Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities

[Display omitted] Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting as delivery vehicles for molecular messages. During the last decade, EVs have been assigned multiple functions that have established their potential as therapeutic mediators for a variety...

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Vydané v:Advanced drug delivery reviews Ročník 175; s. 113775
Hlavní autori: Nagelkerke, Anika, Ojansivu, Miina, van der Koog, Luke, Whittaker, Thomas E., Cunnane, Eoghan M., Silva, Andreia M., Dekker, Niek, Stevens, Molly M.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Netherlands Elsevier B.V 01.08.2021
Predmet:
Animals
Clinical trial
Drug Delivery Systems - methods
EV engineering
EV-functionalized biomaterials
Extracellular Vesicles - physiology
Humans
Mesenchymal stem cells
Regenerative medicine
Regenerative Medicine - methods
Therapeutic cargo delivery
Tissue Engineering - methods
Therapeutic cargo delivery
Clinical trial
Regenerative medicine
EV engineering
EV-functionalized biomaterials
Mesenchymal stem cells
ISSN:0169-409X, 1872-8294, 1872-8294
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Abstract [Display omitted] Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting as delivery vehicles for molecular messages. During the last decade, EVs have been assigned multiple functions that have established their potential as therapeutic mediators for a variety of diseases and conditions. In this review paper, we report on the potential of EVs in tissue repair and regeneration. The regenerative properties that have been associated with EVs are explored, detailing the molecular cargo they carry that is capable of mediating such effects, the signaling cascades triggered in target cells and the functional outcome achieved. EV interactions and biodistribution in vivo that influence their regenerative effects are also described, particularly upon administration in combination with biomaterials. Finally, we review the progress that has been made for the successful implementation of EV regenerative therapies in a clinical setting.
AbstractList Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting as delivery vehicles for molecular messages. During the last decade, EVs have been assigned multiple functions that have established their potential as therapeutic mediators for a variety of diseases and conditions. In this review paper, we report on the potential of EVs in tissue repair and regeneration. The regenerative properties that have been associated with EVs are explored, detailing the molecular cargo they carry that is capable of mediating such effects, the signaling cascades triggered in target cells and the functional outcome achieved. EV interactions and biodistribution in vivo that influence their regenerative effects are also described, particularly upon administration in combination with biomaterials. Finally, we review the progress that has been made for the successful implementation of EV regenerative therapies in a clinical setting.Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting as delivery vehicles for molecular messages. During the last decade, EVs have been assigned multiple functions that have established their potential as therapeutic mediators for a variety of diseases and conditions. In this review paper, we report on the potential of EVs in tissue repair and regeneration. The regenerative properties that have been associated with EVs are explored, detailing the molecular cargo they carry that is capable of mediating such effects, the signaling cascades triggered in target cells and the functional outcome achieved. EV interactions and biodistribution in vivo that influence their regenerative effects are also described, particularly upon administration in combination with biomaterials. Finally, we review the progress that has been made for the successful implementation of EV regenerative therapies in a clinical setting.
[Display omitted] Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting as delivery vehicles for molecular messages. During the last decade, EVs have been assigned multiple functions that have established their potential as therapeutic mediators for a variety of diseases and conditions. In this review paper, we report on the potential of EVs in tissue repair and regeneration. The regenerative properties that have been associated with EVs are explored, detailing the molecular cargo they carry that is capable of mediating such effects, the signaling cascades triggered in target cells and the functional outcome achieved. EV interactions and biodistribution in vivo that influence their regenerative effects are also described, particularly upon administration in combination with biomaterials. Finally, we review the progress that has been made for the successful implementation of EV regenerative therapies in a clinical setting.
Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting as delivery vehicles for molecular messages. During the last decade, EVs have been assigned multiple functions that have established their potential as therapeutic mediators for a variety of diseases and conditions. In this review paper, we report on the potential of EVs in tissue repair and regeneration. The regenerative properties that have been associated with EVs are explored, detailing the molecular cargo they carry that is capable of mediating such effects, the signaling cascades triggered in target cells and the functional outcome achieved. EV interactions and biodistribution in vivo that influence their regenerative effects are also described, particularly upon administration in combination with biomaterials. Finally, we review the progress that has been made for the successful implementation of EV regenerative therapies in a clinical setting.
ArticleNumber 113775
Author van der Koog, Luke
Dekker, Niek
Cunnane, Eoghan M.
Silva, Andreia M.
Stevens, Molly M.
Nagelkerke, Anika
Ojansivu, Miina
Whittaker, Thomas E.
Author_xml – sequence: 1
  givenname: Anika
  orcidid: 0000-0002-7541-588X
  surname: Nagelkerke
  fullname: Nagelkerke, Anika
  email: a.p.nagelkerke@rug.nl
  organization: Pharmaceutical Analysis, Groningen Research Institute of Pharmacy, University of Groningen, P.O. Box 196, XB20, 9700 AD Groningen, the Netherlands
– sequence: 2
  givenname: Miina
  orcidid: 0000-0002-5493-3530
  surname: Ojansivu
  fullname: Ojansivu, Miina
  email: miina.ojansivu@ki.se
  organization: Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
– sequence: 3
  givenname: Luke
  surname: van der Koog
  fullname: van der Koog, Luke
  email: l.van.der.koog@rug.nl
  organization: Molecular Pharmacology, Groningen Research Institute of Pharmacy, University of Groningen, P.O. Box 196, XB10, 9700 AD Groningen, the Netherlands
– sequence: 4
  givenname: Thomas E.
  orcidid: 0000-0002-3181-4571
  surname: Whittaker
  fullname: Whittaker, Thomas E.
  organization: Department of Materials, Imperial College London, London, UK
– sequence: 5
  givenname: Eoghan M.
  orcidid: 0000-0001-5599-9040
  surname: Cunnane
  fullname: Cunnane, Eoghan M.
  email: e.cunnane@imperial.ac.uk
  organization: Department of Materials, Imperial College London, London, UK
– sequence: 6
  givenname: Andreia M.
  orcidid: 0000-0001-6365-1407
  surname: Silva
  fullname: Silva, Andreia M.
  email: andreia.silva@astrazeneca.com
  organization: Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
– sequence: 7
  givenname: Niek
  orcidid: 0000-0001-8245-6041
  surname: Dekker
  fullname: Dekker, Niek
  email: niek.dekker@astrazeneca.com
  organization: Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
– sequence: 8
  givenname: Molly M.
  surname: Stevens
  fullname: Stevens, Molly M.
  email: m.stevens@imperial.ac.uk
  organization: Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33872693$$D View this record in MEDLINE/PubMed
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Keywords Therapeutic cargo delivery
Clinical trial
Regenerative medicine
EV engineering
EV-functionalized biomaterials
Mesenchymal stem cells
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Snippet [Display omitted] Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting as delivery vehicles for molecular messages....
Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting as delivery vehicles for molecular messages. During the last...
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SubjectTerms Animals
Clinical trial
Drug Delivery Systems - methods
EV engineering
EV-functionalized biomaterials
Extracellular Vesicles - physiology
Humans
Mesenchymal stem cells
Regenerative medicine
Regenerative Medicine - methods
Therapeutic cargo delivery
Tissue Engineering - methods
Title Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities
URI https://dx.doi.org/10.1016/j.addr.2021.04.013
https://www.ncbi.nlm.nih.gov/pubmed/33872693
https://www.proquest.com/docview/2515685364
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