Allicin ameliorates doxorubicin-induced cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis

Purpose Doxorubicin (DOX) is a highly active antineoplastic agent; however, its clinical use is limited due to associated cardiotoxicity. This study was performed to evaluate the beneficial effects of allicin, a dietary garlic active constituent against DOX-induced cardiotoxicity. Methods Forty male...

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Vydáno v:	Cancer chemotherapy and pharmacology Ročník 80; číslo 4; s. 745 - 753
Hlavní autoři:	Abdel-Daim, Mohamed M., kilany, Omnia E., Khalifa, Hesham A., Ahmed, Amal A. M.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2017 Springer Nature B.V
Témata:	Animals Antibiotics, Antineoplastic - toxicity Antioxidants Antioxidants - administration & dosage Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Biomarkers - blood Cancer Research Cardiotoxicity Cardiotoxicity - etiology Cardiotoxicity - prevention & control Caspase Caspase-3 Catalase Creatine Creatine kinase Cyclooxygenase-2 Cytokines Cytokines - metabolism Dose-Response Relationship, Drug Doxorubicin Doxorubicin - toxicity Glutathione peroxidase Heart Heart diseases Inflammation Inflammation - chemically induced Inflammation - prevention & control Intoxication L-Lactate dehydrogenase Lactic acid Male Malondialdehyde Malondialdehyde - metabolism Medicine Medicine & Public Health Mice Nitric oxide Nitric Oxide - metabolism Oncology Original Article Oxidative stress Oxidative Stress - drug effects Pharmacology/Toxicology Rodents Serum levels Sulfinic Acids - administration & dosage Sulfinic Acids - pharmacology Superoxide dismutase Heart Oxidative damage Adriamycin Inflammation Garlic Cardiotoxicity Antioxidant Anti-inflammatory Apoptosis
ISSN:	0344-5704, 1432-0843, 1432-0843
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Abstract	Purpose Doxorubicin (DOX) is a highly active antineoplastic agent; however, its clinical use is limited due to associated cardiotoxicity. This study was performed to evaluate the beneficial effects of allicin, a dietary garlic active constituent against DOX-induced cardiotoxicity. Methods Forty male Swiss albino mice were divided into five groups, which received normal saline, oral allicin (20 mg kg −1 once daily), intraperitoneal DOX (on the 7, 9 and 11th day of the experiment), or DOX plus once daily allicin at 10 or 20 mg kg −1 . Sera were collected for evaluation of cardiac injury markers and proinflammatory cytokines. Additionally, heart tissue spacemen were harvested for determination of oxidative stress markers, as well as for histopathological examination and immunohistochemical analysis. Results DOX administration induced significant ( p < 0.05) reductions in cardiac tissue level of reduced glutathione and activities of antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase). Moreover, it induced significant ( p < 0.05) elevations in cardiac tissue concentrations of nitric oxide and malondialdehyde as well as serum levels of cardiac injury biomarkers (lactate dehydrogenase, creatine kinase, and creatine kinase-MB) and proinflammatory cytokines (interleukin-1β, and tumor necrosis factor-alpha). The histopathological examination showed necrotic and degenerative changes in the cardiac tissue, while immunohistochemical analysis revealed marked myocardial expression of activated caspase-3 and cyclooxygenase-2, following DOX adminstration. Allicin pretreatment significantly improved ( p < 0.05) all examined parameters, and restored the cardiac architecture. Conclusion The current study demonstrated that allicin effectively mitigates cardiac oxidative damage, apoptosis and inflammation, induced by acute DOX intoxication. Therefore, allicin could be a promising cytoprotective agent against DOX cardiotoxicity.
AbstractList	Doxorubicin (DOX) is a highly active antineoplastic agent; however, its clinical use is limited due to associated cardiotoxicity. This study was performed to evaluate the beneficial effects of allicin, a dietary garlic active constituent against DOX-induced cardiotoxicity.PURPOSEDoxorubicin (DOX) is a highly active antineoplastic agent; however, its clinical use is limited due to associated cardiotoxicity. This study was performed to evaluate the beneficial effects of allicin, a dietary garlic active constituent against DOX-induced cardiotoxicity.Forty male Swiss albino mice were divided into five groups, which received normal saline, oral allicin (20 mg kg-1 once daily), intraperitoneal DOX (on the 7, 9 and 11th day of the experiment), or DOX plus once daily allicin at 10 or 20 mg kg-1. Sera were collected for evaluation of cardiac injury markers and proinflammatory cytokines. Additionally, heart tissue spacemen were harvested for determination of oxidative stress markers, as well as for histopathological examination and immunohistochemical analysis.METHODSForty male Swiss albino mice were divided into five groups, which received normal saline, oral allicin (20 mg kg-1 once daily), intraperitoneal DOX (on the 7, 9 and 11th day of the experiment), or DOX plus once daily allicin at 10 or 20 mg kg-1. Sera were collected for evaluation of cardiac injury markers and proinflammatory cytokines. Additionally, heart tissue spacemen were harvested for determination of oxidative stress markers, as well as for histopathological examination and immunohistochemical analysis.DOX administration induced significant (p < 0.05) reductions in cardiac tissue level of reduced glutathione and activities of antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase). Moreover, it induced significant (p < 0.05) elevations in cardiac tissue concentrations of nitric oxide and malondialdehyde as well as serum levels of cardiac injury biomarkers (lactate dehydrogenase, creatine kinase, and creatine kinase-MB) and proinflammatory cytokines (interleukin-1β, and tumor necrosis factor-alpha). The histopathological examination showed necrotic and degenerative changes in the cardiac tissue, while immunohistochemical analysis revealed marked myocardial expression of activated caspase-3 and cyclooxygenase-2, following DOX adminstration. Allicin pretreatment significantly improved (p < 0.05) all examined parameters, and restored the cardiac architecture.RESULTSDOX administration induced significant (p < 0.05) reductions in cardiac tissue level of reduced glutathione and activities of antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase). Moreover, it induced significant (p < 0.05) elevations in cardiac tissue concentrations of nitric oxide and malondialdehyde as well as serum levels of cardiac injury biomarkers (lactate dehydrogenase, creatine kinase, and creatine kinase-MB) and proinflammatory cytokines (interleukin-1β, and tumor necrosis factor-alpha). The histopathological examination showed necrotic and degenerative changes in the cardiac tissue, while immunohistochemical analysis revealed marked myocardial expression of activated caspase-3 and cyclooxygenase-2, following DOX adminstration. Allicin pretreatment significantly improved (p < 0.05) all examined parameters, and restored the cardiac architecture.The current study demonstrated that allicin effectively mitigates cardiac oxidative damage, apoptosis and inflammation, induced by acute DOX intoxication. Therefore, allicin could be a promising cytoprotective agent against DOX cardiotoxicity.CONCLUSIONThe current study demonstrated that allicin effectively mitigates cardiac oxidative damage, apoptosis and inflammation, induced by acute DOX intoxication. Therefore, allicin could be a promising cytoprotective agent against DOX cardiotoxicity. Doxorubicin (DOX) is a highly active antineoplastic agent; however, its clinical use is limited due to associated cardiotoxicity. This study was performed to evaluate the beneficial effects of allicin, a dietary garlic active constituent against DOX-induced cardiotoxicity. Forty male Swiss albino mice were divided into five groups, which received normal saline, oral allicin (20 mg kg once daily), intraperitoneal DOX (on the 7, 9 and 11th day of the experiment), or DOX plus once daily allicin at 10 or 20 mg kg . Sera were collected for evaluation of cardiac injury markers and proinflammatory cytokines. Additionally, heart tissue spacemen were harvested for determination of oxidative stress markers, as well as for histopathological examination and immunohistochemical analysis. DOX administration induced significant (p < 0.05) reductions in cardiac tissue level of reduced glutathione and activities of antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase). Moreover, it induced significant (p < 0.05) elevations in cardiac tissue concentrations of nitric oxide and malondialdehyde as well as serum levels of cardiac injury biomarkers (lactate dehydrogenase, creatine kinase, and creatine kinase-MB) and proinflammatory cytokines (interleukin-1β, and tumor necrosis factor-alpha). The histopathological examination showed necrotic and degenerative changes in the cardiac tissue, while immunohistochemical analysis revealed marked myocardial expression of activated caspase-3 and cyclooxygenase-2, following DOX adminstration. Allicin pretreatment significantly improved (p < 0.05) all examined parameters, and restored the cardiac architecture. The current study demonstrated that allicin effectively mitigates cardiac oxidative damage, apoptosis and inflammation, induced by acute DOX intoxication. Therefore, allicin could be a promising cytoprotective agent against DOX cardiotoxicity. Doxorubicin (DOX) is a highly active antineoplastic agent; however, its clinical use is limited due to associated cardiotoxicity. This study was performed to evaluate the beneficial effects of allicin, a dietary garlic active constituent against DOX-induced cardiotoxicity. Forty male Swiss albino mice were divided into five groups, which received normal saline, oral allicin (20 mg kg−1 once daily), intraperitoneal DOX (on the 7, 9 and 11th day of the experiment), or DOX plus once daily allicin at 10 or 20 mg kg−1. Sera were collected for evaluation of cardiac injury markers and proinflammatory cytokines. Additionally, heart tissue spacemen were harvested for determination of oxidative stress markers, as well as for histopathological examination and immunohistochemical analysis. DOX administration induced significant (p < 0.05) reductions in cardiac tissue level of reduced glutathione and activities of antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase). Moreover, it induced significant (p < 0.05) elevations in cardiac tissue concentrations of nitric oxide and malondialdehyde as well as serum levels of cardiac injury biomarkers (lactate dehydrogenase, creatine kinase, and creatine kinase-MB) and proinflammatory cytokines (interleukin-1β, and tumor necrosis factor-alpha). The histopathological examination showed necrotic and degenerative changes in the cardiac tissue, while immunohistochemical analysis revealed marked myocardial expression of activated caspase-3 and cyclooxygenase-2, following DOX adminstration. Allicin pretreatment significantly improved (p < 0.05) all examined parameters, and restored the cardiac architecture. The current study demonstrated that allicin effectively mitigates cardiac oxidative damage, apoptosis and inflammation, induced by acute DOX intoxication. Therefore, allicin could be a promising cytoprotective agent against DOX cardiotoxicity. Purpose Doxorubicin (DOX) is a highly active antineoplastic agent; however, its clinical use is limited due to associated cardiotoxicity. This study was performed to evaluate the beneficial effects of allicin, a dietary garlic active constituent against DOX-induced cardiotoxicity. Methods Forty male Swiss albino mice were divided into five groups, which received normal saline, oral allicin (20 mg kg −1 once daily), intraperitoneal DOX (on the 7, 9 and 11th day of the experiment), or DOX plus once daily allicin at 10 or 20 mg kg −1 . Sera were collected for evaluation of cardiac injury markers and proinflammatory cytokines. Additionally, heart tissue spacemen were harvested for determination of oxidative stress markers, as well as for histopathological examination and immunohistochemical analysis. Results DOX administration induced significant ( p < 0.05) reductions in cardiac tissue level of reduced glutathione and activities of antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase). Moreover, it induced significant ( p < 0.05) elevations in cardiac tissue concentrations of nitric oxide and malondialdehyde as well as serum levels of cardiac injury biomarkers (lactate dehydrogenase, creatine kinase, and creatine kinase-MB) and proinflammatory cytokines (interleukin-1β, and tumor necrosis factor-alpha). The histopathological examination showed necrotic and degenerative changes in the cardiac tissue, while immunohistochemical analysis revealed marked myocardial expression of activated caspase-3 and cyclooxygenase-2, following DOX adminstration. Allicin pretreatment significantly improved ( p < 0.05) all examined parameters, and restored the cardiac architecture. Conclusion The current study demonstrated that allicin effectively mitigates cardiac oxidative damage, apoptosis and inflammation, induced by acute DOX intoxication. Therefore, allicin could be a promising cytoprotective agent against DOX cardiotoxicity.
Author	Ahmed, Amal A. M. Abdel-Daim, Mohamed M. kilany, Omnia E. Khalifa, Hesham A.
Author_xml	– sequence: 1 givenname: Mohamed M. orcidid: 0000-0002-4341-2713 surname: Abdel-Daim fullname: Abdel-Daim, Mohamed M. email: abdeldaim.m@vet.suez.edu.eg, abdeldaim.m@gmail.com organization: Department of Pharmacology, Faculty of Veterinary Medicine, Suez Canal University – sequence: 2 givenname: Omnia E. surname: kilany fullname: kilany, Omnia E. organization: Department of Clinical Pathology, Faculty of Veterinary Medicine, Suez Canal University – sequence: 3 givenname: Hesham A. surname: Khalifa fullname: Khalifa, Hesham A. organization: Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University – sequence: 4 givenname: Amal A. M. surname: Ahmed fullname: Ahmed, Amal A. M. organization: Cytology and Histology Department, Faculty of Veterinary Medicine, Suez Canal University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28785995$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1152/ajpheart.00844.2011 10.1039/c3fo60057b 10.1016/j.cbi.2005.07.008 10.1007/BF01469790 10.1016/S0076-6879(84)05016-3 10.1089/jmf.2009.0162 10.1016/j.taap.2016.01.006 10.3109/13880209.2013.876053 10.1016/S0014-2999(01)00765-8 10.1007/s11010-005-9003-8 10.1016/j.intimp.2015.09.010 10.1016/S0167-4889(00)00119-1 10.1016/j.bbrc.2008.06.067 10.1016/j.jep.2008.01.022 10.1016/S0899-9007(02)00916-4 10.1345/aph.1L319 10.1016/S0006-291X(72)80218-3 10.1016/S0891-5849(99)00176-8 10.1152/ajpheart.00384.2006 10.1016/0024-3205(81)90001-1 10.4161/cbt.22628 10.1016/j.biomaterials.2008.04.048 10.1152/ajpheart.01249.2004 10.1111/j.1471-4159.2006.04179.x 10.3109/13880209.2013.766895 10.1016/j.biopha.2017.04.033 10.1179/1351000214Y.0000000088 10.1016/S0304-4165(97)00104-9 10.1016/S0005-2728(97)00055-8 10.1016/j.yjmcc.2012.03.006 10.1161/CIRCULATIONAHA.115.017443 10.1161/CIRCRESAHA.113.300218 10.1016/j.pcad.2006.10.002 10.1016/j.tox.2005.10.015 10.3109/00498254.2015.1034223 10.1093/ajcp/28.1.56 10.1016/0021-9150(77)90092-2 10.1007/s10565-006-0140-y 10.1016/j.bmc.2004.10.066 10.1016/j.jnutbio.2009.11.001 10.1016/j.toxlet.2009.01.025 10.1016/0003-2697(78)90342-1 10.1016/0003-2697(82)90118-X 10.3390/molecules16108601 10.1007/BF00928155 10.1016/j.abb.2004.08.001 10.1006/jmcc.1999.0972 10.3109/09637486.2014.925428 10.1016/0009-8981(73)90381-1 10.1039/b611506c 10.1016/j.ecoenv.2014.10.019 10.1093/clinchem/25.3.446
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Copyright	Springer-Verlag GmbH Germany 2017 Cancer Chemotherapy and Pharmacology is a copyright of Springer, 2017.
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Keywords	Heart Oxidative damage Adriamycin Inflammation Garlic Cardiotoxicity Antioxidant Anti-inflammatory Apoptosis
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PublicationDate	2017-10-01
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PublicationPlace	Berlin/Heidelberg
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PublicationTitle	Cancer chemotherapy and pharmacology
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PublicationYear	2017
Publisher	Springer Berlin Heidelberg Springer Nature B.V
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References	Yilmaz, Atessahin, Sahna, Karahan, Ozer (CR42) 2006; 218 Chan, Tsui, Chung, Chan, Kwan (CR16) 2014; 65 Wang, Wang, Zhang, Li, Yue (CR40) 2007; 32 Rabinkov, Miron, Konstantinovski, Wilchek, Mirelman (CR45) 1998; 1379 Ky, Vejpongsa, Yeh, Force, Moslehi (CR7) 2013; 113 Sun, Ku (CR14) 2006; 291 Olson, Boerth, Gerber, Nies (CR4) 1981; 29 Oz, Ilhan (CR8) 2006; 286 Aebi (CR26) 1984; 105 Boucek, Miracle, Anderson, Engelman, Atkinson (CR54) 1999; 31 Rabinkov, Miron, Mirelman, Wilchek, Glozman (CR44) 2000; 1499 Waring (CR58) 2005; 434 Chatterjee, Zhang, Tao, Honbo, Karliner (CR51) 2008; 373 Liu, Cao, Tang, Yan, Dong (CR50) 2010; 21 Bordia, Verma, Vyas, Khabya, Rathore (CR11) 1977; 26 Green, Wagner, Glogowski, Skipper, Wishnok (CR31) 1982; 126 Abushouk, Ismail, Salem, Afifi, Abdel-Daim (CR10) 2017; 90 Reinhart, Coleman, Teevan, Vachhani, White (CR12) 2008; 42 Reitman, Frankel (CR22) 1957; 28 De Beer, Bottone, Voest (CR33) 2001; 415 Wurzburg, Hennrich, Lang, Prellwitz, Neumeier (CR25) 1976; 54 Okada, Tanaka, Sato, Okajima (CR49) 2006; 4 Babson, Babson (CR23) 1973; 44 Zhou, Starkov, Froberg, Leino, Wallace (CR34) 2001; 61 Wong, Smith, Magun, Engstrom, Kelley-Howard (CR47) 2013; 14 Li, Wang, Ding, Tan, Luo (CR6) 2016; 133 Singh, Singh, Abraham, Bhat, Mukherjee (CR55) 2008; 117 Raskovic, Stilinovic, Kolarovic, Vasovic, Vukmirovic (CR38) 2011; 16 Injac, Perse, Obermajer, Djordjevic-Milic, Prijatelj (CR1) 2008; 29 Ashry, Gameil, Suddek (CR20) 2013; 51 Ascensao, Magalhaes, Soares, Ferreira, Neuparth (CR35) 2005; 289 Paglia, Valentine (CR28) 1967; 70 Hou, Jiang, Wang, Xu, Lin (CR39) 2009; 187 Nishikimi, Appaji, Yagi (CR27) 1972; 46 Deepa, Varalakshmi (CR9) 2005; 156 Beutler, Duron, Kelly (CR29) 1963; 61 Palmeira, Serrano, Kuehl, Wallace (CR43) 1997; 1321 Takemura, Fujiwara (CR56) 2007; 49 Aniss, Said Ael, El Sayed, Adly (CR41) 2014; 19 Zhang, Wang, Chen, Yan, Yuan (CR17) 2013; 4 Davitashvili, Museridze, Svanidze, Gegenava, Sanikidze (CR57) 2009; 177 Prasad, Laxdal, Yu, Raney (CR46) 1995; 148 Yalçin, Oruç, Çavuşoğlu, Yapar (CR53) 2010; 13 Suddek (CR15) 2014; 52 Elkayam, Peleg, Grossman, Shabtay, Sharabi (CR13) 2013; 15 Shi, Zhang, Zhang, Surma, Payne (CR52) 2012; 302 Hao, Yu, Gu, Xing, Xue (CR3) 2015; 45 El-Kashef, El-Kenawi, Suddek, Salem (CR18) 2015; 29 Pecoraro, Del Pizzo, Marzocco, Sorrentino, Ciccarelli (CR21) 2016; 293 Fang, Yang, Wu (CR36) 2002; 18 Abdel-Daim, Abdelkhalek, Hassan (CR19) 2015; 111 Griffith (CR37) 1999; 27 Szasz, Waldenstrom, Gruber (CR24) 1979; 25 Berthiaume, Wallace (CR2) 2007; 23 Mihara, Uchiyama (CR30) 1978; 86 Octavia, Tocchetti, Gabrielson, Janssens, Crijns (CR5) 2012; 52 Ahmed, Mannaa, Elmegeed, Doss (CR32) 2005; 13 Tangpong, Cole, Sultana, Estus, Vore (CR48) 2007; 100 L Zhang (3413_CR17) 2013; 4 MM Abdel-Daim (3413_CR19) 2015; 111 HH Ahmed (3413_CR32) 2005; 13 S Yilmaz (3413_CR42) 2006; 218 XW Hou (3413_CR39) 2009; 187 M Mihara (3413_CR30) 1978; 86 LC Green (3413_CR31) 1982; 126 RJ Boucek Jr (3413_CR54) 1999; 31 SR Babson (3413_CR23) 1973; 44 D Davitashvili (3413_CR57) 2009; 177 G Szasz (3413_CR24) 1979; 25 KM Reinhart (3413_CR12) 2008; 42 J Shi (3413_CR52) 2012; 302 NA Ashry (3413_CR20) 2013; 51 DH El-Kashef (3413_CR18) 2015; 29 DE Paglia (3413_CR28) 1967; 70 A Bordia (3413_CR11) 1977; 26 J Tangpong (3413_CR48) 2007; 100 EL Beer De (3413_CR33) 2001; 415 JM Berthiaume (3413_CR2) 2007; 23 HA Aniss (3413_CR41) 2014; 19 U Wurzburg (3413_CR25) 1976; 54 OW Griffith (3413_CR37) 1999; 27 G Singh (3413_CR55) 2008; 117 A Elkayam (3413_CR13) 2013; 15 RD Olson (3413_CR4) 1981; 29 DL Li (3413_CR6) 2016; 133 Y Okada (3413_CR49) 2006; 4 AI Abushouk (3413_CR10) 2017; 90 GM Suddek (3413_CR15) 2014; 52 K Prasad (3413_CR46) 1995; 148 GY Wang (3413_CR40) 2007; 32 E Yalçin (3413_CR53) 2010; 13 M Nishikimi (3413_CR27) 1972; 46 S Reitman (3413_CR22) 1957; 28 JY Chan (3413_CR16) 2014; 65 E Beutler (3413_CR29) 1963; 61 M Pecoraro (3413_CR21) 2016; 293 J Wong (3413_CR47) 2013; 14 A Raskovic (3413_CR38) 2011; 16 B Ky (3413_CR7) 2013; 113 R Injac (3413_CR1) 2008; 29 Y Octavia (3413_CR5) 2012; 52 A Ascensao (3413_CR35) 2005; 289 CM Palmeira (3413_CR43) 1997; 1321 A Rabinkov (3413_CR45) 1998; 1379 K Chatterjee (3413_CR51) 2008; 373 PR Deepa (3413_CR9) 2005; 156 C Liu (3413_CR50) 2010; 21 S Zhou (3413_CR34) 2001; 61 E Oz (3413_CR8) 2006; 286 YZ Fang (3413_CR36) 2002; 18 G Takemura (3413_CR56) 2007; 49 X Sun (3413_CR14) 2006; 291 G Hao (3413_CR3) 2015; 45 P Waring (3413_CR58) 2005; 434 H Aebi (3413_CR26) 1984; 105 A Rabinkov (3413_CR44) 2000; 1499
References_xml	– volume: 302 start-page: H1603 year: 2012 end-page: H1613 ident: CR52 article-title: Downregulation of doxorubicin-induced myocardial apoptosis accompanies postnatal heart maturation publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00844.2011 – volume: 4 start-page: 1229 year: 2013 end-page: 1236 ident: CR17 article-title: Potential protective effects of oral administration of allicin on acrylamide-induced toxicity in male mice publication-title: Food Funct doi: 10.1039/c3fo60057b – volume: 156 start-page: 93 year: 2005 end-page: 100 ident: CR9 article-title: Biochemical evaluation of the inflammatory changes in cardiac, hepatic and renal tissues of adriamycin-administered rats and the modulatory role of exogenous heparin-derivative treatment publication-title: Chem Biol Interact doi: 10.1016/j.cbi.2005.07.008 – volume: 54 start-page: 357 year: 1976 end-page: 360 ident: CR25 article-title: Determination of creatine kinase-MB in serum using inhibiting antibodies (author’s transl) publication-title: Klin Wochenschr doi: 10.1007/BF01469790 – volume: 105 start-page: 121 year: 1984 end-page: 126 ident: CR26 article-title: Catalase in vitro publication-title: Methods Enzymol doi: 10.1016/S0076-6879(84)05016-3 – volume: 13 start-page: 917 year: 2010 end-page: 925 ident: CR53 article-title: Protective role of grape seed extract against doxorubicin-induced cardiotoxicity and genotoxicity in albino mice publication-title: J Med Food doi: 10.1089/jmf.2009.0162 – volume: 293 start-page: 44 year: 2016 end-page: 52 ident: CR21 article-title: Inflammatory mediators in a short-time mouse model of doxorubicin-induced cardiotoxicity publication-title: Toxicol Appl Pharmacol doi: 10.1016/j.taap.2016.01.006 – volume: 52 start-page: 1009 year: 2014 end-page: 1014 ident: CR15 article-title: Allicin enhances chemotherapeutic response and ameliorates tamoxifen-induced liver injury in experimental animals publication-title: Pharm Biol doi: 10.3109/13880209.2013.876053 – volume: 415 start-page: 1 year: 2001 end-page: 11 ident: CR33 article-title: Doxorubicin and mechanical performance of cardiac trabeculae after acute and chronic treatment: a review publication-title: Eur J Pharmacol doi: 10.1016/S0014-2999(01)00765-8 – volume: 286 start-page: 11 year: 2006 end-page: 15 ident: CR8 article-title: Effects of melatonin in reducing the toxic effects of doxorubicin publication-title: Mol Cell Biochem doi: 10.1007/s11010-005-9003-8 – volume: 29 start-page: 679 year: 2015 end-page: 686 ident: CR18 article-title: Protective effect of allicin against gentamicin-induced nephrotoxicity in rats publication-title: Int Immunopharmacol doi: 10.1016/j.intimp.2015.09.010 – volume: 1499 start-page: 144 year: 2000 end-page: 153 ident: CR44 article-title: S-Allylmercaptoglutathione: the reaction product of allicin with glutathione possesses SH-modifying and antioxidant properties publication-title: Biochim Biophys Acta doi: 10.1016/S0167-4889(00)00119-1 – volume: 373 start-page: 555 year: 2008 end-page: 560 ident: CR51 article-title: Vincristine attenuates doxorubicin cardiotoxicity publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2008.06.067 – volume: 117 start-page: 123 year: 2008 end-page: 129 ident: CR55 article-title: Protective effects of against doxorubicin-induced cardiotoxicity publication-title: J Ethnopharmacol doi: 10.1016/j.jep.2008.01.022 – volume: 25 start-page: 446 year: 1979 end-page: 452 ident: CR24 article-title: Creatine kinase in serum: 6. Inhibition by endogenous polyvalent cations, and effect of chelators on the activity and stability of some assay components publication-title: Clin Chem – volume: 18 start-page: 872 year: 2002 end-page: 879 ident: CR36 article-title: Free radicals, antioxidants, and nutrition publication-title: Nutrition doi: 10.1016/S0899-9007(02)00916-4 – volume: 42 start-page: 1766 year: 2008 end-page: 1771 ident: CR12 article-title: Effects of garlic on blood pressure in patients with and without systolic hypertension: a meta-analysis publication-title: Ann Pharmacother doi: 10.1345/aph.1L319 – volume: 46 start-page: 849 year: 1972 end-page: 854 ident: CR27 article-title: The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen publication-title: Biochem Biophys Res Commun doi: 10.1016/S0006-291X(72)80218-3 – volume: 27 start-page: 922 year: 1999 end-page: 935 ident: CR37 article-title: Biologic and pharmacologic regulation of mammalian glutathione synthesis publication-title: Free Radic Biol Med doi: 10.1016/S0891-5849(99)00176-8 – volume: 291 start-page: H2431 year: 2006 end-page: H2438 ident: CR14 article-title: Allicin in garlic protects against coronary endothelial dysfunction and right heart hypertrophy in pulmonary hypertensive rats publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00384.2006 – volume: 29 start-page: 1393 year: 1981 end-page: 1401 ident: CR4 article-title: Mechanism of adriamycin cardiotoxicity: evidence for oxidative stress publication-title: Life Sci doi: 10.1016/0024-3205(81)90001-1 – volume: 14 start-page: 56 year: 2013 end-page: 63 ident: CR47 article-title: Small molecule kinase inhibitors block the ZAK-dependent inflammatory effects of doxorubicin publication-title: Cancer Biol Ther doi: 10.4161/cbt.22628 – volume: 29 start-page: 3451 year: 2008 end-page: 3460 ident: CR1 article-title: Potential hepatoprotective effects of fullerenol C60(OH)24 in doxorubicin-induced hepatotoxicity in rats with mammary carcinomas publication-title: Biomaterials doi: 10.1016/j.biomaterials.2008.04.048 – volume: 289 start-page: H722 year: 2005 end-page: H731 ident: CR35 article-title: Moderate endurance training prevents doxorubicin-induced in vivo mitochondriopathy and reduces the development of cardiac apoptosis publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.01249.2004 – volume: 100 start-page: 191 year: 2007 end-page: 201 ident: CR48 article-title: Adriamycin-mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain publication-title: J Neurochem doi: 10.1111/j.1471-4159.2006.04179.x – volume: 51 start-page: 806 year: 2013 end-page: 811 ident: CR20 article-title: Modulation of cyclophosphamide-induced early lung injury by allicin publication-title: Pharm Biol doi: 10.3109/13880209.2013.766895 – volume: 90 start-page: 935 year: 2017 end-page: 946 ident: CR10 article-title: Cardioprotective mechanisms of phytochemicals against doxorubicin-induced cardiotoxicity publication-title: Biomed Pharmacother doi: 10.1016/j.biopha.2017.04.033 – volume: 19 start-page: 170 year: 2014 end-page: 178 ident: CR41 article-title: Amelioration of adriamycin-induced cardiotoxicity by aqueous extract is mediated by lowering oxidative stress publication-title: Redox Rep doi: 10.1179/1351000214Y.0000000088 – volume: 70 start-page: 158 year: 1967 end-page: 169 ident: CR28 article-title: Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase publication-title: J Lab Clin Med – volume: 1379 start-page: 233 year: 1998 end-page: 244 ident: CR45 article-title: The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins publication-title: Biochim Biophys Acta doi: 10.1016/S0304-4165(97)00104-9 – volume: 1321 start-page: 101 year: 1997 end-page: 106 ident: CR43 article-title: Preferential oxidation of cardiac mitochondrial DNA following acute intoxication with doxorubicin publication-title: Biochim Biophys Acta doi: 10.1016/S0005-2728(97)00055-8 – volume: 52 start-page: 1213 year: 2012 end-page: 1225 ident: CR5 article-title: Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies publication-title: J Mol Cell Cardiol doi: 10.1016/j.yjmcc.2012.03.006 – volume: 133 start-page: 1668 year: 2016 end-page: 1687 ident: CR6 article-title: Doxorubicin blocks cardiomyocyte autophagic flux by inhibiting lysosome acidification publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.115.017443 – volume: 113 start-page: 754 year: 2013 end-page: 764 ident: CR7 article-title: Emerging paradigms in cardiomyopathies associated with cancer therapies publication-title: Circ Res doi: 10.1161/CIRCRESAHA.113.300218 – volume: 49 start-page: 330 year: 2007 end-page: 352 ident: CR56 article-title: Doxorubicin-induced cardiomyopathy: from the cardiotoxic mechanisms to management publication-title: Prog Cardiovasc Dis doi: 10.1016/j.pcad.2006.10.002 – volume: 218 start-page: 164 year: 2006 end-page: 171 ident: CR42 article-title: Protective effect of lycopene on adriamycin-induced cardiotoxicity and nephrotoxicity publication-title: Toxicology doi: 10.1016/j.tox.2005.10.015 – volume: 45 start-page: 1024 issue: 11 year: 2015 end-page: 1029 ident: CR3 article-title: Protective effects of berberine against doxorubicin-induced cardiotoxicity in rats by inhibiting metabolism of doxorubicin publication-title: Xenobiotica doi: 10.3109/00498254.2015.1034223 – volume: 177 start-page: 73 year: 2009 end-page: 77 ident: CR57 article-title: Investigation of oxidative stress-induced alterations in the rat brain cortical cellular culture and their correction with vitamins E and C publication-title: Georgian Med News – volume: 28 start-page: 56 year: 1957 end-page: 63 ident: CR22 article-title: A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases publication-title: Am J Clin Pathol doi: 10.1093/ajcp/28.1.56 – volume: 26 start-page: 379 year: 1977 end-page: 386 ident: CR11 article-title: Effect of essential oil of onion and garlic on experimental atherosclerosis in rabbits publication-title: Atherosclerosis doi: 10.1016/0021-9150(77)90092-2 – volume: 23 start-page: 15 year: 2007 end-page: 25 ident: CR2 article-title: Adriamycin-induced oxidative mitochondrial cardiotoxicity publication-title: Cell Biol Toxicol doi: 10.1007/s10565-006-0140-y – volume: 61 start-page: 771 year: 2001 end-page: 777 ident: CR34 article-title: Cumulative and irreversible cardiac mitochondrial dysfunction induced by doxorubicin publication-title: Cancer Res – volume: 13 start-page: 1847 year: 2005 end-page: 1857 ident: CR32 article-title: Cardioprotective activity of melatonin and its novel synthesized derivatives on doxorubicin-induced cardiotoxicity publication-title: Bioorg Med Chem doi: 10.1016/j.bmc.2004.10.066 – volume: 21 start-page: 1238 year: 2010 end-page: 1250 ident: CR50 article-title: Allicin protects against cardiac hypertrophy and fibrosis via attenuating reactive oxygen species-dependent signaling pathways publication-title: J Nutr Biochem doi: 10.1016/j.jnutbio.2009.11.001 – volume: 187 start-page: 40 year: 2009 end-page: 44 ident: CR39 article-title: Protective role of granulocyte colony-stimulating factor against adriamycin induced cardiac, renal and hepatic toxicities publication-title: Toxicol Lett doi: 10.1016/j.toxlet.2009.01.025 – volume: 15 start-page: 170 year: 2013 end-page: 173 ident: CR13 article-title: Effects of allicin on cardiovascular risk factors in spontaneously hypertensive rats publication-title: Isr Med Assoc J – volume: 86 start-page: 271 year: 1978 end-page: 278 ident: CR30 article-title: Determination of malonaldehyde precursor in tissues by thiobarbituric acid test publication-title: Anal Biochem doi: 10.1016/0003-2697(78)90342-1 – volume: 32 start-page: 1563 year: 2007 end-page: 1565 ident: CR40 article-title: Effect of resveratrol on heart function of rats with adriamycin-induced heart failure publication-title: Zhongguo Zhong Yao Za Zhi – volume: 126 start-page: 131 year: 1982 end-page: 138 ident: CR31 article-title: Analysis of nitrate, nitrite, and [15 N] nitrate in biological fluids publication-title: Anal Biochem doi: 10.1016/0003-2697(82)90118-X – volume: 16 start-page: 8601 year: 2011 end-page: 8613 ident: CR38 article-title: The protective effects of silymarin against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats publication-title: Molecules doi: 10.3390/molecules16108601 – volume: 148 start-page: 183 year: 1995 end-page: 189 ident: CR46 article-title: Antioxidant activity of allicin, an active principle in garlic publication-title: Mol Cell Biochem doi: 10.1007/BF00928155 – volume: 434 start-page: 33 year: 2005 end-page: 42 ident: CR58 article-title: Redox active calcium ion channels and cell death publication-title: Arch Biochem Biophys doi: 10.1016/j.abb.2004.08.001 – volume: 31 start-page: 1435 year: 1999 end-page: 1446 ident: CR54 article-title: Persistent effects of doxorubicin on cardiac gene expression publication-title: J Mol Cell Cardiol doi: 10.1006/jmcc.1999.0972 – volume: 65 start-page: 868 year: 2014 end-page: 873 ident: CR16 article-title: Allicin protects rat cardiomyoblasts (H9c2 cells) from hydrogen peroxide-induced oxidative injury through inhibiting the generation of intracellular reactive oxygen species publication-title: Int J Food Sci Nutr doi: 10.3109/09637486.2014.925428 – volume: 44 start-page: 193 year: 1973 end-page: 197 ident: CR23 article-title: An improved amylase assay using dyed amylopectin publication-title: Clin Chim Acta doi: 10.1016/0009-8981(73)90381-1 – volume: 4 start-page: 4113 year: 2006 end-page: 4117 ident: CR49 article-title: Kinetic and mechanistic studies of allicin as an antioxidant publication-title: Org Biomol Chem doi: 10.1039/b611506c – volume: 61 start-page: 882 year: 1963 end-page: 888 ident: CR29 article-title: Improved method for the determination of blood glutathione publication-title: J Lab Clin Med – volume: 111 start-page: 146 year: 2015 end-page: 152 ident: CR19 article-title: Antagonistic activity of dietary allicin against deltamethrin-induced oxidative damage in freshwater Nile tilapia; publication-title: Ecotoxicol Environ Saf doi: 10.1016/j.ecoenv.2014.10.019 – volume: 52 start-page: 1213 year: 2012 ident: 3413_CR5 publication-title: J Mol Cell Cardiol doi: 10.1016/j.yjmcc.2012.03.006 – volume: 1321 start-page: 101 year: 1997 ident: 3413_CR43 publication-title: Biochim Biophys Acta doi: 10.1016/S0005-2728(97)00055-8 – volume: 31 start-page: 1435 year: 1999 ident: 3413_CR54 publication-title: J Mol Cell Cardiol doi: 10.1006/jmcc.1999.0972 – volume: 177 start-page: 73 year: 2009 ident: 3413_CR57 publication-title: Georgian Med News – volume: 291 start-page: H2431 year: 2006 ident: 3413_CR14 publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00384.2006 – volume: 28 start-page: 56 year: 1957 ident: 3413_CR22 publication-title: Am J Clin Pathol doi: 10.1093/ajcp/28.1.56 – volume: 16 start-page: 8601 year: 2011 ident: 3413_CR38 publication-title: Molecules doi: 10.3390/molecules16108601 – volume: 293 start-page: 44 year: 2016 ident: 3413_CR21 publication-title: Toxicol Appl Pharmacol doi: 10.1016/j.taap.2016.01.006 – volume: 1499 start-page: 144 year: 2000 ident: 3413_CR44 publication-title: Biochim Biophys Acta doi: 10.1016/S0167-4889(00)00119-1 – volume: 29 start-page: 1393 year: 1981 ident: 3413_CR4 publication-title: Life Sci doi: 10.1016/0024-3205(81)90001-1 – volume: 54 start-page: 357 year: 1976 ident: 3413_CR25 publication-title: Klin Wochenschr doi: 10.1007/BF01469790 – volume: 61 start-page: 771 year: 2001 ident: 3413_CR34 publication-title: Cancer Res – volume: 156 start-page: 93 year: 2005 ident: 3413_CR9 publication-title: Chem Biol Interact doi: 10.1016/j.cbi.2005.07.008 – volume: 100 start-page: 191 year: 2007 ident: 3413_CR48 publication-title: J Neurochem doi: 10.1111/j.1471-4159.2006.04179.x – volume: 1379 start-page: 233 year: 1998 ident: 3413_CR45 publication-title: Biochim Biophys Acta doi: 10.1016/S0304-4165(97)00104-9 – volume: 26 start-page: 379 year: 1977 ident: 3413_CR11 publication-title: Atherosclerosis doi: 10.1016/0021-9150(77)90092-2 – volume: 25 start-page: 446 year: 1979 ident: 3413_CR24 publication-title: Clin Chem doi: 10.1093/clinchem/25.3.446 – volume: 65 start-page: 868 year: 2014 ident: 3413_CR16 publication-title: Int J Food Sci Nutr doi: 10.3109/09637486.2014.925428 – volume: 19 start-page: 170 year: 2014 ident: 3413_CR41 publication-title: Redox Rep doi: 10.1179/1351000214Y.0000000088 – volume: 49 start-page: 330 year: 2007 ident: 3413_CR56 publication-title: Prog Cardiovasc Dis doi: 10.1016/j.pcad.2006.10.002 – volume: 133 start-page: 1668 year: 2016 ident: 3413_CR6 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.115.017443 – volume: 373 start-page: 555 year: 2008 ident: 3413_CR51 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2008.06.067 – volume: 286 start-page: 11 year: 2006 ident: 3413_CR8 publication-title: Mol Cell Biochem doi: 10.1007/s11010-005-9003-8 – volume: 70 start-page: 158 year: 1967 ident: 3413_CR28 publication-title: J Lab Clin Med – volume: 51 start-page: 806 year: 2013 ident: 3413_CR20 publication-title: Pharm Biol doi: 10.3109/13880209.2013.766895 – volume: 86 start-page: 271 year: 1978 ident: 3413_CR30 publication-title: Anal Biochem doi: 10.1016/0003-2697(78)90342-1 – volume: 44 start-page: 193 year: 1973 ident: 3413_CR23 publication-title: Clin Chim Acta doi: 10.1016/0009-8981(73)90381-1 – volume: 126 start-page: 131 year: 1982 ident: 3413_CR31 publication-title: Anal Biochem doi: 10.1016/0003-2697(82)90118-X – volume: 111 start-page: 146 year: 2015 ident: 3413_CR19 publication-title: Ecotoxicol Environ Saf doi: 10.1016/j.ecoenv.2014.10.019 – volume: 32 start-page: 1563 year: 2007 ident: 3413_CR40 publication-title: Zhongguo Zhong Yao Za Zhi – volume: 113 start-page: 754 year: 2013 ident: 3413_CR7 publication-title: Circ Res doi: 10.1161/CIRCRESAHA.113.300218 – volume: 14 start-page: 56 year: 2013 ident: 3413_CR47 publication-title: Cancer Biol Ther doi: 10.4161/cbt.22628 – volume: 218 start-page: 164 year: 2006 ident: 3413_CR42 publication-title: Toxicology doi: 10.1016/j.tox.2005.10.015 – volume: 42 start-page: 1766 year: 2008 ident: 3413_CR12 publication-title: Ann Pharmacother doi: 10.1345/aph.1L319 – volume: 302 start-page: H1603 year: 2012 ident: 3413_CR52 publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00844.2011 – volume: 13 start-page: 917 year: 2010 ident: 3413_CR53 publication-title: J Med Food doi: 10.1089/jmf.2009.0162 – volume: 29 start-page: 3451 year: 2008 ident: 3413_CR1 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2008.04.048 – volume: 90 start-page: 935 year: 2017 ident: 3413_CR10 publication-title: Biomed Pharmacother doi: 10.1016/j.biopha.2017.04.033 – volume: 434 start-page: 33 year: 2005 ident: 3413_CR58 publication-title: Arch Biochem Biophys doi: 10.1016/j.abb.2004.08.001 – volume: 289 start-page: H722 year: 2005 ident: 3413_CR35 publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.01249.2004 – volume: 18 start-page: 872 year: 2002 ident: 3413_CR36 publication-title: Nutrition doi: 10.1016/S0899-9007(02)00916-4 – volume: 4 start-page: 4113 year: 2006 ident: 3413_CR49 publication-title: Org Biomol Chem doi: 10.1039/b611506c – volume: 117 start-page: 123 year: 2008 ident: 3413_CR55 publication-title: J Ethnopharmacol doi: 10.1016/j.jep.2008.01.022 – volume: 61 start-page: 882 year: 1963 ident: 3413_CR29 publication-title: J Lab Clin Med – volume: 27 start-page: 922 year: 1999 ident: 3413_CR37 publication-title: Free Radic Biol Med doi: 10.1016/S0891-5849(99)00176-8 – volume: 415 start-page: 1 year: 2001 ident: 3413_CR33 publication-title: Eur J Pharmacol doi: 10.1016/S0014-2999(01)00765-8 – volume: 4 start-page: 1229 year: 2013 ident: 3413_CR17 publication-title: Food Funct doi: 10.1039/c3fo60057b – volume: 52 start-page: 1009 year: 2014 ident: 3413_CR15 publication-title: Pharm Biol doi: 10.3109/13880209.2013.876053 – volume: 46 start-page: 849 year: 1972 ident: 3413_CR27 publication-title: Biochem Biophys Res Commun doi: 10.1016/S0006-291X(72)80218-3 – volume: 23 start-page: 15 year: 2007 ident: 3413_CR2 publication-title: Cell Biol Toxicol doi: 10.1007/s10565-006-0140-y – volume: 148 start-page: 183 year: 1995 ident: 3413_CR46 publication-title: Mol Cell Biochem doi: 10.1007/BF00928155 – volume: 105 start-page: 121 year: 1984 ident: 3413_CR26 publication-title: Methods Enzymol doi: 10.1016/S0076-6879(84)05016-3 – volume: 29 start-page: 679 year: 2015 ident: 3413_CR18 publication-title: Int Immunopharmacol doi: 10.1016/j.intimp.2015.09.010 – volume: 15 start-page: 170 year: 2013 ident: 3413_CR13 publication-title: Isr Med Assoc J – volume: 187 start-page: 40 year: 2009 ident: 3413_CR39 publication-title: Toxicol Lett doi: 10.1016/j.toxlet.2009.01.025 – volume: 21 start-page: 1238 year: 2010 ident: 3413_CR50 publication-title: J Nutr Biochem doi: 10.1016/j.jnutbio.2009.11.001 – volume: 13 start-page: 1847 year: 2005 ident: 3413_CR32 publication-title: Bioorg Med Chem doi: 10.1016/j.bmc.2004.10.066 – volume: 45 start-page: 1024 issue: 11 year: 2015 ident: 3413_CR3 publication-title: Xenobiotica doi: 10.3109/00498254.2015.1034223
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Snippet	Purpose Doxorubicin (DOX) is a highly active antineoplastic agent; however, its clinical use is limited due to associated cardiotoxicity. This study was... Doxorubicin (DOX) is a highly active antineoplastic agent; however, its clinical use is limited due to associated cardiotoxicity. This study was performed to...
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SubjectTerms	Animals Antibiotics, Antineoplastic - toxicity Antioxidants Antioxidants - administration & dosage Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Biomarkers - blood Cancer Research Cardiotoxicity Cardiotoxicity - etiology Cardiotoxicity - prevention & control Caspase Caspase-3 Catalase Creatine Creatine kinase Cyclooxygenase-2 Cytokines Cytokines - metabolism Dose-Response Relationship, Drug Doxorubicin Doxorubicin - toxicity Glutathione peroxidase Heart Heart diseases Inflammation Inflammation - chemically induced Inflammation - prevention & control Intoxication L-Lactate dehydrogenase Lactic acid Male Malondialdehyde Malondialdehyde - metabolism Medicine Medicine & Public Health Mice Nitric oxide Nitric Oxide - metabolism Oncology Original Article Oxidative stress Oxidative Stress - drug effects Pharmacology/Toxicology Rodents Serum levels Sulfinic Acids - administration & dosage Sulfinic Acids - pharmacology Superoxide dismutase
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Title	Allicin ameliorates doxorubicin-induced cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis
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