Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis

Cellular plasticity and de-differentiation are hallmarks of tissue/organ regenerative capacity in diverse species. Despite a more restricted capacity for regeneration, humans with age-related chronic diseases, such as cancer and fibrosis, show evidence of a recapitulation of developmental gene progr...

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Bibliographic Details
Published in:	Scientific reports Vol. 6; no. 1; p. 37445
Main Authors:	Chanda, Diptiman, Kurundkar, Ashish, Rangarajan, Sunad, Locy, Morgan, Bernard, Karen, Sharma, Nirmal S., Logsdon, Naomi J., Liu, Hui, Crossman, David K., Horowitz, Jeffrey C., De Langhe, Stijn, Thannickal, Victor J.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 21.11.2016 Nature Publishing Group
Subjects:	13/106 14/63 38/77 631/532/7 631/553/2711 692/699/1785/3193 82/1 82/29 82/51 Age Alveoli Bronchoalveolar Lavage Fluid - cytology Bronchus Cancer Cellular Reprogramming Disease Disease Progression Down-Regulation - genetics Fibroblast growth factor 10 Fibroblast Growth Factor 10 - metabolism Fibrosis Gene expression Gene Expression Profiling Gene Regulatory Networks Genes, Developmental Hedgehog Proteins - metabolism Humanities and Social Sciences Humans Idiopathic Pulmonary Fibrosis - genetics Idiopathic Pulmonary Fibrosis - pathology Immunohistochemistry Lung - pathology Lung diseases Mesenchymal stem cells Mesenchymal Stem Cells - metabolism Mesenchymal Stem Cells - pathology Mesenchyme Morphogenesis multidisciplinary Pattern formation Pulmonary fibrosis Reproducibility of Results Science Signal Transduction - genetics Species diversity Stromal cells Transforming Growth Factor beta - metabolism Transforming growth factor-b1 Up-Regulation - genetics
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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