Neuroinflammation and cognition across psychiatric conditions

Cognitive impairments reported across psychiatric conditions (ie, major depressive disorder, bipolar disorder, schizophrenia, and posttraumatic stress disorder) strongly impair the quality of life of patients and the recovery of those conditions. There is therefore a great need for consideration for...

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Vydáno v:CNS spectrums Ročník 24; číslo 1; s. 4 - 15
Hlavní autoři: Fourrier, Célia, Singhal, Gaurav, Baune, Bernhard T.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Cambridge University Press 01.02.2019
Témata:
Adults
Anti-Inflammatory Agents - therapeutic use
Brain-derived neurotrophic factor
Chemokines
Cognition
Cognition & reasoning
Cognitive ability
Cytokines
Humans
Inflammation
Memory
Mental disorders
Mental Disorders - drug therapy
Mental Disorders - metabolism
Mental Disorders - physiopathology
Neurobiology
Neurogenesis
Physiology
Post traumatic stress disorder
Regulation
Tumor necrosis factor-TNF
Cognition
cross-diagnoses approach
inflammation
cognitive dysfunction
psychiatric disorders
ISSN:1092-8529, 2165-6509
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Shrnutí:Cognitive impairments reported across psychiatric conditions (ie, major depressive disorder, bipolar disorder, schizophrenia, and posttraumatic stress disorder) strongly impair the quality of life of patients and the recovery of those conditions. There is therefore a great need for consideration for cognitive dysfunction in the management of psychiatric disorders. The redundant pattern of cognitive impairments across such conditions suggests possible shared mechanisms potentially leading to their development. Here, we review for the first time the possible role of inflammation in cognitive dysfunctions across psychiatric disorders. Raised inflammatory processes (microglia activation and elevated cytokine levels) across diagnoses could therefore disrupt neurobiological mechanisms regulating cognition, including Hebbian and homeostatic plasticity, neurogenesis, neurotrophic factor, the HPA axis, and the kynurenine pathway. This redundant association between elevated inflammation and cognitive alterations across psychiatric disorders hence suggests that a cross-disorder approach using pharmacological and nonpharmacological (ie, physical activity and nutrition) anti-inflammatory/immunomodulatory strategies should be considered in the management of cognition in psychiatry.
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ISSN:1092-8529
2165-6509
DOI:10.1017/S1092852918001499