Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness

While most cancer nanomedicine is designed to eliminate cancer, the nanomaterial per se can lead to the formation of micrometre-sized gaps in the blood vessel endothelial walls. Nanomaterials-induced endothelial leakiness (NanoEL) might favour intravasation of surviving cancer cells into the surroun...

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Bibliographic Details
Published in:	Nature nanotechnology Vol. 14; no. 3; pp. 279 - 286
Main Authors:	Peng, Fei, Setyawati, Magdiel Inggrid, Tee, Jie Kai, Ding, Xianguang, Wang, Jinping, Nga, Min En, Ho, Han Kiat, Leong, David Tai
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.03.2019
Subjects:	Animal models Animals Blood vessels Blood Vessels - pathology Breast cancer Breast Neoplasms - pathology Cadherins Cancer Cell Line, Tumor Disruption Endothelial Cells - pathology Extravasation Extravasation of Diagnostic and Therapeutic Materials - pathology Female Gold Humans Metal Nanoparticles - chemistry Metastases Metastasis Mice Nanomaterials Nanoparticles Nanotechnology Neoplasm Metastasis Neoplastic Cells, Circulating - pathology Permeability Silica Silicon dioxide Titanium - chemistry Titanium dioxide
ISSN:	1748-3387, 1748-3395, 1748-3395
Online Access:	Get full text
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