ident: BFsrep21106_CR50 publication-title: Mol BioSyst. doi: 10.1039/C4MB00353E – volume: 42 start-page: D1070 year: 2014 ident: BFsrep21106_CR51 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkt1023 – volume: 33 start-page: 1290 year: 2005 ident: BFsrep21106_CR9 publication-title: Nucleic Acids Res doi: 10.1093/nar/gki200 – volume: 47 start-page: 939 year: 2008 ident: BFsrep21106_CR58 publication-title: GENE CHROMOSOME CANC doi: 10.1002/gcc.20596 – volume: 7 start-page: e46173 year: 2012 ident: BFsrep21106_CR26 publication-title: PLoS One. doi: 10.1371/journal.pone.0046173 – volume: 37 start-page: D98 year: 2009 ident: BFsrep21106_CR52 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkn714 – volume: 31 start-page: 316 year: 2002 ident: BFsrep21106_CR41 publication-title: Nature Gene doi: 10.1038/ng895 – volume: 8 start-page: 1970 year: 2012 ident: BFsrep21106_CR45 publication-title: Mol Biosyst doi: 10.1039/c2mb00002d – volume: 8 start-page: 282 year: 2013 ident: BFsrep21106_CR31 publication-title: Int J Data Min Bioinform doi: 10.1504/IJDMB.2013.056078 – volume: 282 start-page: 32582 year: 2007 ident: BFsrep21106_CR57 publication-title: J Biol Chem. doi: 10.1074/jbc.M702806200 – volume: 118 start-page: 5550 year: 2011 ident: BFsrep21106_CR64 publication-title: Blood doi: 10.1182/blood-2011-06-361972 – volume: 12 start-page: 1 year: 2010 ident: BFsrep21106_CR16 publication-title: Curr Protoc Bioinformatics. – volume: 68 start-page: 1152 year: 2008 ident: BFsrep21106_CR72 publication-title: Prostate doi: 10.1002/pros.20786 – volume: 9 start-page: e92921 year: 2014 ident: BFsrep21106_CR54 publication-title: PLoS One doi: 10.1371/journal.pone.0092921 – volume: 6 start-page: 857 year: 2006 ident: BFsrep21106_CR29 publication-title: Nat Rev Cancer doi: 10.1038/nrc1997 – volume: 8 start-page: e70204 year: 2013 ident: BFsrep21106_CR43 publication-title: PLoS One doi: 10.1371/journal.pone.0070204 – volume: 6 start-page: 2 year: 2015 ident: BFsrep21106_CR67 publication-title: J Clin Cell Immunol – volume: 309 start-page: 1577 year: 2005 ident: BFsrep21106_CR5 publication-title: Science doi: 10.1126/science.1113329 – volume: 30 start-page: 953 year: 2009 ident: BFsrep21106_CR59 publication-title: Carcinogenesis doi: 10.1093/carcin/bgp094 – volume: 63 start-page: 11 year: 2013 ident: BFsrep21106_CR68 publication-title: CA Cancer J Clin. doi: 10.3322/caac.21166 – reference: 26278472 - Sci Rep. 2015;5:13186 – reference: 12006977 - Nat Genet. 2002 Jul;31(3):316-9 – reference: 18371930 - Am J Hum Genet. 2008 Apr;82(4):949-58 – reference: 16381832 - Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4 – reference: 16969338 - Mol Syst Biol. 2006;2:46 – reference: 19843336 - BMC Cancer. 2009;9:374 – reference: 23503464 - Oncogene. 2014 Mar 13;33(11):1448-57 – reference: 23071542 - PLoS One. 2012;7(10):e46173 – reference: 16680138 - Nat Biotechnol. 2006 May;24(5):537-44 – reference: 19524507 - Cell. 2009 Jun 12;137(6):1032-46 – reference: 22306127 - Lung Cancer. 2012 Jul;77(1):16-23 – reference: 24002109 - Bioinformatics. 2013 Oct 15;29(20):2617-24 – reference: 26061969 - Sci Rep. 2015;5:11338 – reference: 21037258 - Nucleic Acids Res. 2011 Jan;39(Database issue):D152-7 – reference: 17584784 - Nucleic Acids Res. 2007;35(13):4535-41 – reference: 25599923 - Int J Urol. 2015 Mar;22(3):242-52 – reference: 22875290 - Mol Biosyst. 2012 Oct;8(10):2792-8 – reference: 15372042 - Nature. 2004 Sep 16;431(7006):350-5 – reference: 24921248 - PLoS One. 2014;9(6):e96670 – reference: 18048652 - Science. 2007 Dec 21;318(5858):1931-4 – reference: 21768329 - Mol Cancer Ther. 2011 Oct;10(10):1857-66 – reference: 18663744 - Genes Chromosomes Cancer. 2008 Nov;47(11):939-46 – reference: 21296855 - CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90 – reference: 18923704 - PLoS One. 2008;3(10):e3420 – reference: 20726795 - OMICS. 2010 Aug;14(4):337-56 – reference: 11779458 - Cell. 2001 Dec 28;107(7):823-6 – reference: 22538619 - Mol Biosyst. 2012 Jul 6;8(7):1970-8 – reference: 19738047 - Cancer Res. 2009 Sep 15;69(18):7165-9 – reference: 21143814 - BMC Genomics. 2010;11 Suppl 4:S5 – reference: 23335087 - CA Cancer J Clin. 2013 Jan;63(1):11-30 – reference: 21910161 - Genes Chromosomes Cancer. 2011 Nov;50(11):950-67 – reference: 18834855 - Biochem Biophys Res Commun. 2008 Dec 5;377(1):114-9 – reference: 19167326 - Cell. 2009 Jan 23;136(2):215-33 – reference: 16311325 - Science. 2005 Nov 25;310(5752):1288-9 – reference: 26543857 - Biomed Res Int. 2015;2015:350983 – reference: 16099643 - Curr Opin Genet Dev. 2005 Oct;15(5):563-8 – reference: 17616669 - Cancer Res. 2007 Jul 1;67(13):6130-5 – reference: 18927107 - Nucleic Acids Res. 2009 Jan;37(Database issue):D98-104 – reference: 21960592 - Blood. 2011 Nov 17;118(20):5550-8 – reference: 16461460 - Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61 – reference: 17827156 - J Biol Chem. 2007 Nov 9;282(45):32582-90 – reference: 26577439 - Sci Rep. 2015;5:16840 – reference: 16644494 - C R Biol. 2006 Apr;329(4):241-54 – reference: 16141076 - Science. 2005 Sep 2;309(5740):1577-81 – reference: 19372139 - Carcinogenesis. 2009 Jun;30(6):953-9 – reference: 22343918 - Blood. 2012 Apr 12;119(15):3503-11 – reference: 19177201 - Neoplasia. 2009 Feb;11(2):167-76 – reference: 18185580 - Nature. 2008 Jan 10;451(7175):147-52 – reference: 25448984 - FEBS Lett. 2014 Nov 28;588(23):4438-47 – reference: 18063818 - Circ Res. 2007 Dec 7;101(12):1225-36 – reference: 16557279 - Nat Rev Cancer. 2006 Apr;6(4):259-69 – reference: 14744438 - Cell. 2004 Jan 23;116(2):281-97 – reference: 24273243 - Bioinformatics. 2014 Feb 1;30(3):392-7 – reference: 24975600 - Sci Rep. 2014;4:5501 – reference: 17060945 - Nat Rev Cancer. 2006 Nov;6(11):857-66 – reference: 21289068 - Genes Dev. 2011 Feb 1;25(3):226-31 – reference: 24417022 - Int J Data Min Bioinform. 2013;8(3):282-93 – reference: 26347258 - Sci Rep. 2015;5:13877 – reference: 24267745 - BMC Bioinformatics. 2013;14 Suppl 12:S1 – reference: 15522457 - Trends Genet. 2004 Dec;20(12):617-24 – reference: 23950912 - PLoS One. 2013;8(8):e70204 – reference: 15372041 - Nature. 2004 Sep 16;431(7006):343-9 – reference: 24705249 - PLoS One. 2014;9(4):e92921 – reference: 22937049 - PLoS One. 2012;7(8):e43425 – reference: 23480797 - FEBS J. 2013 May;280(9):2105-16 – reference: 24103777 - BMC Syst Biol. 2013;7:101 – reference: 15741182 - Nucleic Acids Res. 2005;33(4):1290-7 – reference: 24194601 - Nucleic Acids Res. 2014 Jan;42(Database issue):D1070-4 – reference: 25099736 - Mol Biosyst. 2014 Nov;10(11):2800-9 – reference: 18459106 - Prostate. 2008 Aug 1;68(11):1152-64 – reference: 20522252 - BMC Syst Biol. 2010;4 Suppl 1:S2 – reference: 20439255 - Bioinformatics. 2010 Jul 1;26(13):1644-50 – reference: 16115313 - BMC Genet. 2005;6:45
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Snippet	Increasing evidences have indicated that microRNAs (miRNAs) are functionally associated with the development and progression of various complex human diseases....
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SubjectTerms	631/114/2397 631/337/384/331 631/553/2695 Algorithms Colon Colorectal cancer Computational Biology - methods Computer applications Disease Genetic Association Studies - methods Genetic Predisposition to Disease Humanities and Social Sciences Humans Lymphoma MicroRNAs - genetics miRNA Molecular modelling multidisciplinary Neoplasms - genetics Prostate Prostate cancer Reproducibility of Results ROC Curve Science Tumors
Title	WBSMDA: Within and Between Score for MiRNA-Disease Association prediction
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