New-onset systemic sclerosis and scleroderma renal crisis under docetaxel

Systemic sclerosis is a rare systemic autoimmune disease characterized by microvascular impairment and fibrosis of the skin and other organs with poor outcomes. Toxic causes may be involved. We reported the case of a 59-year-old woman who developed an acute systemic sclerosis after two doses of adju...

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Published in:Journal of scleroderma and related disorders Vol. 6; no. 3; p. 306
Main Authors: Debien, Véronique, Petitdemange, Arthur, Bazin, Dorothée, Ederle, Carole, Nespola, Benoit, Merdji, Hamid, Olagne, Jérome, Martin, Thierry, Guffroy, Aurélien, Pflumio, Carole
Format: Journal Article
Language:English
Published: England 01.10.2021
Subjects:
systemic sclerosis
paraneoplastic
chemotherapy
drug-induced autoimmune disease
scleroderma
Docetaxel
ISSN:2397-1991, 2397-1991
Online Access:Get more information
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Summary:Systemic sclerosis is a rare systemic autoimmune disease characterized by microvascular impairment and fibrosis of the skin and other organs with poor outcomes. Toxic causes may be involved. We reported the case of a 59-year-old woman who developed an acute systemic sclerosis after two doses of adjuvant chemotherapy by docetaxel and cyclophosphamide for a localized hormone receptor + human epithelial receptor 2-breast cancer. Docetaxel is a major chemotherapy drug used in the treatment of breast, lung, and prostate cancers, among others. Scleroderma-like skin-induced changes (morphea) have been already described for taxanes. Here, we report for the first time a case of severe lung and kidney flare with thrombotic microangiopathy after steroids for acute interstitial lung disease probably induced by anti-RNA polymerase III + systemic sclerosis after docetaxel.
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ISSN:2397-1991
2397-1991
DOI:10.1177/23971983211007669