A new transgenic mouse model for conditional overexpression of the Polycomb Group protein EZH2

The Polycomb Group protein EZH2 is upregulated in most prostate cancers, and its overexpression is associated with poor prognosis. Most insights into the functional role of EZH2 in prostate cancer have been gained using cell lines and EZH2 inactivation studies. However, the question remains whether...

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Veröffentlicht in:	Transgenic research Jg. 26; H. 2; S. 187 - 196
Hauptverfasser:	Koppens, Martijn A. J., Tanger, Ellen, Nacerddine, Karim, Westerman, Bart, Song, Ji-Ying, van Lohuizen, Maarten
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Cham Springer International Publishing 01.04.2017 Springer Nature B.V
Schlagworte:	Animal Genetics and Genomics animal models Animals bioluminescence Biomedical and Life Sciences Biomedical Engineering/Biotechnology carcinogenesis crossing Disease Models, Animal Enhancer of Zeste Homolog 2 Protein - biosynthesis Enhancer of Zeste Homolog 2 Protein - genetics Gene Expression Regulation - genetics Gene Expression Regulation, Neoplastic gene overexpression Genetic Engineering Humans image analysis Life Sciences luciferase Male metastasis Mice Mice, Transgenic Molecular Medicine monitoring open reading frames Original Paper Plant Genetics and Genomics Polycomb Repressive Complex 1 - genetics prognosis prostatic neoplasms Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Proto-Oncogene Proteins - genetics PTEN Phosphohydrolase - genetics tissues transcription (genetics) transgenes transgenic animals Transgenics Polycomb Mouse model Prostate cancer EZH2
ISSN:	0962-8819, 1573-9368
Online-Zugang:	Volltext
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