The uptake of presymptomatic genetic testing in hereditary breast-ovarian cancer and Lynch syndrome: a systematic review of the literature and implications for clinical practice

Following the identification in a proband of a germline BRCA1 / BRCA2 mutation in hereditary breast-ovarian cancer (HBOC) or a DNA mismatch repair gene mutation in Lynch syndrome (LS) he or she will be asked to inform at-risk family members about the option for presymptomatic DNA testing. However, i...

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Bibliographic Details
Published in:	Familial cancer Vol. 18; no. 1; pp. 127 - 135
Main Authors:	Menko, Fred H, ter Stege, Jacqueline A, van der Kolk, Lizet E, Jeanson, Kiki N, Schats, Winnie, Moha, Daoud Ait, Bleiker, Eveline M A
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01.01.2019 Springer Nature B.V
Subjects:	Biomedical and Life Sciences Biomedicine BRCA1 protein BRCA1 Protein - genetics BRCA2 protein BRCA2 Protein - genetics Breast Breast cancer Cancer Research Clinical medicine Colorectal cancer Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Colorectal Neoplasms, Hereditary Nonpolyposis - prevention & control DNA repair Early Detection of Cancer - methods Early Detection of Cancer - statistics & numerical data Epidemiology Family Female Genetic disorders Genetic Predisposition to Disease Genetic screening Genetic Testing - statistics & numerical data Health Services Needs and Demand - statistics & numerical data Hereditary Breast and Ovarian Cancer Syndrome - diagnosis Hereditary Breast and Ovarian Cancer Syndrome - genetics Hereditary Breast and Ovarian Cancer Syndrome - prevention & control Human Genetics Humans Information processing Literature reviews Mismatch repair Mutation Ovarian cancer Patient Acceptance of Health Care - statistics & numerical data Pedigree Point mutation Review Hereditary breast-ovarian cancer Informing family members Duty to warn Direct contact Presymptomatic genetic testing Cascade screening Lynch syndrome
ISSN:	1389-9600, 1573-7292, 1573-7292
Online Access:	Get full text
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