Proton MRS of cervical cancer at 7 T
The differentiation grade of cervical cancer is histologically assessed by examining biopsies or surgical specimens. MRS is a highly sensitive technique that images tissue metabolism and can be used to increase the specificity of tissue characterization in a non‐invasive manner. We aim to explore th...
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| Published in: | NMR in biomedicine Vol. 32; no. 1; pp. e4015 - n/a |
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| Abstract | The differentiation grade of cervical cancer is histologically assessed by examining biopsies or surgical specimens.
MRS is a highly sensitive technique that images tissue metabolism and can be used to increase the specificity of tissue characterization in a non‐invasive manner. We aim to explore the feasibility of using in vivo 1H‐MRS at 7 T in women with cervical cancer to study tissue fatty acid composition.
10 women with histologically proven Stage IB1‐IIB cervical cancer were scanned with a whole‐body 7 T MR system with a multi‐transmit system and an internal receive only monopole antenna. A STEAM sequence was used to obtain 1H‐MRS data. Fatty acid resonances were fitted with Lorentzian curves and the 2.1 ppm/1.3 ppm ratios were calculated.
1H‐MRS data showed fatty acid signals resonating at 2.1 ppm, 1.9 ppm, 1.5 ppm, 1.3 ppm and 0.9 ppm. Mean 2.1/1.3 ppm ratios were 0.019 ± 0.01, 0.021 ± 0.006, 0.12 ± 0.089 and 0.39 ± 0.27 for normal, Grade I, Grade II and Grade III groups respectively. Poorly differentiated tumor tissue (Grade III) showed elevated fatty acid ratios when compared with the well differentiated tumor (Grade I) or normal tissue.
1H‐MRS in cervical cancer at 7 T is feasible and individual fatty acid signals were detected. In addition, poorly differentiated tumors show more fatty acid unsaturation. The 2.1 ppm/1.3 ppm ratio has potential for tumor characterization in a non‐invasive manner for uterine cervical cancer.
The feasibility of fatty acid characterization was investigated at ultra‐high field. Fatty acids in uterine cervix were measured in a single voxel with MRS at 7 T in 10 patients with cervical cancer and 5 healthy volunteers. Fatty acids were fitted and the 2.1 ppm/1.3 ppm ratios were calculated for each subject. These showed a trend towards unsaturation of the fatty acids in poorly differentiated tumors, when compared with well differentiated tumors or normal tissue. |
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| AbstractList | The differentiation grade of cervical cancer is histologically assessed by examining biopsies or surgical specimens.MRS is a highly sensitive technique that images tissue metabolism and can be used to increase the specificity of tissue characterization in a non‐invasive manner. We aim to explore the feasibility of using in vivo 1H‐MRS at 7 T in women with cervical cancer to study tissue fatty acid composition.10 women with histologically proven Stage IB1‐IIB cervical cancer were scanned with a whole‐body 7 T MR system with a multi‐transmit system and an internal receive only monopole antenna. A STEAM sequence was used to obtain 1H‐MRS data. Fatty acid resonances were fitted with Lorentzian curves and the 2.1 ppm/1.3 ppm ratios were calculated.1H‐MRS data showed fatty acid signals resonating at 2.1 ppm, 1.9 ppm, 1.5 ppm, 1.3 ppm and 0.9 ppm. Mean 2.1/1.3 ppm ratios were 0.019 ± 0.01, 0.021 ± 0.006, 0.12 ± 0.089 and 0.39 ± 0.27 for normal, Grade I, Grade II and Grade III groups respectively. Poorly differentiated tumor tissue (Grade III) showed elevated fatty acid ratios when compared with the well differentiated tumor (Grade I) or normal tissue.1H‐MRS in cervical cancer at 7 T is feasible and individual fatty acid signals were detected. In addition, poorly differentiated tumors show more fatty acid unsaturation. The 2.1 ppm/1.3 ppm ratio has potential for tumor characterization in a non‐invasive manner for uterine cervical cancer. The differentiation grade of cervical cancer is histologically assessed by examining biopsies or surgical specimens. MRS is a highly sensitive technique that images tissue metabolism and can be used to increase the specificity of tissue characterization in a non‐invasive manner. We aim to explore the feasibility of using in vivo 1H‐MRS at 7 T in women with cervical cancer to study tissue fatty acid composition. 10 women with histologically proven Stage IB1‐IIB cervical cancer were scanned with a whole‐body 7 T MR system with a multi‐transmit system and an internal receive only monopole antenna. A STEAM sequence was used to obtain 1H‐MRS data. Fatty acid resonances were fitted with Lorentzian curves and the 2.1 ppm/1.3 ppm ratios were calculated. 1H‐MRS data showed fatty acid signals resonating at 2.1 ppm, 1.9 ppm, 1.5 ppm, 1.3 ppm and 0.9 ppm. Mean 2.1/1.3 ppm ratios were 0.019 ± 0.01, 0.021 ± 0.006, 0.12 ± 0.089 and 0.39 ± 0.27 for normal, Grade I, Grade II and Grade III groups respectively. Poorly differentiated tumor tissue (Grade III) showed elevated fatty acid ratios when compared with the well differentiated tumor (Grade I) or normal tissue. 1H‐MRS in cervical cancer at 7 T is feasible and individual fatty acid signals were detected. In addition, poorly differentiated tumors show more fatty acid unsaturation. The 2.1 ppm/1.3 ppm ratio has potential for tumor characterization in a non‐invasive manner for uterine cervical cancer. The differentiation grade of cervical cancer is histologically assessed by examining biopsies or surgical specimens. MRS is a highly sensitive technique that images tissue metabolism and can be used to increase the specificity of tissue characterization in a non-invasive manner. We aim to explore the feasibility of using in vivo 1 H-MRS at 7 T in women with cervical cancer to study tissue fatty acid composition. 10 women with histologically proven Stage IB1-IIB cervical cancer were scanned with a whole-body 7 T MR system with a multi-transmit system and an internal receive only monopole antenna. A STEAM sequence was used to obtain 1 H-MRS data. Fatty acid resonances were fitted with Lorentzian curves and the 2.1 ppm/1.3 ppm ratios were calculated. 1 H-MRS data showed fatty acid signals resonating at 2.1 ppm, 1.9 ppm, 1.5 ppm, 1.3 ppm and 0.9 ppm. Mean 2.1/1.3 ppm ratios were 0.019 ± 0.01, 0.021 ± 0.006, 0.12 ± 0.089 and 0.39 ± 0.27 for normal, Grade I, Grade II and Grade III groups respectively. Poorly differentiated tumor tissue (Grade III) showed elevated fatty acid ratios when compared with the well differentiated tumor (Grade I) or normal tissue. 1 H-MRS in cervical cancer at 7 T is feasible and individual fatty acid signals were detected. In addition, poorly differentiated tumors show more fatty acid unsaturation. The 2.1 ppm/1.3 ppm ratio has potential for tumor characterization in a non-invasive manner for uterine cervical cancer.The differentiation grade of cervical cancer is histologically assessed by examining biopsies or surgical specimens. MRS is a highly sensitive technique that images tissue metabolism and can be used to increase the specificity of tissue characterization in a non-invasive manner. We aim to explore the feasibility of using in vivo 1 H-MRS at 7 T in women with cervical cancer to study tissue fatty acid composition. 10 women with histologically proven Stage IB1-IIB cervical cancer were scanned with a whole-body 7 T MR system with a multi-transmit system and an internal receive only monopole antenna. A STEAM sequence was used to obtain 1 H-MRS data. Fatty acid resonances were fitted with Lorentzian curves and the 2.1 ppm/1.3 ppm ratios were calculated. 1 H-MRS data showed fatty acid signals resonating at 2.1 ppm, 1.9 ppm, 1.5 ppm, 1.3 ppm and 0.9 ppm. Mean 2.1/1.3 ppm ratios were 0.019 ± 0.01, 0.021 ± 0.006, 0.12 ± 0.089 and 0.39 ± 0.27 for normal, Grade I, Grade II and Grade III groups respectively. Poorly differentiated tumor tissue (Grade III) showed elevated fatty acid ratios when compared with the well differentiated tumor (Grade I) or normal tissue. 1 H-MRS in cervical cancer at 7 T is feasible and individual fatty acid signals were detected. In addition, poorly differentiated tumors show more fatty acid unsaturation. The 2.1 ppm/1.3 ppm ratio has potential for tumor characterization in a non-invasive manner for uterine cervical cancer. The differentiation grade of cervical cancer is histologically assessed by examining biopsies or surgical specimens. MRS is a highly sensitive technique that images tissue metabolism and can be used to increase the specificity of tissue characterization in a non‐invasive manner. We aim to explore the feasibility of using in vivo 1H‐MRS at 7 T in women with cervical cancer to study tissue fatty acid composition. 10 women with histologically proven Stage IB1‐IIB cervical cancer were scanned with a whole‐body 7 T MR system with a multi‐transmit system and an internal receive only monopole antenna. A STEAM sequence was used to obtain 1H‐MRS data. Fatty acid resonances were fitted with Lorentzian curves and the 2.1 ppm/1.3 ppm ratios were calculated. 1H‐MRS data showed fatty acid signals resonating at 2.1 ppm, 1.9 ppm, 1.5 ppm, 1.3 ppm and 0.9 ppm. Mean 2.1/1.3 ppm ratios were 0.019 ± 0.01, 0.021 ± 0.006, 0.12 ± 0.089 and 0.39 ± 0.27 for normal, Grade I, Grade II and Grade III groups respectively. Poorly differentiated tumor tissue (Grade III) showed elevated fatty acid ratios when compared with the well differentiated tumor (Grade I) or normal tissue. 1H‐MRS in cervical cancer at 7 T is feasible and individual fatty acid signals were detected. In addition, poorly differentiated tumors show more fatty acid unsaturation. The 2.1 ppm/1.3 ppm ratio has potential for tumor characterization in a non‐invasive manner for uterine cervical cancer. The feasibility of fatty acid characterization was investigated at ultra‐high field. Fatty acids in uterine cervix were measured in a single voxel with MRS at 7 T in 10 patients with cervical cancer and 5 healthy volunteers. Fatty acids were fitted and the 2.1 ppm/1.3 ppm ratios were calculated for each subject. These showed a trend towards unsaturation of the fatty acids in poorly differentiated tumors, when compared with well differentiated tumors or normal tissue. The differentiation grade of cervical cancer is histologically assessed by examining biopsies or surgical specimens. MRS is a highly sensitive technique that images tissue metabolism and can be used to increase the specificity of tissue characterization in a non-invasive manner. We aim to explore the feasibility of using in vivo H-MRS at 7 T in women with cervical cancer to study tissue fatty acid composition. 10 women with histologically proven Stage IB1-IIB cervical cancer were scanned with a whole-body 7 T MR system with a multi-transmit system and an internal receive only monopole antenna. A STEAM sequence was used to obtain H-MRS data. Fatty acid resonances were fitted with Lorentzian curves and the 2.1 ppm/1.3 ppm ratios were calculated. H-MRS data showed fatty acid signals resonating at 2.1 ppm, 1.9 ppm, 1.5 ppm, 1.3 ppm and 0.9 ppm. Mean 2.1/1.3 ppm ratios were 0.019 ± 0.01, 0.021 ± 0.006, 0.12 ± 0.089 and 0.39 ± 0.27 for normal, Grade I, Grade II and Grade III groups respectively. Poorly differentiated tumor tissue (Grade III) showed elevated fatty acid ratios when compared with the well differentiated tumor (Grade I) or normal tissue. H-MRS in cervical cancer at 7 T is feasible and individual fatty acid signals were detected. In addition, poorly differentiated tumors show more fatty acid unsaturation. The 2.1 ppm/1.3 ppm ratio has potential for tumor characterization in a non-invasive manner for uterine cervical cancer. |
| Author | Kalleveen, I.M.L. Verheijen, R.H.M. Luijten, P.R. Klomp, D.W.J. Veldhuis, W.B. Raaijmakers, A.J.E. Arteaga de Castro, C.S. Zweemer, R.P. Hoogendam, J.P. |
| AuthorAffiliation | 1 Department of Radiology UMC Utrecht The Netherlands 2 Department of Gynecological Oncology UMC Utrecht Cancer Center The Netherlands 3 Department of Radiology the Netherlands Cancer Institute Amsterdam The Netherlands |
| AuthorAffiliation_xml | – name: 2 Department of Gynecological Oncology UMC Utrecht Cancer Center The Netherlands – name: 1 Department of Radiology UMC Utrecht The Netherlands – name: 3 Department of Radiology the Netherlands Cancer Institute Amsterdam The Netherlands |
| Author_xml | – sequence: 1 givenname: C.S. orcidid: 0000-0002-1055-2672 surname: Arteaga de Castro fullname: Arteaga de Castro, C.S. email: c.s.arteagadecastro@umcutrecht.nl organization: UMC Utrecht – sequence: 2 givenname: J.P. surname: Hoogendam fullname: Hoogendam, J.P. organization: UMC Utrecht Cancer Center – sequence: 3 givenname: I.M.L. orcidid: 0000-0001-8916-4279 surname: Kalleveen fullname: Kalleveen, I.M.L. organization: the Netherlands Cancer Institute – sequence: 4 givenname: A.J.E. surname: Raaijmakers fullname: Raaijmakers, A.J.E. organization: UMC Utrecht – sequence: 5 givenname: R.P. surname: Zweemer fullname: Zweemer, R.P. organization: UMC Utrecht Cancer Center – sequence: 6 givenname: R.H.M. surname: Verheijen fullname: Verheijen, R.H.M. organization: UMC Utrecht Cancer Center – sequence: 7 givenname: P.R. surname: Luijten fullname: Luijten, P.R. organization: UMC Utrecht – sequence: 8 givenname: W.B. surname: Veldhuis fullname: Veldhuis, W.B. organization: UMC Utrecht – sequence: 9 givenname: D.W.J. surname: Klomp fullname: Klomp, D.W.J. organization: UMC Utrecht |
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| Cites_doi | 10.1097/00004424-199401000-00003 10.1002/mrm.25596 10.1097/00128360-200204000-00004 10.1002/(SICI)1522-2594(199904)41:4<649::AID-MRM2>3.0.CO;2-G 10.1097/01.AOG.0000132803.88049.84 10.2214/ajr.170.5.9574601 10.1002/nbm.1723 10.1006/jmre.1998.1458 10.1148/radiol.2491072165 10.1038/sj.pcan.4500879 10.2214/ajr.166.3.8623627 10.1111/liv.13451 10.1038/nrc3483 10.1002/jmri.20012 10.1007/s00330-003-1928-2 10.1007/s00330-015-3899-5 10.1194/jlr.D800010-JLR200 10.1002/mrm.24131 10.1097/RLI.0000000000000183 10.1016/j.juro.2009.06.015 10.1148/radiology.188.3.8351349 10.1002/nbm.830 10.1016/j.cmet.2013.05.017 10.1148/radiology.172.2.2748837 10.1002/nbm.3750 10.1002/cncr.22945 10.1111/j.1471-0528.1997.tb10658.x 10.1002/nbm.869 10.1309/AJCP6BSD0SNGQLHQ 10.1007/s00330-016-4419-y 10.1097/01.rli.0000251541.03822.bb 10.1002/mrm.21476 10.1148/radiol.2223010558 10.1148/radiology.193.3.7972810 10.1002/jcb.10708 10.1097/00000421-200110000-00021 10.1002/mrm.23200 10.1002/mrm.21335 10.1148/radiology.178.3.1994421 10.1002/jmri.22623 10.1002/hep.22220 |
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| Keywords | 7 T fatty acids cervical cancer FIGO stage MRS tumor grade |
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MRS is a highly sensitive technique that... The differentiation grade of cervical cancer is histologically assessed by examining biopsies or surgical specimens. MRS is a highly sensitive technique that... The differentiation grade of cervical cancer is histologically assessed by examining biopsies or surgical specimens.MRS is a highly sensitive technique that... |
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| SubjectTerms | 7 T Adult Aged Biological products Cancer Cervical cancer Cervix Fatty acid composition Fatty acids Fatty Acids - metabolism Feasibility Feasibility studies Female FIGO stage Human papillomavirus Humans Metabolism Middle Aged Monopole antennas MRS Neoplasm Grading Proton Magnetic Resonance Spectroscopy Ratios Steam Surgery Tissues tumor grade Tumors Uterine cancer Uterine Cervical Neoplasms - diagnostic imaging Uterine Cervical Neoplasms - pathology Uterus |
| Title | Proton MRS of cervical cancer at 7 T |
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