Tissue-specific iron levels modulate lipid peroxidation and the FLASH radiotherapy effect

Iron is vital to living cells, playing a key role in cellular respiration, DNA synthesis, and various metabolic functions. Importantly, cancer cells have a higher dependency on iron compared to normal cells to support their rapid growth and survival. Due to this fact, tumors are more vulnerable to f...

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Vydáno v:	Cell death & disease Ročník 16; číslo 1; s. 668 - 14
Hlavní autoři:	Vilaplana-Lopera, Nuria, Kim, Jiyoung, Nam, Gilyeong, Tullis, Iain D. C., Paillas, Salome, Ruan, Jia-Ling, Lee, Pei Ju, Jiang, Yanyan, Park, Sohee, Hou, Tianxu, Nasir, Ayesha, Charlesworth, Eve, Walker, Ellie, Abu-Halawa, Ammar, Hill, Mark A., Choi, Changhoon, Lee, Ik Jae, Jeong, Youngtae, Lakhal-Littleton, Samira, Then, Chee Kin, Shen, Shing-Chuan, Giaccia, Amato J., Petersson, Kristoffer, Moon, Eui Jung
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 02.09.2025 Springer Nature B.V Nature Publishing Group
Témata:	13/51 13/89 631/67/327 64/60 692/308/2778 96/106 Animals Antibiotics Antibodies Biochemistry Biomedical and Life Sciences Cancer therapies Cell Biology Cell Culture Cell death Cell Line, Tumor Diet DNA biosynthesis Dosimetry Experiments Ferroptosis Ferroptosis - radiation effects Humans Immunology Iron Iron - metabolism Life Sciences Lipid peroxidation Lipid Peroxidation - radiation effects Lipids Mice Mice, Inbred C57BL Neoplasms - metabolism Neoplasms - pathology Neoplasms - radiotherapy Organ Specificity Radiation therapy Radiotherapy - methods Tumor cells Tumors United Kingdom > UK Japan Germany
ISSN:	2041-4889, 2041-4889
On-line přístup:	Získat plný text
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