Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1

Hypoxia-induced replication stress is one of the most physiologically relevant signals known to activate ATM in tumors. Recently, the ATM interactor (ATMIN) was identified as critical for replication stress-induced activation of ATM in response to aphidicolin and hydroxyurea. This suggests an essent...

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Bibliographic Details
Published in:	Scientific reports Vol. 6; no. 1; p. 21698
Main Authors:	Leszczynska, Katarzyna B., Göttgens, Eva-Leonne, Biasoli, Deborah, Olcina, Monica M., Ient, Jonathan, Anbalagan, Selvakumar, Bernhardt, Stephan, Giaccia, Amato J., Hammond, Ester M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 15.02.2016 Nature Publishing Group
Subjects:	13/106 13/89 13/95 631/67/327 631/80/86 82/1 82/29 Cell Hypoxia Cell Line Cytoplasmic Dyneins - biosynthesis Gene Expression Regulation Humanities and Social Sciences Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism multidisciplinary p53 Protein Science Transcription Factors - metabolism Tumor Suppressor Protein p53 - metabolism Tumors
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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