Presence of the posterior pituitary bright spot sign on MRI in the general population: a comparison between 1.5 and 3T MRI and between 2D-T1 spin-echo- and 3D-T1 gradient-echo sequences

Purpose To describe the prevalence of the posterior pituitary bright spot (PPBS) in the general population on 1.5 and 3T MRI examinations and on 2D-T1 spin-echo (SE) and 3D-T1 gradient-echo (GE) sequences. Materials and methods 1017 subjects who received an MRI of the brain for aspecific neurologica...

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Vydáno v:Pituitary Ročník 21; číslo 4; s. 379 - 383
Hlavní autoři: Klyn, Verena, Dekeyzer, Sven, Van Eetvelde, Ruth, Roels, Pieter, Vergauwen, Ortwin, Devolder, Pieter, Wiesmann, Martin, Achten, Eric, Nikoubashman, Omid
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York Springer US 01.08.2018
Springer Nature B.V
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ISSN:1386-341X, 1573-7403, 1573-7403
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Abstract Purpose To describe the prevalence of the posterior pituitary bright spot (PPBS) in the general population on 1.5 and 3T MRI examinations and on 2D-T1 spin-echo (SE) and 3D-T1 gradient-echo (GE) sequences. Materials and methods 1017 subjects who received an MRI of the brain for aspecific neurological complaints were included. MRI was performed on 1.5T in 64.5% and on 3T in 35.5% of subjects. Presence of the PPBS was evaluated on sagittal 2D T1-SE echo images with slice thickness 3 mm in 67.5% and on sagittal 3D T1-GE with slice thickness 0.9 mm in 32.5% of subjects. Results The PPBS was detectable in 95.9% of subjects. After correction for sex and age, no statistically significant difference could be seen concerning PPBS detection between 1.5 and 3T MRI examinations (p = 0.533), nor between 2D T1-SE and 3D T1-GE sequences (p = 0.217). There was a statistically significant association between increasing age and the absence of the PPBS (p < 0.001). The PPBS could not be identified in 6.2% of male subjects, compared to 2.2% of female subjects (p = 0.01). Discussion Absence of the PPBS can be seen in 4.1% of patients undergoing MRI of the brain for non-endocrinological reasons. Neither field-strength nor the use of a thick-sliced 2D T1-SE versus a thin-sliced 3D T1-GE sequence influenced the detectability of the PPBS. There is a statistically significant association between increasing age and male sex and the absence of the PPBS.
AbstractList Purpose To describe the prevalence of the posterior pituitary bright spot (PPBS) in the general population on 1.5 and 3T MRI examinations and on 2D-T1 spin-echo (SE) and 3D-T1 gradient-echo (GE) sequences. Materials and methods 1017 subjects who received an MRI of the brain for aspecific neurological complaints were included. MRI was performed on 1.5T in 64.5% and on 3T in 35.5% of subjects. Presence of the PPBS was evaluated on sagittal 2D T1-SE echo images with slice thickness 3 mm in 67.5% and on sagittal 3D T1-GE with slice thickness 0.9 mm in 32.5% of subjects. Results The PPBS was detectable in 95.9% of subjects. After correction for sex and age, no statistically significant difference could be seen concerning PPBS detection between 1.5 and 3T MRI examinations (p = 0.533), nor between 2D T1-SE and 3D T1-GE sequences (p = 0.217). There was a statistically significant association between increasing age and the absence of the PPBS (p < 0.001). The PPBS could not be identified in 6.2% of male subjects, compared to 2.2% of female subjects (p = 0.01). Discussion Absence of the PPBS can be seen in 4.1% of patients undergoing MRI of the brain for non-endocrinological reasons. Neither field-strength nor the use of a thick-sliced 2D T1-SE versus a thin-sliced 3D T1-GE sequence influenced the detectability of the PPBS. There is a statistically significant association between increasing age and male sex and the absence of the PPBS.
To describe the prevalence of the posterior pituitary bright spot (PPBS) in the general population on 1.5 and 3T MRI examinations and on 2D-T1 spin-echo (SE) and 3D-T1 gradient-echo (GE) sequences.PURPOSETo describe the prevalence of the posterior pituitary bright spot (PPBS) in the general population on 1.5 and 3T MRI examinations and on 2D-T1 spin-echo (SE) and 3D-T1 gradient-echo (GE) sequences.1017 subjects who received an MRI of the brain for aspecific neurological complaints were included. MRI was performed on 1.5T in 64.5% and on 3T in 35.5% of subjects. Presence of the PPBS was evaluated on sagittal 2D T1-SE echo images with slice thickness 3 mm in 67.5% and on sagittal 3D T1-GE with slice thickness 0.9 mm in 32.5% of subjects.MATERIALS AND METHODS1017 subjects who received an MRI of the brain for aspecific neurological complaints were included. MRI was performed on 1.5T in 64.5% and on 3T in 35.5% of subjects. Presence of the PPBS was evaluated on sagittal 2D T1-SE echo images with slice thickness 3 mm in 67.5% and on sagittal 3D T1-GE with slice thickness 0.9 mm in 32.5% of subjects.The PPBS was detectable in 95.9% of subjects. After correction for sex and age, no statistically significant difference could be seen concerning PPBS detection between 1.5 and 3T MRI examinations (p = 0.533), nor between 2D T1-SE and 3D T1-GE sequences (p = 0.217). There was a statistically significant association between increasing age and the absence of the PPBS (p < 0.001). The PPBS could not be identified in 6.2% of male subjects, compared to 2.2% of female subjects (p = 0.01).RESULTSThe PPBS was detectable in 95.9% of subjects. After correction for sex and age, no statistically significant difference could be seen concerning PPBS detection between 1.5 and 3T MRI examinations (p = 0.533), nor between 2D T1-SE and 3D T1-GE sequences (p = 0.217). There was a statistically significant association between increasing age and the absence of the PPBS (p < 0.001). The PPBS could not be identified in 6.2% of male subjects, compared to 2.2% of female subjects (p = 0.01).Absence of the PPBS can be seen in 4.1% of patients undergoing MRI of the brain for non-endocrinological reasons. Neither field-strength nor the use of a thick-sliced 2D T1-SE versus a thin-sliced 3D T1-GE sequence influenced the detectability of the PPBS. There is a statistically significant association between increasing age and male sex and the absence of the PPBS.DISCUSSIONAbsence of the PPBS can be seen in 4.1% of patients undergoing MRI of the brain for non-endocrinological reasons. Neither field-strength nor the use of a thick-sliced 2D T1-SE versus a thin-sliced 3D T1-GE sequence influenced the detectability of the PPBS. There is a statistically significant association between increasing age and male sex and the absence of the PPBS.
To describe the prevalence of the posterior pituitary bright spot (PPBS) in the general population on 1.5 and 3T MRI examinations and on 2D-T1 spin-echo (SE) and 3D-T1 gradient-echo (GE) sequences. 1017 subjects who received an MRI of the brain for aspecific neurological complaints were included. MRI was performed on 1.5T in 64.5% and on 3T in 35.5% of subjects. Presence of the PPBS was evaluated on sagittal 2D T1-SE echo images with slice thickness 3 mm in 67.5% and on sagittal 3D T1-GE with slice thickness 0.9 mm in 32.5% of subjects. The PPBS was detectable in 95.9% of subjects. After correction for sex and age, no statistically significant difference could be seen concerning PPBS detection between 1.5 and 3T MRI examinations (p = 0.533), nor between 2D T1-SE and 3D T1-GE sequences (p = 0.217). There was a statistically significant association between increasing age and the absence of the PPBS (p < 0.001). The PPBS could not be identified in 6.2% of male subjects, compared to 2.2% of female subjects (p = 0.01). Absence of the PPBS can be seen in 4.1% of patients undergoing MRI of the brain for non-endocrinological reasons. Neither field-strength nor the use of a thick-sliced 2D T1-SE versus a thin-sliced 3D T1-GE sequence influenced the detectability of the PPBS. There is a statistically significant association between increasing age and male sex and the absence of the PPBS.
PurposeTo describe the prevalence of the posterior pituitary bright spot (PPBS) in the general population on 1.5 and 3T MRI examinations and on 2D-T1 spin-echo (SE) and 3D-T1 gradient-echo (GE) sequences.Materials and methods1017 subjects who received an MRI of the brain for aspecific neurological complaints were included. MRI was performed on 1.5T in 64.5% and on 3T in 35.5% of subjects. Presence of the PPBS was evaluated on sagittal 2D T1-SE echo images with slice thickness 3 mm in 67.5% and on sagittal 3D T1-GE with slice thickness 0.9 mm in 32.5% of subjects.ResultsThe PPBS was detectable in 95.9% of subjects. After correction for sex and age, no statistically significant difference could be seen concerning PPBS detection between 1.5 and 3T MRI examinations (p = 0.533), nor between 2D T1-SE and 3D T1-GE sequences (p = 0.217). There was a statistically significant association between increasing age and the absence of the PPBS (p < 0.001). The PPBS could not be identified in 6.2% of male subjects, compared to 2.2% of female subjects (p = 0.01).DiscussionAbsence of the PPBS can be seen in 4.1% of patients undergoing MRI of the brain for non-endocrinological reasons. Neither field-strength nor the use of a thick-sliced 2D T1-SE versus a thin-sliced 3D T1-GE sequence influenced the detectability of the PPBS. There is a statistically significant association between increasing age and male sex and the absence of the PPBS.
Author Roels, Pieter
Devolder, Pieter
Achten, Eric
Wiesmann, Martin
Klyn, Verena
Dekeyzer, Sven
Van Eetvelde, Ruth
Vergauwen, Ortwin
Nikoubashman, Omid
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  organization: Department of Diagnostic and Interventional Neuroradiology, RWTH University Hospital Aachen
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  orcidid: 0000-0002-7779-5740
  surname: Dekeyzer
  fullname: Dekeyzer, Sven
  email: sven.dekeyzer@gmail.com
  organization: Department of Diagnostic and Interventional Neuroradiology, RWTH University Hospital Aachen, Department of Medical Imaging, Onze-Lieve-Vrouw Ziekenhuis Aalst
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  givenname: Ruth
  surname: Van Eetvelde
  fullname: Van Eetvelde, Ruth
  organization: Department of Medical Imaging, Onze-Lieve-Vrouw Ziekenhuis Aalst
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  surname: Roels
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  organization: Department of Medical Imaging, University Hospital (UZ) Ghent
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Keywords Pituitary bright spot
Posterior pituitary
MRI
Vasopressin
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PublicationSubtitle The Official Journal of the Pituitary Society
PublicationTitle Pituitary
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PeruccaJBoubyNValeixPBankirLSex difference in urine concentration across differing ages, sodium intake, and level of kidney diseaseAm J Physiol Regul Integr Comp Physiol20071699048710.1152/ajpregu.00500.2006
FujisawaIPosterior lobe of the pituitary in diabetes insipidus: MR findingsJ Comput Assist Tomogr19871122122510.1097/00004728-198703000-0000438191181:STN:280:DyaL2s7jvVKnsA%3D%3D
TeranoTSeyaATamuraYYoshidaSHirayamaTCharacteristics of the pituitary gland in elderly subjects from magnetic resonance images: relationship to pituitary hormone secretionClin Endocrinol (Oxford)19964527327910.1046/j.1365-2265.1996.00555.x1:STN:280:DyaK2s7gs1yitA%3D%3D
CroftonJTDustanHShareLBrooksDPVasopressin secretion in normotensive black and white men and women on normal and low sodium dietsJ Endocrinol198610819119910.1677/joe.0.108019139505261:CAS:528:DyaL28Xmt1Ggsg%3D%3D
MarkLPHigh-intensity signals within the posterior pituitary fossa: a study with fat-suppression MR techniquesAJNR AM J Neuroradiol19911252953220585091:STN:280:DyaK3M3otFKhtA%3D%3D
OsbornAGOsborn’s brain, imaging, pathology, and anatomy2013Salt Lake CityAmirsys Pub.683687
ColomboNPosterior pituitary gland: appearance on MR images in normal and pathologic statesRadiology1987165248148510.1148/radiology.165.2.365937036593701:STN:280:DyaL1c%2FhslSjtQ%3D%3D
Diabetes Data and Statistics (2017) Centers for Disease Control and Prevention Website. https://www.cdc.gov/diabetes/data/index.html. Accessed 05 June 2017
YamamotoAInfluence of age and sex on signal intensities of the posterior lobe of the pituitary gland on T1-weighted images from 3 T MRIJpn J Radiol201331318619210.1007/s11604-012-0168-223268123
BonnevilleFCattinFMarsot-DupuchKDormontDBonnevilleJFChirasJT1 signal hyperintensity in the sellar region: spectrum of findingsRadiographics2006269311310.1148/rg.26105504516418246
LP Mark (885_CR2) 1991; 12
BS Brooks (885_CR8) 1989; 10
I Fujisawa (885_CR4) 1987; 11
JT Crofton (885_CR13) 1986; 108
W Liu (885_CR6) 2016
AG Osborn (885_CR1) 2013
F Bonneville (885_CR3) 2006; 26
885_CR11
I Fujisawa (885_CR5) 2004; 16
N Colombo (885_CR7) 1987; 165
A Yamamoto (885_CR9) 2013; 31
J Perucca (885_CR12) 2007
T Terano (885_CR10) 1996; 45
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8949564 - Clin Endocrinol (Oxf). 1996 Sep;45(3):273-9
16990487 - Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R700-5
23268123 - Jpn J Radiol. 2013 Mar;31(3):186-91
27118970 - Int J Endocrinol. 2016;2016:6365830
15089965 - J Neuroendocrinol. 2004 Apr;16(4):297-302
3819118 - J Comput Assist Tomogr. 1987 Mar-Apr;11(2):221-5
3950526 - J Endocrinol. 1986 Feb;108(2):191-9
16418246 - Radiographics. 2006 Jan-Feb;26(1):93-113
2505538 - AJNR Am J Neuroradiol. 1989 Sep-Oct;10(5):943-8
2058509 - AJNR Am J Neuroradiol. 1991 May-Jun;12(3):529-32
References_xml – reference: PeruccaJBoubyNValeixPBankirLSex difference in urine concentration across differing ages, sodium intake, and level of kidney diseaseAm J Physiol Regul Integr Comp Physiol20071699048710.1152/ajpregu.00500.2006
– reference: FujisawaIPosterior lobe of the pituitary in diabetes insipidus: MR findingsJ Comput Assist Tomogr19871122122510.1097/00004728-198703000-0000438191181:STN:280:DyaL2s7jvVKnsA%3D%3D
– reference: ColomboNPosterior pituitary gland: appearance on MR images in normal and pathologic statesRadiology1987165248148510.1148/radiology.165.2.365937036593701:STN:280:DyaL1c%2FhslSjtQ%3D%3D
– reference: MarkLPHigh-intensity signals within the posterior pituitary fossa: a study with fat-suppression MR techniquesAJNR AM J Neuroradiol19911252953220585091:STN:280:DyaK3M3otFKhtA%3D%3D
– reference: BonnevilleFCattinFMarsot-DupuchKDormontDBonnevilleJFChirasJT1 signal hyperintensity in the sellar region: spectrum of findingsRadiographics2006269311310.1148/rg.26105504516418246
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– reference: YamamotoAInfluence of age and sex on signal intensities of the posterior lobe of the pituitary gland on T1-weighted images from 3 T MRIJpn J Radiol201331318619210.1007/s11604-012-0168-223268123
– reference: TeranoTSeyaATamuraYYoshidaSHirayamaTCharacteristics of the pituitary gland in elderly subjects from magnetic resonance images: relationship to pituitary hormone secretionClin Endocrinol (Oxford)19964527327910.1046/j.1365-2265.1996.00555.x1:STN:280:DyaK2s7gs1yitA%3D%3D
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– reference: OsbornAGOsborn’s brain, imaging, pathology, and anatomy2013Salt Lake CityAmirsys Pub.683687
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– volume: 26
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  volume-title: Osborn’s brain, imaging, pathology, and anatomy
  year: 2013
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– volume: 31
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– volume: 45
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  year: 1996
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  doi: 10.1046/j.1365-2265.1996.00555.x
– volume: 11
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– volume: 108
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  doi: 10.1677/joe.0.1080191
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– reference: 15089965 - J Neuroendocrinol. 2004 Apr;16(4):297-302
– reference: 3950526 - J Endocrinol. 1986 Feb;108(2):191-9
– reference: 16418246 - Radiographics. 2006 Jan-Feb;26(1):93-113
– reference: 3659370 - Radiology. 1987 Nov;165(2):481-5
– reference: 27118970 - Int J Endocrinol. 2016;2016:6365830
– reference: 2058509 - AJNR Am J Neuroradiol. 1991 May-Jun;12(3):529-32
– reference: 8949564 - Clin Endocrinol (Oxf). 1996 Sep;45(3):273-9
– reference: 16990487 - Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R700-5
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Snippet Purpose To describe the prevalence of the posterior pituitary bright spot (PPBS) in the general population on 1.5 and 3T MRI examinations and on 2D-T1...
To describe the prevalence of the posterior pituitary bright spot (PPBS) in the general population on 1.5 and 3T MRI examinations and on 2D-T1 spin-echo (SE)...
PurposeTo describe the prevalence of the posterior pituitary bright spot (PPBS) in the general population on 1.5 and 3T MRI examinations and on 2D-T1 spin-echo...
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StartPage 379
SubjectTerms Age
Endocrinology
Human Physiology
Magnetic resonance imaging
Medicine
Medicine & Public Health
Pituitary (posterior)
Statistical analysis
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Title Presence of the posterior pituitary bright spot sign on MRI in the general population: a comparison between 1.5 and 3T MRI and between 2D-T1 spin-echo- and 3D-T1 gradient-echo sequences
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