Computational imaging reveals shape differences between normal and malignant prostates on MRI

We seek to characterize differences in the shape of the prostate and the central gland (combined central and transitional zones) between men with biopsy confirmed prostate cancer and men who were identified as not having prostate cancer either on account of a negative biopsy or had pelvic imaging do...

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Veröffentlicht in:	Scientific reports Jg. 7; H. 1; S. 41261
Hauptverfasser:	Rusu, Mirabela, Purysko, Andrei S., Verma, Sadhna, Kiechle, Jonathan, Gollamudi, Jay, Ghose, Soumya, Herrmann, Karin, Gulani, Vikas, Paspulati, Raj, Ponsky, Lee, Böhm, Maret, Haynes, Anne-Maree, Moses, Daniel, Shnier, Ron, Delprado, Warick, Thompson, James, Stricker, Phillip, Madabhushi, Anant
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.02.2017 Nature Publishing Group
Schlagworte:	692/4025/1752 692/4028/67/589/466 Biopsy Chlorides Colorectal cancer Computer applications Dolphins & porpoises Humanities and Social Sciences Humans Hypertrophy Imaging, Three-Dimensional Institutions Magnetic Resonance Imaging Male Malignancy multidisciplinary Organ Size Pelvis Prostate - pathology Prostate cancer Prostatic Neoplasms - pathology Rectum Science Statistical analysis
ISSN:	2045-2322, 2045-2322
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Abstract	We seek to characterize differences in the shape of the prostate and the central gland (combined central and transitional zones) between men with biopsy confirmed prostate cancer and men who were identified as not having prostate cancer either on account of a negative biopsy or had pelvic imaging done for a non-prostate malignancy. T2w MRI from 70 men were acquired at three institutions. The cancer positive group (PCa+) comprised 35 biopsy positive (Bx+) subjects from three institutions (Gleason scores: 6–9, Stage: T1–T3). The negative group (PCa−) combined 24 biopsy negative (Bx−) from two institutions and 11 subjects diagnosed with rectal cancer but with no clinical or MRI indications of prostate cancer (Cl−). The boundaries of the prostate and central gland were delineated on T2w MRI by two expert raters and were used to construct statistical shape atlases for the PCa+, Bx− and Cl− prostates. An atlas comparison was performed via per-voxel statistical tests to localize shape differences (significance assessed at p < 0.05). The atlas comparison revealed central gland hypertrophy in the Bx− subpopulation, resulting in significant volume and posterior side shape differences relative to PCa+ group. Significant differences in the corresponding prostate shapes were noted at the apex when comparing the Cl− and PCa+ prostates.
AbstractList	We seek to characterize differences in the shape of the prostate and the central gland (combined central and transitional zones) between men with biopsy confirmed prostate cancer and men who were identified as not having prostate cancer either on account of a negative biopsy or had pelvic imaging done for a non-prostate malignancy. T2w MRI from 70 men were acquired at three institutions. The cancer positive group (PCa+) comprised 35 biopsy positive (Bx+) subjects from three institutions (Gleason scores: 6–9, Stage: T1–T3). The negative group (PCa−) combined 24 biopsy negative (Bx−) from two institutions and 11 subjects diagnosed with rectal cancer but with no clinical or MRI indications of prostate cancer (Cl−). The boundaries of the prostate and central gland were delineated on T2w MRI by two expert raters and were used to construct statistical shape atlases for the PCa+, Bx− and Cl− prostates. An atlas comparison was performed via per-voxel statistical tests to localize shape differences (significance assessed at p < 0.05). The atlas comparison revealed central gland hypertrophy in the Bx− subpopulation, resulting in significant volume and posterior side shape differences relative to PCa+ group. Significant differences in the corresponding prostate shapes were noted at the apex when comparing the Cl− and PCa+ prostates. We seek to characterize differences in the shape of the prostate and the central gland (combined central and transitional zones) between men with biopsy confirmed prostate cancer and men who were identified as not having prostate cancer either on account of a negative biopsy or had pelvic imaging done for a non-prostate malignancy. T2w MRI from 70 men were acquired at three institutions. The cancer positive group (PCa+) comprised 35 biopsy positive (Bx+) subjects from three institutions (Gleason scores: 6-9, Stage: T1-T3). The negative group (PCa-) combined 24 biopsy negative (Bx-) from two institutions and 11 subjects diagnosed with rectal cancer but with no clinical or MRI indications of prostate cancer (Cl-). The boundaries of the prostate and central gland were delineated on T2w MRI by two expert raters and were used to construct statistical shape atlases for the PCa+, Bx- and Cl- prostates. An atlas comparison was performed via per-voxel statistical tests to localize shape differences (significance assessed at p < 0.05). The atlas comparison revealed central gland hypertrophy in the Bx- subpopulation, resulting in significant volume and posterior side shape differences relative to PCa+ group. Significant differences in the corresponding prostate shapes were noted at the apex when comparing the Cl- and PCa+ prostates.
ArticleNumber	41261
Author	Moses, Daniel Madabhushi, Anant Ghose, Soumya Ponsky, Lee Gulani, Vikas Delprado, Warick Böhm, Maret Thompson, James Gollamudi, Jay Haynes, Anne-Maree Stricker, Phillip Verma, Sadhna Shnier, Ron Purysko, Andrei S. Paspulati, Raj Kiechle, Jonathan Rusu, Mirabela Herrmann, Karin
Author_xml	– sequence: 1 givenname: Mirabela surname: Rusu fullname: Rusu, Mirabela email: mirabela.rusu@gmail.com organization: Department of Biomedical Engineering, Case Western Reserve University, Present Address: GE Global Research Center, 1 Research Circle, Niskayuna, 12309, New York, USA – sequence: 2 givenname: Andrei S. surname: Purysko fullname: Purysko, Andrei S. organization: Section of Abdominal Imaging and Nuclear Radiology Department, Imaging Institute, Cleveland Clinic – sequence: 3 givenname: Sadhna surname: Verma fullname: Verma, Sadhna organization: University of Cincinnati Medical Center – sequence: 4 givenname: Jonathan surname: Kiechle fullname: Kiechle, Jonathan organization: University Hospitals Cleveland Medical Center and Case Western Reserve University – sequence: 5 givenname: Jay surname: Gollamudi fullname: Gollamudi, Jay organization: University of Cincinnati Medical Center, Present Address: Department of Radiology, University Hospitals Cleveland Medical Center and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio, 44106, USA – sequence: 6 givenname: Soumya surname: Ghose fullname: Ghose, Soumya organization: Department of Biomedical Engineering, Case Western Reserve University – sequence: 7 givenname: Karin surname: Herrmann fullname: Herrmann, Karin organization: University Hospitals Cleveland Medical Center and Case Western Reserve University – sequence: 8 givenname: Vikas surname: Gulani fullname: Gulani, Vikas organization: University Hospitals Cleveland Medical Center and Case Western Reserve University – sequence: 9 givenname: Raj surname: Paspulati fullname: Paspulati, Raj organization: University Hospitals Cleveland Medical Center and Case Western Reserve University – sequence: 10 givenname: Lee surname: Ponsky fullname: Ponsky, Lee organization: University Hospitals Cleveland Medical Center and Case Western Reserve University – sequence: 11 givenname: Maret surname: Böhm fullname: Böhm, Maret organization: Garvan Institute of Medical Research, The Kinghorn Cancer Centre – sequence: 12 givenname: Anne-Maree surname: Haynes fullname: Haynes, Anne-Maree organization: Garvan Institute of Medical Research, The Kinghorn Cancer Centre – sequence: 13 givenname: Daniel surname: Moses fullname: Moses, Daniel organization: Radiology Department, Spectrum Medical Imaging – sequence: 14 givenname: Ron surname: Shnier fullname: Shnier, Ron organization: Southern Radiology, Neuroscience Research Australia – sequence: 15 givenname: Warick surname: Delprado fullname: Delprado, Warick organization: Douglass Hanly Moir Pathology – sequence: 16 givenname: James surname: Thompson fullname: Thompson, James organization: Garvan Institute of Medical Research, The Kinghorn Cancer Centre, St. Vincent’s Prostate Cancer Center, School of Medicine, University of New South Wales – sequence: 17 givenname: Phillip surname: Stricker fullname: Stricker, Phillip organization: St. Vincent’s Prostate Cancer Center – sequence: 18 givenname: Anant surname: Madabhushi fullname: Madabhushi, Anant email: anant.madabhushi@case.edu organization: Department of Biomedical Engineering, Case Western Reserve University
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Cites_doi	10.1097/00004728-199601000-00017 10.1016/S0022-5347(05)67711-7 10.1118/1.4881515 10.1002/jmri.24676 10.2307/3001968 10.1016/j.eururo.2015.08.052 10.1001/jama.1993.03510070082041 10.3174/ajnr.A0620 10.1002/hipo.20573 10.1007/s00330-011-2377-y 10.1016/j.media.2013.12.002 10.1002/(SICI)1097-0193(1998)6:5/6<348::AID-HBM4>3.0.CO;2-P 10.1109/MPUL.2011.942929 10.1148/radiol.11091822 10.1002/1097-0193(200008)10:4<204::AID-HBM60>3.0.CO;2-2 10.1016/j.neuroimage.2006.12.036 10.1002/jmri.24944 10.1371/annotation/c4d2aff9-0c5c-4ebb-b1ed-efa69fc84d78 10.1002/jmri.23618 10.1148/radiol.2392050949 10.1109/ISBI.2004.1398617 10.1109/NSSMIC.1993.373602
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Present Address: Department of Radiology, University Hospitals Cleveland Medical Center and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio, 44106, USA. Present Address: GE Global Research Center, 1 Research Circle, Niskayuna, 12309, New York, USA.
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Snippet	We seek to characterize differences in the shape of the prostate and the central gland (combined central and transitional zones) between men with biopsy...
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SubjectTerms	692/4025/1752 692/4028/67/589/466 Biopsy Chlorides Colorectal cancer Computer applications Dolphins & porpoises Humanities and Social Sciences Humans Hypertrophy Imaging, Three-Dimensional Institutions Magnetic Resonance Imaging Male Malignancy multidisciplinary Organ Size Pelvis Prostate - pathology Prostate cancer Prostatic Neoplasms - pathology Rectum Science Statistical analysis
Title	Computational imaging reveals shape differences between normal and malignant prostates on MRI
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