Proton MRS of cervical cancer at 7 T

The differentiation grade of cervical cancer is histologically assessed by examining biopsies or surgical specimens. MRS is a highly sensitive technique that images tissue metabolism and can be used to increase the specificity of tissue characterization in a non‐invasive manner. We aim to explore th...

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Veröffentlicht in:NMR in biomedicine Jg. 32; H. 1; S. e4015 - n/a
Hauptverfasser: Arteaga de Castro, C.S., Hoogendam, J.P., Kalleveen, I.M.L., Raaijmakers, A.J.E., Zweemer, R.P., Verheijen, R.H.M., Luijten, P.R., Veldhuis, W.B., Klomp, D.W.J.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Wiley Subscription Services, Inc 01.01.2019
John Wiley and Sons Inc
Schlagworte:
7 T
Adult
Aged
Biological products
Cancer
Cervical cancer
Cervix
Fatty acid composition
Fatty acids
Fatty Acids - metabolism
Feasibility
Feasibility studies
Female
FIGO stage
Human papillomavirus
Humans
Metabolism
Middle Aged
Monopole antennas
MRS
Neoplasm Grading
Proton Magnetic Resonance Spectroscopy
Ratios
Steam
Surgery
Tissues
tumor grade
Tumors
Uterine cancer
Uterine Cervical Neoplasms - diagnostic imaging
Uterine Cervical Neoplasms - pathology
Uterus
7 T
fatty acids
cervical cancer
FIGO stage
MRS
tumor grade
ISSN:0952-3480, 1099-1492, 1099-1492
Online-Zugang:Volltext
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Zusammenfassung:The differentiation grade of cervical cancer is histologically assessed by examining biopsies or surgical specimens. MRS is a highly sensitive technique that images tissue metabolism and can be used to increase the specificity of tissue characterization in a non‐invasive manner. We aim to explore the feasibility of using in vivo 1H‐MRS at 7 T in women with cervical cancer to study tissue fatty acid composition. 10 women with histologically proven Stage IB1‐IIB cervical cancer were scanned with a whole‐body 7 T MR system with a multi‐transmit system and an internal receive only monopole antenna. A STEAM sequence was used to obtain 1H‐MRS data. Fatty acid resonances were fitted with Lorentzian curves and the 2.1 ppm/1.3 ppm ratios were calculated. 1H‐MRS data showed fatty acid signals resonating at 2.1 ppm, 1.9 ppm, 1.5 ppm, 1.3 ppm and 0.9 ppm. Mean 2.1/1.3 ppm ratios were 0.019 ± 0.01, 0.021 ± 0.006, 0.12 ± 0.089 and 0.39 ± 0.27 for normal, Grade I, Grade II and Grade III groups respectively. Poorly differentiated tumor tissue (Grade III) showed elevated fatty acid ratios when compared with the well differentiated tumor (Grade I) or normal tissue. 1H‐MRS in cervical cancer at 7 T is feasible and individual fatty acid signals were detected. In addition, poorly differentiated tumors show more fatty acid unsaturation. The 2.1 ppm/1.3 ppm ratio has potential for tumor characterization in a non‐invasive manner for uterine cervical cancer. The feasibility of fatty acid characterization was investigated at ultra‐high field. Fatty acids in uterine cervix were measured in a single voxel with MRS at 7 T in 10 patients with cervical cancer and 5 healthy volunteers. Fatty acids were fitted and the 2.1 ppm/1.3 ppm ratios were calculated for each subject. These showed a trend towards unsaturation of the fatty acids in poorly differentiated tumors, when compared with well differentiated tumors or normal tissue.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0952-3480
1099-1492
1099-1492
DOI:10.1002/nbm.4015