A potential food biopreservative, CecXJ-37N, non-covalently intercalates into the nucleotides of bacterial genomic DNA beyond membrane attack

•CecXJ-37N shows small MICs (0.25–7.8μM) against 8 food-borne pathogenic strains.•CecXJ-37N shows low hemolysis and no cytotoxicity to normal mammalian cells.•CecXJ-37N induces pore-forming on E. coli cell membrane and causes cytolysis.•CecXJ-37N penetrates bacterial cell membrane and interacts with...

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Bibliographic Details
Published in:	Food chemistry Vol. 217; pp. 576 - 584
Main Authors:	Liu, Dongliang, Liu, Jun, Li, Jinyao, Xia, Lijie, Yang, Jianhua, Sun, Surong, Ma, Ji, Zhang, Fuchun
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 15.02.2017
Subjects:	Amide modification Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology antibacterial properties Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - pharmacology Antimicrobial peptide Cell Membrane - drug effects Cell membrane penetration Cell Survival - drug effects cytoplasm cytotoxicity DNA DNA intercalation DNA, Bacterial - chemistry Escherichia coli Escherichia coli - drug effects flow cytometry fluorescence microscopy food biopreservatives Food Contamination - prevention & control food industry Food Microbiology Food preservative Food Preservatives - chemistry Food Preservatives - pharmacology Food-borne pathogen genome Genome, Bacterial hydrolysis mechanism of action Mice Microbial Sensitivity Tests Molecular Structure NIH 3T3 Cells novel foods nucleotides pepsin scanning electron microscopy trypsin ultraviolet-visible spectroscopy Food preservative Cell membrane penetration Food-borne pathogen Amide modification DNA intercalation Antimicrobial peptide
ISSN:	0308-8146, 1873-7072, 1873-7072
Online Access:	Get full text
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