High-resolution subject-specific mitral valve imaging and modeling: experimental and computational methods

The diversity of mitral valve (MV) geometries and multitude of surgical options for correction of MV diseases necessitates the use of computational modeling. Numerical simulations of the MV would allow surgeons and engineers to evaluate repairs, devices, procedures, and concepts before performing th...

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Vydáno v:	Biomechanics and modeling in mechanobiology Ročník 15; číslo 6; s. 1619 - 1630
Hlavní autoři:	Toma, Milan, Bloodworth, Charles H., Einstein, Daniel R., Pierce, Eric L., Cochran, Richard P., Yoganathan, Ajit P., Kunzelman, Karyn S.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2016 Springer Nature B.V
Témata:	Animals Biological and Medical Physics Biomedical Engineering and Bioengineering Biophysics Closures Computation Computed tomography Computer Simulation Diastole Diseases Engineering Imaging Imaging, Three-Dimensional Mathematical models Mitral Valve - anatomy & histology Mitral Valve - physiology Models, Cardiovascular Sheep Simulation Stress, Mechanical Surgery Theoretical and Applied Mechanics Valves X-Ray Microtomography Fluid–structure interaction Mitral valve Fixation Glutaraldehyde Comprehensive computational model Chordae tendineae Chordal structure Smooth particle hydrodynamics
ISSN:	1617-7959, 1617-7940, 1617-7940
On-line přístup:	Získat plný text
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Popis
Shrnutí:	The diversity of mitral valve (MV) geometries and multitude of surgical options for correction of MV diseases necessitates the use of computational modeling. Numerical simulations of the MV would allow surgeons and engineers to evaluate repairs, devices, procedures, and concepts before performing them and before moving on to more costly testing modalities. Constructing, tuning, and validating these models rely upon extensive in vitro characterization of valve structure, function, and response to change due to diseases. Micro-computed tomography ( μ CT) allows for unmatched spatial resolution for soft tissue imaging. However, it is still technically challenging to obtain an accurate geometry of the diastolic MV. We discuss here the development of a novel technique for treating MV specimens with glutaraldehyde fixative in order to minimize geometric distortions in preparation for μ CT scanning. The technique provides a resulting MV geometry which is significantly more detailed in chordal structure, accurate in leaflet shape, and closer to its physiological diastolic geometry. In this paper, computational fluid–structure interaction (FSI) simulations are used to show the importance of more detailed subject-specific MV geometry with 3D chordal structure to simulate a proper closure validated against μ CT images of the closed valve. Two computational models, before and after use of the aforementioned technique, are used to simulate closure of the MV.
Bibliografie:	SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23
ISSN:	1617-7959 1617-7940 1617-7940
DOI:	10.1007/s10237-016-0786-1