Allicin ameliorates doxorubicin-induced cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis

Purpose Doxorubicin (DOX) is a highly active antineoplastic agent; however, its clinical use is limited due to associated cardiotoxicity. This study was performed to evaluate the beneficial effects of allicin, a dietary garlic active constituent against DOX-induced cardiotoxicity. Methods Forty male...

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Bibliographic Details
Published in:	Cancer chemotherapy and pharmacology Vol. 80; no. 4; pp. 745 - 753
Main Authors:	Abdel-Daim, Mohamed M., kilany, Omnia E., Khalifa, Hesham A., Ahmed, Amal A. M.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2017 Springer Nature B.V
Subjects:	Animals Antibiotics, Antineoplastic - toxicity Antioxidants Antioxidants - administration & dosage Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Biomarkers - blood Cancer Research Cardiotoxicity Cardiotoxicity - etiology Cardiotoxicity - prevention & control Caspase Caspase-3 Catalase Creatine Creatine kinase Cyclooxygenase-2 Cytokines Cytokines - metabolism Dose-Response Relationship, Drug Doxorubicin Doxorubicin - toxicity Glutathione peroxidase Heart Heart diseases Inflammation Inflammation - chemically induced Inflammation - prevention & control Intoxication L-Lactate dehydrogenase Lactic acid Male Malondialdehyde Malondialdehyde - metabolism Medicine Medicine & Public Health Mice Nitric oxide Nitric Oxide - metabolism Oncology Original Article Oxidative stress Oxidative Stress - drug effects Pharmacology/Toxicology Rodents Serum levels Sulfinic Acids - administration & dosage Sulfinic Acids - pharmacology Superoxide dismutase Heart Oxidative damage Adriamycin Inflammation Garlic Cardiotoxicity Antioxidant Anti-inflammatory Apoptosis
ISSN:	0344-5704, 1432-0843, 1432-0843
Online Access:	Get full text
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