Targeting ATF6 reduces pathological neovascularization and improves visual outcomes in retinal disease models

Pathological retinal neovascularization is a cause of vision loss in diseases including retinopathy of prematurity (ROP), wet age-related macular degeneration (AMD), and diabetic retinopathy. The Unfolded Protein Response (UPR) is an intracellular signal transduction mechanism that is activated by E...

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Veröffentlicht in:	Scientific reports Jg. 15; H. 1; S. 33070 - 15
Hauptverfasser:	Bradley, Allyssa, Park, Soyoung, Park, Soyeon, Kim, Kyle, Galdamez, Angela, Min, Hyejung, Diaz-Aguilar, Monica Sophia, Hartnett, M. Elizabeth, Lee, Eun-Jin, Lin, Jonathan H.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 26.09.2025 Nature Publishing Group Nature Portfolio
Schlagworte:	631/136/16 631/378/2613/1786 692/699/3161/3175 692/699/3161/3175/3188 Activating transcription factor 6 Activating Transcription Factor 6 - antagonists & inhibitors Activating Transcription Factor 6 - genetics Activating Transcription Factor 6 - metabolism Age Angiogenesis Animals Blood vessels Cell Proliferation Diabetes mellitus Disease Models, Animal Endothelial cells Humanities and Social Sciences Hyperoxia Hypoxia Hypoxia-inducible factor 1a Kinases Macular degeneration Mice Mice, Inbred C57BL Mice, Knockout multidisciplinary Physiology Postpartum period Protein folding Proteins Retina Retina - metabolism Retina - pathology Retinal Neovascularization - genetics Retinal Neovascularization - metabolism Retinal Neovascularization - pathology Retinopathy Retinopathy of Prematurity - metabolism Retinopathy of Prematurity - pathology Science Science (multidisciplinary) Signal Transduction Therapeutic targets Unfolded Protein Response - genetics Vascular endothelial growth factor Vascularization Vision Visual perception
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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