Homogeneous Expansion of Human T-Regulatory Cells Via Tumor Necrosis Factor Receptor 2

T-regulatory cells (T regs ) are a rare lymphocyte subtype that shows promise for treating infectious disease, allergy, graft-versus-host disease, autoimmunity and asthma. Clinical applications of T regs have not been fully realized because standard methods of expansion ex vivo produce heterogeneous...

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Bibliographic Details
Published in:	Scientific reports Vol. 3; no. 1; p. 3153
Main Authors:	Okubo, Yoshiaki, Mera, Toshiyuki, Wang, Limei, Faustman, Denise L.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 06.11.2013 Nature Publishing Group
Subjects:	13 13/1 631/1647/664/1364 631/61/24 692/308/575 Allergies Animals Antibodies, Monoclonal - immunology Asthma Autoimmune diseases Autoimmunity CD4 antigen CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism Cell Proliferation Cell surface Cells, Cultured Clinical trials Cytokines - metabolism Cytotoxicity Forkhead Transcription Factors - metabolism Graft-versus-host reaction Humanities and Social Sciences Humans Immunoregulation Infectious diseases Interleukin-2 - genetics Interleukin-2 - metabolism Interleukin-2 - pharmacology Lymphocytes Lymphocytes T multidisciplinary Necrosis Offspring Receptors, Tumor Necrosis Factor, Type II - agonists Receptors, Tumor Necrosis Factor, Type II - antagonists & inhibitors Receptors, Tumor Necrosis Factor, Type II - metabolism Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Recombinant Proteins - pharmacology Science Surface markers T cell receptors T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - metabolism Therapeutic applications Tumor necrosis factor Tumor necrosis factor receptor 2 Tumor necrosis factor receptors Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-TNF
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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