Optic neuritis following COVID-19 vaccination: Do autoimmune diseases play a role?

We report two cases of optic neuritis following Pfizer-BioNTech COVID-19 vaccination in patients with autoimmune diseases. Post-vaccine optic neuritis, although rare, is reported in the literature and an autoimmune mechanism seems to be involved, especially in genetically predisposed subjects. Repor...

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Bibliographic Details
Published in:European journal of ophthalmology Vol. 33; no. 4; p. NP46
Main Authors: Pirani, Vittorio, Pelliccioni, Paolo, Carpenè, Maria Jolanda, Nicolai, Michele, Barbotti, Federica, Franceschi, Alessandro, Mariotti, Cesare
Format: Journal Article
Language:English
Published: United States 01.07.2023
Subjects:
Autoimmune Diseases - complications
COVID-19 - prevention & control
COVID-19 Vaccines - adverse effects
Humans
Male
Optic Neuritis - etiology
Vaccination - adverse effects
optic neuropathy
Neuro ophthalmology
immunology
neuro imaging
optic neuritis
ISSN:1724-6016, 1724-6016
Online Access:Get more information
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Summary:We report two cases of optic neuritis following Pfizer-BioNTech COVID-19 vaccination in patients with autoimmune diseases. Post-vaccine optic neuritis, although rare, is reported in the literature and an autoimmune mechanism seems to be involved, especially in genetically predisposed subjects. Report of two cases of optic neuritis following COVID-19 vaccination in patients with autoimmune diseases. He novelty of this article is the fact that the two patients had a medical history of autoimmune diseases (Hashimoto thyroiditis and ankylosing spondylitis), a point of interest for research because it is not yet clear whether this could constitute a risk factor for adverse events after vaccination. The reactogenicity of COVID-19 mRNA vaccine in individuals suffering from immune-mediated diseases is yet to be elucidated and it is being increasingly investigated. Our paper supports the hypothesis that patients who are already affected or predisposed to autoimmune or autoinflammatory disorders should be carefully evaluated for the benefits and risks of COVID-19 mRNA vaccination.
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ISSN:1724-6016
1724-6016
DOI:10.1177/11206721221118736