Genomic insights into the 2020 mass die-off event among African elephants

Nature Communicationshttps://doi.org/10.1038/s41467-023-41987-z (2023) The article ‘Pasteurella sp. associated with fatal septicaemia in six African elephants’ by Foggin et al.1 shows that the mass die-off event involving 35 elephants in north-western Zimbabwe during the hot dry season (August–Novem...

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Veröffentlicht in:Nature communications Jg. 16; H. 1; S. 8525 - 4
Hauptverfasser: Rasmussen, Astrid, Roer, Louise, Angen, Øystein, Henton, Marijke M., Bisgaard, Magne, Christensen, Henrik, Larsen, Jesper
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 26.09.2025
Nature Publishing Group
Nature Portfolio
Schlagworte:
45/23
631/326/41/2529
631/326/41/2531
Antigens
Biosynthesis
Dry season
Elephants
Genomes
Hemorrhagic septicemia
Humanities and Social Sciences
Hyaluronic acid
Matters Arising
multidisciplinary
Phylogenetics
Polymorphism
Post-transcription
Proteins
Science
Science (multidisciplinary)
Secretion
Sucrose
Toxins
Virulence
ISSN:2041-1723, 2041-1723
Online-Zugang:Volltext
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Zusammenfassung:Nature Communicationshttps://doi.org/10.1038/s41467-023-41987-z (2023) The article ‘Pasteurella sp. associated with fatal septicaemia in six African elephants’ by Foggin et al.1 shows that the mass die-off event involving 35 elephants in north-western Zimbabwe during the hot dry season (August–November) of 2020 was likely due to haemorrhagic septicaemia caused by sucrose-negative Pasteurella multocida-like bacteria belonging to Bisgaard taxon 45. [...]we sequenced eight sucrose-negative capsular serogroup A isolates belonging to P. multocida subsp. multocida (n = 4) and P. multocida subsp. septica (n = 4) and downloaded the genomes of five existing genomes of P. multocida expressing capsular serogroup E, the causative agent of haemorrhagic septicaemia in cattle and buffaloes in Africa8; these isolates were selected because the former share phenotypic traits (unable to utilise sucrose) with Bisgaard taxon 45 and the latter share geographical range with the outbreak strain and cause similar pathological lesions. Phylogenetic analysis showed that the three isolates from elephant VF20/112, the lion isolate, the calf isolate, and the six Bisgaard taxon 45 isolates clustered together, whereas the two cheetah isolates, the sucrose-negative P. multocida subsp. multocida and septica capsular serogroup A isolates, and the P. multocida subsp. multocida capsular serogroup E isolates formed separate clusters within the P. multocida subsp. multocida/gallicida clade (Fig. 1 and Supplementary Data 3). The frpC locus in N. meningitidis contains the frpD gene, which encodes an outer membrane lipoprotein FrpD that binds to the amino-proximal portion of FrpC, whereas it lacks the genes encoding an acyltransferase (rtxC) and the type I secretion system (rtxB and rtxD) that are responsible for posttranscriptional activation and secretion of many RTX proteins, respectively13.
Bibliographie:SourceType-Scholarly Journals-1
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-025-63446-7